临床酶学展望与标准化

:1007302050,,()(Warburg),(AMY)(LPS)(ALP)(ACP)2050(340nm)()(LD)AMI,,(ALT)(AST)(CK)(AMI)206070,()LDCK2MBAMI2(GGT)208090,(isoformisotype)CK2MB2/CK2MB1AMI/(mass)CK2MBmRNA,,,21,,,,1/41/3,,,,(v),(v=p/t2s/t),,,2070,ALT,40U,200UALP,3,13U,,mg,,,(p/t),(2s/t),,(mol):hmins,30min15min5min1min,60,:1mol1U,(IU),,IUI,UU/L70SI,SIKatal,IFCCKatak,KatalUU/L,mol,minL2070,IFCCMoss,()()()30,30,30,2919(ALTASTLDCKALPGGTAMY)30,6272003122612ChinJLabMed,December2003,Vol26,No.12©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.25,30,,37,,,,,3:,AMY,3457;LD,;pH,,ALPALP,IFCCALP90,30371999IFCC,37,6,IFCC,2002::IFCC30,37:15:IFCCIRMMBCR,IFCC,,,,2637:IFCC[ATP:N2(CK),EC2.71312]:IFCC[L2:NAD+(LD),EC11111127]:IFCCALT[L2:22ALT,EC2161112]:IFCCAST(L2:22AST,EC2161111):IFCC2[(2)2:GGT,EC2131212],,30IFCC,,,IFCC,(adenosinedeaminase,ADA)(paraoxonase,PON1)11ADA:()+()+,DNAADAADA:,,362,40638ADA32kb1220q122q13111;ADA,ADA,ADA(severecombinedimmunodeficiency,SCID)TB2RBCADA,(500/mm)ADA,TB2,,RBCADA3070RBCRBCADA::7272003122612ChinJLabMed,December2003,Vol26,No.12©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.:4:018113Ug/LHb:ADA1998,ADA():::,-20:::47U/L:50U/L:32U/LCSF:6U/LADA::253/254ADA47U/L:,50U/L,100%83%ADA:Voigt32U/L,95%100%,98%96%CSF:6U/L(9019%,94%)ADA2ADA:ADA,ADA,50ADA,,ADA15%40%,ADA,ADAADA:,ALTAST,ADAADA(9417%2212%),ADAADAALT,,,ADAALT,ALTADA,ADAALT,,ADAALT:ADA,90ADA2.(Paraoxonase,PON),PON,(aryldialkylphosphatase),EC3111811PON123PON1,,PON1PON,,,PON1HDLLDLPON1:CampsFerre(68107)368:(1)PON1(2)(52%,67%)(3),(4)ROC,PON1(AUC)ALTAUC,(TPALBBilALTGGTALP),PON1AUCPON1:(1),(2)IFCC(ALTASTCKLDGGTALPAMYCHELPS),(:2003209228)(:)8272003122612ChinJLabMed,December2003,Vol26,No.12©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.