神经病理性疼痛与细胞因子IL、TNF2α、

ILTNF2NGF:(2008J0091):350005,(),()(neuropathicpain)[1]()(),,,(interleukin,IL)(interferon,IFN),(colonystimulationfactor,CSF)(tumornecrosisfactor,TNF)(nervegrowth2factor,NGF)(transforminggrowthfactor,TGF),,21(IL21)26(IL26)28(IL28)TNF;24(IL24)210(IL210)22(sIL22R)(TNF2BP),,,,(polymorphonuclearleukocytes,PMNL),()()(52)()/()Na+AC(),()()()(),,AC,(EAAs)P(SP),(PTNs)AMPANK1,,,,,,NMDA,Ca2+,NO;NO,EAAsSP,,[2],,SPATPEAAsNOPGs,,(ROSNOPGsEAAsATPNGF)(IL21IL26TNF),,EAAsSP(TNF2)21(IL21)IL26,,,,,,,,,,[3]ILTNF2NGFRittner[4],,,,(IL21IL26TNF2),()IL2l,,[IL24IL210IL21(IL2Ira)],,(),IL26IL21TNF236320094254JClinAnesthesiol,April2009,Vol.25,No.4,IL21ra,IL21IL21IL21,/,,,IL21Deleo[5]IL21Okamoto[6]RT2PCRIL21mRNA,7dIL21mRNALaughlin[7],IL21IL2lraNGF,,NGF,NGF:NGFOwolabi[8]ALE20450(NGFAtyrosinekininaseA,),L45,NGFNGFTNF2,TNF,TNF2Covey[9]:,TNFmRNA,TNF2a:TNF;1TNF,TNFa,:(1)TNF2(2)TNF2(NE)Cowey[10],TNF2NE()TNF2,TNF2NENE,TNF2,2(idozoxan),TNF2NENE,,2TNF2Ignatowski[11],NE,IL26IL28IL26IL28TNF,Ramer[12],IL26PArruda[13]IL26mRNA,IL26IL28/IL26Arruda[13]IL26IgG,IL22[14]IL22IL210,,,;IL210(CCI)NGFNGF,,.[1]TsudaM,InoueK,SalterMW.Neuropathicpainandspinalmicroglia:abigproblemfrommoleculesinsmallglia.TrendsNeurosci,2005,28:1012107.[2],..,2002,18:3662369.[3],,,.:.,2003,34:45248.[4]RittnerHL,BrackA,SteinC.Painandtheimmunesystem:friendorfoe?Anaesthetist,2002,51:3512358.[5]DeLeoJA,ColburnRW,RickmanAJ.Cytokineandgrowthfactorimmunohistochemicalspinalprofilesintwoanimalmodelsofmononeuropathy.BrainRes,1997,759:50257.[6]OkamotoK,MartinDP,SchmelzerJD,etal.Pro2andanti2inflammatorycytokinegeneexpressioninratsciaticnervechronicconstrictioninjurymodelofneuropathicpain.ExpNeurol,2001,169:3862391.[7]LaughlinTM,BetheaJR,YezierskiRP,etal.Cytokineinvolvementindynorphin2inducedallodynia.Pain,2000,84:1592167.[8]OwolabiJB,RizkallaG,TehimA,etal.CharacterizationofantiallodynicactionsofALE20540,anovelnervegrowthfac2torreceptorantagonist,intherat.JPharmacolExpTher,1999,289:127121276.[9]CoveyWC,IgnatowskiTA,KnightPR,etal.Brain2derivedTNF2alpha:involvementinneuroplasticchangesimplicatedin46320094254JClinAnesthesiol,April2009,Vol.25,No.4theconsciousperceptionofpersistentpain.BrainRes,2000,859:1132132.[10]CoweyA,StoerigP.Spectralsensitivityinhemianopicmacaquemonkeys.EurJNeurosci,1999,11:211422220.[11]IgnatowskiTA,CoveyWC,KnightPR,etal.Brain2derivedTNF2alphamediatesneuropathicpain.BrainRes,1999,841:70277.[12]RamerMS,MaW,MurphyPG,etal.Galaninexpressioninneuropathicpain:friendorfoe?AnnNYAcadSci,1998,863:3902401.[13]ArrudaJL,SweitzerS,RutkowskiMD,etal.Intrathecalanti2IL26antibodyandIgGattenuatesperipheralnerveinjury2in2ducedmechanicalallodyniaintherat:possibleimmunemodu2lationinneuropathicpain.BrainRes,2000,879:2162225.[14]SongP,ZhaoZ.Interleukin22inducedantinociceptionpartial2lycoupledwithmureceptor.Cytokine,2000,12:124021242.(:20080311):(:200723001):100049,(centralpain)(),(IASP),,,,[1],,,,,,Leijon[2]:,5075mg/d(52HT,125mg/d),1[3],,[4]Frese[4]:(75mg/d),(125mg/d,1)Vestergaard[5],(200mg/d)18,,[6]Frese[4]:(200mg/d),(1200mg/d)(FDA),[7][8],,:,,,[9]Iranami[10](50mg)(PG),,,,PGNMDANMDA,NMDA,50mg,3/,[11]NMDA,:(381mg/d439mg/d),,[12],,,NMDA,:(30min5mg/kg,56320094254JClinAnesthesiol,April2009,Vol.25,No.4