您好,欢迎访问三七文档
当前位置:首页 > 医学/心理学 > 药学 > 富血小板血浆-PRP-与软骨的修复
2010313NO,,,,:2010-04-0220%12(1.1570112.157011),[1]200920%80,11.1,[2],18~45,25,1~10a,120.5d,91,28,,,,,80,391.2,20%,10%,1.3;50%,;30%;,22.1,1,1,2.26,4,2~3,180262624495.00%39210111658.97%:P0.013,20%,,80,(1),,(2):,(3):[1],.[J].,2004,2(6):33.[2].[J].,2004,3(1):66.:2010-05-06(PRP)(157011):(PRP):,PRP(2000-048)!83!JOURNALOFMUDANJIANGMEDICALUNIVERSITYVol31NO320102010313,PRP:PRP:PRP,PRP:PRP,(PRP);;;,,,,[1],,(platelet-richplasma,PRP),,PRPPRP,,PRP1(PRP)PRP,,,PRP,[2]PRPPRP,,,,(platelet-poorplasma,PPP),,,,,,,,PRPPRP(),,6~10s,PRP,PRP(platelet-richge,lPRG)PRP,,,PRP,,,-(transforminggrowthfactor-,TGF-)(plateletderivedgrowthfactor,PDGF)(insulin-likegrowthfactor,IGF)(fibroblastgrowthfactor,FGF)(vascularendothelialgrowthfactor,VEGF)[3][4],:TGF-,[5]TGF-:∀,;#,IITGF-,[6]IGF,,IGFIGF-∃IGF-%,[7]FGFbFGFaFGF,,[8]FGFTGF-1,,VEGF,[9]VEGF[10]PDGFPDGF,,[11]22.130d,,,,[12][13],8,,,8X,,,,,,,,,,2.2,17-,RNA,,,,Silva[14]-1,!84!JOURNALOFMUDANJIANGMEDICALUNIVERSITYVol31NO320102010313-1,,,,2.3,,:,,,,2.4Homminga[15],,,,,,,,,2~5a,2.5,,,,,,[15]2.6,,,[16],FDA,2.7[17](FGF)-(TGF-)(IGF)(PDGF)(BMP),,[18],3(PRP)PRP,[19],(microfracture)(subchondraldrilling)(periosteumandperichondriumgrafts),,,,,,[20],,PRP,PRP,,PRP,,PRP,PRP,,PRP,,,PRP[1]HunzikerEB.Articularcartilagerepair:basicscienceandclinicalprogress.Areviewofthecurrentstatusandprospects[J].OsteoarthritisCartilage,2002,10(6):432-463.[2],.[J].,2004,8(35):7939-7941.[3]MarxRE.Platelet-richplasma(PRP):WhatisPRPandwhatisnotPRP?[J].ImplantDentistry,2001,10(4):225-228.[4],,.[J].,2002,6(22):3369-3370.[5].-1[J].,2003,16(3):159-161.[6]Garcia-MolinaJA,Vallespi-MiroG,Theroleoffibroblast!85!JOURNALOFMUDANJIANGMEDICALUNIVERSITYVol31NO320102010313growthfactor(FGF)andtypebetatransforminggrowthfactor(TGF-beta1-beta2-beta3)duringratcraniofacialdevelopment[J].BullGroupIntRechSciStomatolOdonto,l2003,45(23):66-78.[7]LongobardiL,OR'earL,eta.lEffectofIGF-IinthechondrogenesisofbonemarrowmesenchymalstemcellsinthepresenceorabsenceofTGF-betasignaling[J].JBoneMinerRes,2006,21(4):626-636.[8]MadryH,EmkeyG,ZurakowskiD,eta.lOverexpressionofhumanfibroblastgrowthfactor2stimulatescellproliferationinanexvivomodelofarticularchondrocytetransplantation[J].GeneMed,2004,6(2):238-45.[9]MarxRE.Platelet-richplasma:Evidencetosupportitsuse[J].JOralMaxillofacSurg,2004,62(4)&489-496[10]DuanXJ,YangL,LiQH.Molecularmechanismofsynergismofangiogenesisandboneregeneration[J].LinchuangGukeZazhi,2005;8(1):88-91.[11],,.-BB[J].,2005,85(46):3297-3298.[12],.[J].,2003,6(4):380-383.[13],.[J].,2003,34(4):49-51.[14],,.[J].(),2004,25(6):584-586.[15]HangodyL,FulesP.Autologousosteochondralmosaicplastyforthetreatmentoffull-thicknessdefectsofweight-bearingjoints:tenyearsofexperimentalandclinicalexperience[J].JBoneJointSurg(Am),2003,85(2):25-32.[16],,.[J].,2005,13(8):617-619.[17],.[J].(),2004,27(5):5-8.[18]WaltherM,HarmsH,KrennV,etal.Correlationofpowerdopplersonographywithvascularityofthesynovialtissueofthekneejointinpatientswithosteoarthritisandrheumatoidarthritis[J].ArthritisRheum,2001,44(2):331-338.[19]MazorZ,PelegM,GargAK,eta.lPlatelet-richplasmaforbonegraftenhancementinsinusflooraugmentationwithsimultaneousimplantplacement:patientseriesstudy[J].ImplantDentistry,2004,13(1)&65-72[20]SmithGD,KnutsenG,RichardsonJB.Aclinicalreviewofcartilagerepairtechniques[J].JBoneJointSurg,2005,87-B(4):445-459.:2010-03-29112(1.157000;2.158100),,,,;;,,,,,,,,,,,,,,,,∋(,,,[1];,,,[2],,,,:1[3],,,DNA,,Ca2+!86!JOURNALOFMUDANJIANGMEDICALUNIVERSITYVol31NO32010
本文标题:富血小板血浆-PRP-与软骨的修复
链接地址:https://www.777doc.com/doc-1364835 .html