多发性硬化患者正电子发射体层成像显像与认知功能障碍的关系

,,,,,(PET)(MS)2MSMRIPET,1(MMSE)19,;2PET2;MRIMS,;;R744.5A100421648(2008)0320216203RelationshipbetweenpositronemissiontomographyandcognitivedsyfunctioninpatientswithmultiplesclerosisCHENLi2ping,WUWei2ping,MAOYan2ling,etal.DepartmentofNeurology,theSecondHospitalofHebeiMedicalUniversity,Shijiazhuang050051,ChinaAbstract:ObjectiveToinvestigatetherelationshipbetweenpositronemissiontomography(PET)andcognitivedsyfunctioninpatientswithmultiplesclerosis(MS).Methods2casesofMSweretestwiththeWechslerIntelligenceScale(WIS)ormini2mentalstateexamination(MMSE),brainMRIandPET,thentheresultswereanalysed.ResultsTheMMSEscoreofthecase1was19,whichwaslowerthannormal.TheWISscoreofthecase2wasnormal.ThePETof2patientsshowedthatthereweremanyhypo2metablismareasincortexorsubcortex.Inaddition,somecorticalhypo2metablismareasofPETwerenotcorrespondinglyfoundlesionsincortexorsubcortexbyMRI.ConclusionsTherearemanyhypo2metablismareasincortexorsubcortexinMSpatients.ThehypometablismareasmaybecorrelatedwiththecognitivedysfunctionofMS.Keywords:multiplesclerosis;cognitivefunction;PET:(01Z041):050051,();(,),(,);()(MS),40%72%MS(PET)MRI2(MS)11.1MS21:,35,8,22005138,;20046MRIT1T2;11MRI,T1T2;,MS:,,,;,-,,(+):MS2:,16,13d2005711,,:,,,,(+),-,,,(+)MRIT1T2,;:MS1.21.2.1(EDSS),010,1.2.2612JClinNeurol,June2008,Vol.21,No.3(VIQ)(PIQ)(FIQ);FIQ90(2)(MMSE),1720241.2.3PETPETSIE2MENSECATEXACTHR+,18(18F2FDG),(SPM)[1],SPM(ROI)22.1EDSS14.0,23.02(),12.21,MMSE19,2VIQ:109;PIQ:101;FIQ:106,2.3PET1PET,,SPMMRIT1,MRI(15)2PET,,MRISPM,(68)SPMTalairch,1;2121:MRIT1T2,T1T2341:PET,,51:PETSPMMRT1(,)62:MRIT272:PETSPMMRT1(,)82:P0101SPMPET,3[2,3]40%65%MS,10%MSMS,,,[4],12IQ,,,2PET,,,[5,6]PETMS,MS[6][527]MS,2(1):27122008213,,(),(2):,MRI2SPM,,Sun[6]MS,,MRI,PET,PET[5,6](3):MS,[8]2EDSS,2EDSS,[2,9][9],EDSS3,PET1MRI,,PETPET,PET,MS,PETMRI,MS[][1],,.SPM[J].,2005,13:223.[2]KarlinskaI,SelmajK.Cognitiveimpairmentinmultiplesclerosis[J].NeurolNeurochirPol,2005,39:125.[3],,,.MRI[J].,2004,17:327.[4].(7)[M].:..:,2001.40.[5]SorensenPS,JonssonA,MathiesenHK,etal.Therelationshipbe2tweenMRIandPETchangesandcognitivedisturbancesinMS[J].JNeurolSci,2006,245:99.[6]SunX,TanakaM,KondoS,etal.Clinicalsignificanceofreducedcerebralmetabolisminmultiplesclerosis:AcombinedPETandMRIstudy[J].AnnNuclMed,1998,12:89.[7]KutzelniggA,LucchinettiCF,LassmannH,etal.Corticaldemyeli2nationanddiffusewhitematterinjuryinmultiplesclerosis[J].Brain,2005,128:2705.[8]PetersonJW,BoL,MorkS,etal.Transectedneuritis,apoptoticneu2ronsandreducedinflammationneuincorticalmultiplesclerosisle2sions[J].AnnNeuron,2001,50:389.[9]EllgerT,BethkeF,FreseA,etal.Event2relatedpotentialsindiffer2entsubtypesofmultiplesclerosisacross2sectionalstudy[J].JNeu2rolSci,2002,205:35.(20072092112007212217)()(CA)/(EM)(VINITI)(IC)(CSA)()2005,50%,1,57,,2008;;//;;//;6,3,,::[e-mail];:024223389106024223384352;:024223388105;:[e-mail],[e-mail];:82584;:1200;:110004;:12/;www.zglckf.com812JClinNeurol,June2008,Vol.21,No.3