宫颈癌的筛查方法及其评价

()()()443002R737133A100124411(2008)2022900203,,1,13115,1/4210,5,,3,:1111(ConventionalPapanicolaouTest,CPT)CPT,,,,,,Pap,4,CPT(),,5Meta6,97%100%,29%56%,,,,,,,,,,112(Liquid-basedCytologyTest,LCT)TCT(thin-prepcytologytest)AutoCytePrep,()5,ThinPrep,,ThinPrep,,95%,,TBS,,,LCT,,,,,,,,,79312%(HSIL)100%LCT,,HPV,8,,,/(ASCUS/AGUS)LCT,,113(ComputerassistantCellTest,CCT)(CCT),,CCT,,,,,TBS9,,PAPNETAUTOPAPCCT,,,,,2211(VisualInspection),3%5%,,10,199911,7019%7413%,9813%,1116%,,,,,,,212(Colposcopy)0092200823,()2090,,,,,199911,8114%,7615%,CIN9017%,,,12%15%,1210004,,4,114(%)TCT8812931891186157213711771191717801174147519121961198219751420131,TCT3HPV-DNA(HPV)8HPV100,HPVHPV16183133353945515256585968;HPV611424344HPV13,13HPV1495%HPV-DNA15HPV,,,,,HPV,Cuz2ik16,HPV,HPV,HPVHPV,HPV,,HPV(CIN)(85%9816%),(99%100%),40%85%17234022CINCIN(%)HPV-DNA9113374151512199179ASCUS90180801451213099150LSIL69198901601110999149HSIL491019816429120991311862433(%)HPV-DNA90158111851636119912TCT87129015911541169615791158115811161998125311621363151812961442166712711417159914,HPV(HC)(PCR)SouthenPCR;;,(FDA)(hybridcaptureHC-)HC-DigeneHPV-DNA,,HPV-DNA,HPV,13,,1910,HC-CIN9512%,8519%12,HPV(HCPCR)CINCIN25%30%,8%10%,HC,109220,HPV20HPV-DNA21,,,4h,96,90,,,,,-22,HPV-DNA41,,etal11(),2006,3(2):2432,11,2005,16(6):4043,11,2004,28(6):3494HenryC,PhilipE,ThomasJ1Achievementsandlimitationsofcervicalcytologyscreening1Vaccine,2006,24(3):635BrendaE,WoloshinS1Screeningforcervicalcancer:Willwomenac2ceptless?TheAmericanJournalofMedicine,2005,(118):1516FerenezyA,FrancoE1Cervical-cancerscreeningbeyondtheyear20001LancetOncology,2001,2(1):277,,etal11,2001,23(4):3098MichaelJ,MatthewJ,SinghMetal1IRmicrospectroscopy:potentialapplicationsincervicalcancerscreening1CancerLetters,2007,246:19,,11,2004,19:7110,,etal11,2002,24(1):5011,,etal11,2003,22(10):109612,,etal11,2005,26(24):1613GMClifford,SGallus,RHerreroetal1Worldwidedistributionofhu2manpapillomavirustypesincytologicallynormalwomenintheInterna2tionalAgencyforResearchonCancerHPVprevalencesurveys:apooledanalysis1Lancet,2005,366:99114MaxwellD,BrayF1TheburdenofHPV-relatedcancers1Vaccine,2006,24(3):1115ThomasC1HPVDNATestingforCervicalCancerScreening1Interna2tionalffournalofGynocology&Obstetrics,2006,95(1):23916CoxT,CuzickJ1HPVDNAtestingincervicalcancerscreening:Fromevidencetopolicies1GynecologicOncology,2006,103(1):817,1DNA1,2006,21(24):343418,,etal11,2006,35(7):84219,,etal11,2005,85(2):12920KateS,HeatherA1Theroleofhumanpapillomavirustestingincervi2calscreening1JournalofClinicalVirology,2005,32:3421CriccaM,BonviciniF,VenturoliSetal1Efficienttreatmentofparaffin-embeddedcervicaltissueforHPVDNAtestingbyHC-IIandPCRassays1JournalofClinicalVirology,2004,29(2):1372211,2005,12(6):1061(2007204205)100026R73713B100124411(2008)20229022051972Kerr1,2(apoptosis)(programmedcelldeath,PCD),,,,,1,3111(apoptosison)11111p53p53,17131(17P1311),20kb,1110,p53,:,2092200823