肿瘤病人的代谢特点_王革非

:1005-2205(2002)11-0690-03王革非　　任建安　黎介寿　:(,210002):R6　　:A　　,。,,。。1　(energyexpenditure,EE)。,(BEE)(REE)。Harris-Benedict,90%～110%,110%,90%。,6%～100%[2]。。Bozetti[2],60%,20%,,。Lukerich[3],6823(33.8%),,。denBroede[4],3013(44%),1312。,,,。Dempsey[5]Knox[6]58%59%,。Knox,12.8,21.0,32.8。、、、[6],Dempsey[5],,;;。Zylicz[7],,;,;,。,、、。,。:、;,。2　:,、、,,Cori,,。,,,。Cori,2ATP,16ATP,18ATP,36ATP,、ATP。Brennan[8],,15,,,,Cori,。,,Herber44,70%40%,·690·2002112211,,。,,,,、。:。,,,42%。:、2～3;;。,,,,,。Cori,,。3　,,,,。(TG),TG(GL)(FFA),。、TG,,、,。、,,,。,、,,,32%,,,。Korber[9],,,(92%),42%,。(LCT),(MCT)(MCT/LCT)。(LPL),(CM)(VLDL)ApoC,TGFFAGL,CMTGVLDLTG。LPLTG,CM、VLDL。LPL,,,LPL,,LPL。LPL,。Younes[10]FFA、TG、VLDL,VLDL-TG,。7。、、、、,C75,。4　,,。,,,。15N-,32%35%,35%54%,。Shaw[11][2.24vs1.46vs1.34mg/(kg·min)],。。,1%～6%,,,,。、、、、、、、、、,,、、、。、,,,[12]。[13]、,。·691·2002112211[14]3H-/3H-,,。,、,、[15]。,,。:,,,,、、;、1,,,;S-,DNA、RNA、,;、3,,,AA,,,。,,。。—。,,“”,。,,。,,。,。,,S-,DNA、RNA、,。,,,。,,,G0、G1,S,[16]。L-。,,,。1　GundersonAH.Thebasalmetabolisminmyelogenousleukemiaanditsrelationtothebloodfindings.BostonMedSurgJ,1921,185(8):7852　BozettiF,PagnoniAM,delVecchioM.Excessivecaloricexpendi-tureasacauseofmalnutritioninpatientswithcancer.SurgGy-necolObstet,1980,150(3):2293　LukerichJD,MullenJ,FeurerID,etal.Ablationofabnormalen-ergyexpenditurebycurativetumorresection.ArchSurg,1990,125(3):3374　denBroederE,OeseburgB,LippensRJ,etal.Basalmetabolicrateinchildrenwithasolidtumour.EurJClinNutr,2001,55(8):6735　DempseyDT,FeurerID,KnoxLS,etal.Energyexpenditureinmalnourishedgastrointestinalcancerpatients.Cancer,1984,53(6):12656　KnoxLS,CrosbyLO,FeurerID,etal.Energyexpenditureinmalnourishedcancerpatients.AnnSurg,1983,197(2):1527　ZyliczZ,SchwantjeO,WagenerDJetal.Metabolicresponsetoenteralfoodindifferentphasesofcancercachexiainrats.Oncolo-gy,1990,47(1):878　BrennanMF,EkmanL.Metabolicconsequencesofnutritionalsupportofthecancerpatient.Cancer,1984,54(11Suppl):26279　KorberJ,PriceliusS,HeidrichM,etal.Increasedlipidutilizationinweightlosingandweightstablecancerpatientswithnormalbodyweight.EurJClinNutr,1999,53(9):74010　YounesRN,VydelingumNA,NoguchiY,etal(1990).Lipidkineticalterationsintumor-bearingrats:reversalbytumorexci-sion.JSurgRes,1990,48(4):32411　ShawJH,WolfeRR.Whole-bodyproteinkineticsinpatientswithearlyandadvancedgastrointestinalcancer:theresponsetoglucoseinfusionandtotalparenteralnutrition.Surgery,1988,103(2):14812　,,,..,2001,8(1):113　,,..,2000,7(1):4114　,,.3H-/3H-.,2002,10(1):3615　WangF,PermertJ.Specificaminoacidprofileinculturemediaconditionedbyhumanpancreaticcancercelllines.Pancreatology,2002,2(4):40216　,,,..,2001,8(2):76(2002-08-10)·692·2002112211