口腔生态环境中的纳米菌与口腔疾病间的关系

36220093InternationalJournalofStomatologyVol.36No.2Mar.2009[]2008-04-10[]2008-09-27[]0640105[]1983-[]Tel[phone]nanotech-nologynanobacteriaNB。NB、、。1NB20～200nm0.1～0.4μm[1-2]。NB。NBpH7.4、。NBEubacteria[3]。NB。NB1。、NB。NB3～6d1[3]。NBα216SrRNA[4]。22.1NB。[5]。NB0.22μm50%15000r/min45min0.45μm50%15000r/min45min0.22μmNB。NB0.22μm（530021）[]100%。。、、、。。[][]Q939.1[]ATherelationshipbetweenthenanobacteriaintheoralecotopeandoraldiseaseHUANGXiao-qing,CHENWen-xia.Dept.ofOralMedicine,CollegeofStomatology,GuangxiMedicalUniversity,Nanning530021,China[Abstract]Nanobacteria,muchsmallerthanothercommonbacteria,cancreateanadamantshell.Itparticipatestheformationofthecalculusandisrelevanttomanykindsofdisease.Withitsbionomicsrevealedconsecutively,nanobacteriahasbecomeahotspotofresearch.Intheecologicalenvironmentoftheoralcavity,Thereisagreatdealofnanobacteriaeverywhere,suchasinsaliva,onthesurfaceoftheteeth,indentalplaque,incalculusden－talis,inpulpstoneandsoon.Thistextiswrittenafterreviewingagreatquantityofliterature.Therelationshipbetweenthenanobacteriaandotherdiseasewasraviewed.[Keywords]nanobacteriabionomicsoraldisease174··36220093InternationalJournalofStomatologyVol.36No.2Mar.2009164037℃5%～10%3～4、NB。2.2NB3[6]1DahlMcGec-RusselNB23NB。NBNanobacTEST-SNBNanobacTEST-U/A[7-9]。NanobacTEST-SNBNB。NBKajander[410]、、、NB。3NB。NB、、[10]。NB3T6、。4NBNB。4.1NBNB。NB、、。Kajander[10]30NB。Ciftcioglu[11]72NB70NB97.2%NB。Khullar[12]NBNBNB。NB。NBNB。Ciftcioglu[11]NB。NB、、。4.22002Shiekh[13]NBNB。Wood[14]100%NBNB60%NB。。[15]。Hung[16]NB。4.3NBNB。Hudelist[17]NBvonKossa。NB。[18]NBNB。NB。[19]NBNB。、175··36220093InternationalJournalofStomatologyVol.36No.2Mar.20092007,34158-65.[12]BurgemeisterS,DeckerEM,WeigerR,etal.EurJO－ralSci,2001,1096425-427.[13]SteinbergD,MoreinosD,FeatherstoneJ,etal.Antimi－crobAgentsChemother,2008,5272626-2631.[14]Maira-Litr觃nT,AllisonDG,GilbertP.JApplMicrobi－ol,2000,882243-247.[15]PasterBJ,BochesSK,GalvinJL,etal.JBacteriol,2001,183123770-3783.[16]ShemeshM,TamA,SteinbergD.Microbiology,2007,153Pt51307-1317.[17]ShemeshM,TamA,SteinbergD.JMedMicrobiol,2007,6Pt111528-1535.[18]BlackC,AllanI,FordSK,etal.ArchOralBiol,2004,494295-304.[19]LiYH,TangN,AspirasMB,etal.JBacteriol,2002,184102699-2708.[20]LiYH,HannaMN,Svens覿terG,etal.JBacteriol,2001,183236875-6884.[21]ChenX,SchauderS,PotierN,etal.Nature,2002,4156871545-549.[22]Welin-NeilandsJ,Svens覿terG.ApplEnvironMicrobiol,2007,73175633-5638.[23]ZhuM,TakenakaS,SatoM,etal.OralMicrobiolIm－munol,2001,16124-27.173!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!。NBNBNB。5NB、。。NB。NB[7]。NB、。6[1]CiftciogluN,McKayDS,MathewG,etal.JInvestigMed,2006,547385-394.[2],,,.,2006,418498-501.[3]KajanderEO.LettApplMicrobiol,2006,426549-552.[4]KajanderEO,CiftciogluN.ProcNatlAcadSciUSA,1998,95148274-8279.[5]KajanderEO,CiftciogluN,AhoK,etal.UrolRes,2003,31247-54.[6]HjelleJT,Miller-HjelleMA,PoxtonIR,etal.KidneyInt,2000,5762360-2374.[7]CiftciogluN,Miller-HjelleMA,HjelleJT,eta1.An-timicrobAgentsChemother,2002,4672077-2086.[8]KramerG,KlinglerHC,SteinerGE.CurrOpinUrol,2000,10135-38.[9]DrancourtM,JacomoV,LepidiH,etal.JClinMicro-biol,2003,411368-372.[10]KajanderEO,CiftciogluN,Miler-HjelleMA,etal.CurrOpinNephrolHypertens,2001,103445-452.[11]CiftciogluNM,BjorklundK,KuorikoskiK,etal.KidneyInt,1999,565l893-1898.[12]KhullarM,SharmaSK,SinghSK,etal.UrolRes,2004,323190-195.[13]ShiekhFA,KhullarM,SinghSK.UrolRes,2006,34153-57.[14]WoodHM,ShoskesDA.WorldJUrol,2006,24151-54.[15],.,2004,25844-45.[16]HungHC,WillettW,MerchantA,etal.Circulation,2003,10781152-1157.[17]HudelistG,SingerCF,KubistaE,etal.Histopathology,2004,456633-637.[18],,,.,2002,193214-215.[19],,,.,2006,123193-196.176··