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1卡巴拉汀的生产工艺设计摘要本设计是以(S)-3-(1-二甲氨基)乙基苯酚、N-乙基-N-甲基氨基甲酰氯为主要原料的年产27吨卡巴拉汀的工艺设计。本文介绍了卡巴拉汀的性质和用途,展望了应用前景,本设计方案卡巴拉汀的总收率达到了90%。首先依据南开大学卡巴拉汀的中试研究成果,确定合成卡巴拉汀的合理工艺过程。依据工艺设计的程序,进行物料衡算,确定了本工艺适用的主要设备的规格型号,换热器的换热面积,精馏塔塔板数以及各管道的选型。综合上述工艺计算和设计结果,绘制出了带控制点的工艺流程图。在考虑操作方便、便于运输、减少房屋楼层承重等因素后,确定了车间设备的布置,绘制出了工艺设备平面布置图。为便于使该设计项目能够正确施工,还对部分管道布置进行了设计,并绘制了管道布置图。在考虑了各物料的危险特性和各设备操作条件的前提下,提出了必要的安全措施,以保证安全生产,对于排放的有害物质提出了后处理意向和方法,使排放达到国家标准,减轻对环境的危害。最后进行了工程投资与效益分析,证明本设计可行,在短期内可收回投资。关键词:卡巴拉汀工艺设计ThetechnicalprocessdesignofrivastigmineABSTRACTItwasdesignedthat27t/arivastigmineproductionlinewhichusing3-(1-dimethylaminoethyl)phenolandN-ethyl-N-methylcarbamoylchlorideasrawmaterials.Thisdissertationintroducedthepropertyanduseofrivastigmine,forecasteditsappliedforeground.Inthisdesign,theoverallyieldofrivastigminecanupto90.00%.Firstofall,accordingtotheamplificationtestresearchresultsofNaikaiUniversity,confirmthepropertechnicalprocessofrivastigmine.2Accordingtotheprocessoftechnologicaldesign,thematerialbalancecalculationwereintroducedforeachunit,theheat-exchangeareaforheatexchanger,theplatenumberofrectifyingcolumnaswellastheselectionofthepipelines.Basedontheabovetechnologicalcalculationanddesign,theconstructiondocumentsoftechnologicalprocesswithcontrolpointwasdrawn.Theabridgedgeneralviewoffactorybuildingandthefacilityfloorplaneachfloorweredesignedanddrawnaftertheconsiderationsofthehandlingconvenience,transportationconvenienceandtheheightofthefloor.Inordertoconstructexactly,somepipinglayoutwasdesignedanddrawn.Becauseoftheriskofmaterialandserviceconditionsoffacility,thedissertationpresentedthenecessarysafepracticeinordertoguaranteesafetyinproduction.Thedissertationalsopresentedtheaftertreatmentintentionandmethodtoharmfulsubstanceinordertolightenenvironmentalcontamination.Atlast,thedissertationtestifiedthatthedesignwasfeasibleandinvestcouldbeevictedinshorttimeaccordingtotheconstructioninvestandbenefitanalysis.KeyWords:RivastigmineTechnologyDesign3目录第一章前言............................................................11.1卡巴拉汀的性质......................................................11.2卡巴拉汀的用途......................................................11.3卡巴拉汀的生产及应用前景............................................2第二章设计说明书.....................................................42.1本设计采用路线......................................................42.2设计目的及任务.....................................................42.2.1设计目的及意义........................................................42.2.2设计任务...............................................................52.3基本工艺流程................................................................52.4基本数据....................................................................72.5物料衡算....................................................................82.6设备选型及设计.............................................................92.6.1换热器的传热面积计算及选型...........................................92.6.2精馏塔的设计.........................................................102.6.3反应釜选型...........................................................142.6.4各主要管道的设计....................................................152.7工艺流程设计说明.........................................................172.8平面布置设计说明.........................................................182.9管道设计说明..............................................................18第三章安全生产和环境保护............................................193.1物料的安全要求...........................................................193.2安全生产的基本要求.......................................................193.3设备及检修的安全注意事项................................................203.4环境保护.................................................................21第四章经济效益评价...................................................224.1原料消耗定额.......................................................224.2单位产品原料费用估计...............................................224.3投资及收益估算.....................................................244.3.1设备..........................................................2444.3.2公用工程......................................................244.3.3安装费........................................................244.3.4生产厂房......................................................244.3.6销售收入......................................................24第五章结论.............................................................25参考文献................................................................26附表................................................................27附图................................................................28致谢................................................................291第一章前言1.1卡巴拉汀的性质产品名称:卡巴拉汀系统命名:N-乙基-N-甲基-氨基甲酸-3-[(S)-1-(二甲氨基)乙基]苯酯别名:利凡斯的明,艾斯能[1]英文名称:Rivastigmine分子式:C14H22N2O2结构式:分子量:250.34熔点:123-125℃(酒石酸盐)水溶性:2.04e+00mg/mL1.2卡巴拉汀的用途卡巴拉汀(rivastigmine)又名利凡斯的明。属第二代中枢AChE抑制药,对大鼠大脑皮层和海马的AChE有选择性抑制[2]作用,而对纹状体和心脏的AChE几无影响,尚可减慢淀粉样蛋白前体(APP)的形成。口服迅速吸收,约1h达到Cmax,血浆蛋白结合率约40%,已透过血脑屏障,临床用于轻、中度阿尔茨海默症(老年痴呆症),改善认知功能障碍,提高记忆力、注意力和方位感。主要使用其重酒石酸盐进行治疗。阿尔茨海默病(Alzheimerdisease,AD),又叫老年性痴呆[3],是一种中枢神经系统变性病,起病隐袭,病程呈慢性进
本文标题:卡巴拉汀的生产工艺设计
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