双氯芬酸钠贴片治疗骨性关节炎的有效性及安全性研究

,,,,,;;EfficacyandsafetyofdiclofenacsodiumpasteinthetreatmentofprimaryosteoarthritisofthekneeSONGShu2ju,DUANTing,LIHao2hong.DepartmentofRheumatology,BeijingFriendHospital,AffiliateofCapitalUni2versityofMedicalSciences,Beijing100050,ChinaAbstractObjectiveToassesstheefficacyandsafetyofdiclofenacsodiumpasteinthetreatmentofprima2ryosteoarthritis(OA).Methods54patientswithprimaryOAweredividedintotwogroups.Theexperimentgroupreceiveddiclofenacsodiumpaste.Thecontrolgroupreceiveddiclofenacsodium(votalin)emulgel.Patientglobalas2sessmentandtopicalpainassessment,physicianglobalassessmentandtopicalpainassessmentwerewrotedownatbaselineandafterfinalapplication.Safetywasassessedbyevaluationofadverseevents,vitalsigns,andirritationattheapplicationsite.ResultsTherewerenosignificantdifferencebetweenexperimentgroupandcontrolgroupinpatientglobalassessment,patientpainassessment,physicianglobalassessment,andphysicianpainassessment.Nose2riousgastrointestinalorrenaladverseeventswerereportedordetectedbymeansoflaboratorytesting.ConclusionDiclofenacsodiumpasteiseffectiveandsafeinthetreatmentofprimaryOA.KeywordsOsteoarthritis;Diclofenacsodiumpaste;Treatmentoutcome(OA),6570%OA,OA,(NSAIDs),,,,111111111(1)4075;(2)[1]:;X;40;30min;:100050,(3);(4)7d;(5)3;(6)11112(1);(2);(3);(4)112(),,,1(50mg),1,14d(),,,10cm,13(50mg),14d113(1),(VAS10cm)(2)18820066136ChinJPrimMedPharm,June2006,Vol.13,No.6,(VAS10cm)(3),5:(),(),(),(),()(4),:,,1;,,2;,,3(5),114(1)::30%50%;:50%70%;:70%(2):,115,,,116,,t,(ANOVA)(),2P0105221127,5,22,(601118173),27,4,23,(6018510117),,:43,:2221,:23,2121815(1),81,158,(23),(P0105)(4),(P0105)2131815(56),1(xs)1815FP51961167414211893191119133127001015173114041291174319111772817320101614011584194116131871153711016010151861145414911443153114871175701012()()(%)271893313327161140174543420:2=01318,P=015733()()(%)271982916327161140174543519:2=01731,P=013934(n=27)8158151153114521041183113511391157114211361129214421250197019411301116t01543014931100011199P0105010501050105(78),(P0105)5(,%)12314(1418)21(7718)2(714)1512(4414)14(5119)1(317)12(714)23(8512)2(714)1524(8819)3(1111)0(0)214,(9),(P0105)28820066136ChinJPrimMedPharm,June2006,Vol.13,No.69(xs)ALTCr11713516106612711477111661092719451831531888317614188611201910116116154161825170113269130714129109715714913862177231921610201930120t01297118881132301756013142175601441P0105010501050105010501050105118111101905183114066157914632149814512811573167191301410801890121116130915751681111681321013530137916613913781175201961218101820117t01670015140194711146110660145511478P01050105010501050105010501056()10421118291510150121221103231080131310153204007()8121512189019801215015120:82=21700,P0105;152=01271,P01058()812151217100198032315220:82=151565,P0101;152=161813,P01013,,,,,OA,,OAOA,,,,,,NSAIDs,OA[2],[3],,OA,,;,,2550,8,,[4],,,,,,,1,..:,2004:347.2SinghG.Treatmentoptionsforosteoarthritis.SurgTechnolInt,2003,11:2872292.3..,2003,2:3412343.4CaseJP,BaliunasAJ,BlockJA.Lackofefficacyofacetaminophenintreatingsymptomatickneeosteoarthritis:arandomized,double2blind,placebo2controlledcomparisontrialwithdiclofenacsodium.ArchIn2ternMed,2003,163(2):1692178.(:2006203229)38820066136ChinJPrimMedPharm,June2006,Vol.13,No.6