年产XXXX万支250ml糖浆剂生产车间工艺设计

北京理工大学珠海学院布洛芬糖浆剂工艺设计题目：年产2000万支250ml糖浆剂生产车间工艺设计学生姓名：陈塨慧、苏泽鹏、萧志乐蔡权、冯宇学院：化工与材料学院专业班级：12应用化学2班2015年10月北京理工大学珠海学院16届本科生课程设计I年产2000万支250ml糖浆剂生产车间工艺设计摘要依据GMP的思想，为布洛芬糖浆生产提供合理的生产工艺与车间布局。根据糖浆制剂车间设计的原则和规定科学有效地设计出年产2千万支250ml布洛芬糖浆的生产车间。对处方的设计、糖浆制剂工艺流程的设计以及物料衡算、工艺设备选型、车间设计和成本估算等进行了详细的研究和分析，并最终设计出有效可行的年产2千万支250ml布洛芬糖浆生产车间工艺。本设计严格遵守GMP规定，符合环保、经济、安全、技术等方面的要求。关键词：GMP；布洛芬糖浆；生产工艺；车间布局北京理工大学珠海学院16届本科生课程设计IAnannualoutputof20million-250mlibuprofensyrupprocessdesignworkshopAbstractAccordingtothethoughtofGMP,providetheproductionprocessandworkshoplayoutreasonableforibuprofensyrupproduction.Accordingtotheprinciplesandprovisionsofthesyruppreparationworkshopdesignscienceeffectivelydesignanannualoutputof20millionpiecesof250mlofibuprofensyrupproductionworkshop.Theformulationdesign,injectionprocessdesignandthematerialbalance,processequipmentselection,workshopdesignandcostestimationofthedetailedresearchandanalysis.Andthefinaldesignofanannualoutputof20000000effective250mlibuprofensyrupproductionprocess.ThisdesignstrictlyabidebytheprovisionsofGMP,withtheenvironmentalprotection,economy,safety,technologyandotheraspectsoftherequest.Keywords:GMP；ibuprofensyrup；productionprocess；workshoplayout北京理工大学珠海学院16届本科生课程设计I目录1前言..........................................................................11.1布洛芬糖浆剂的介绍.....................................................11.1.1布洛芬的适应症..................................................11.1.2布洛芬的介绍....................................................11.1.3布洛芬的主要剂型................................................21.1.4糖浆剂介绍......................................................21.1.5糖浆剂的特点....................................................21.1.6糖浆剂剂的分类..................................................21.1.7糖浆剂的规格和质量..............................................21.1.8糖浆剂在制备与贮藏过程中易出现的问题............................32制剂规格、处方研究...........................................................42.1制剂规格设计...........................................................42.2实验室制法.............................................................42.3处方分析...............................................................52.3.1主药布洛芬的处方分析............................................52.3.2粘度控制剂处方分析..............................................52.3.3甜味剂..........................................................52.3.4悬浮剂..........................................................52.3.5乳化剂..........................................................62.3.6PH控制剂.......................................................63工艺流程设计.................................................................63.1工艺流程图.............................................................64物料衡算.....................................................................74.1参数设计...............................................................74.2原辅料物料衡算.........................................................74.3各工序物料进出计算....................................................104.4包装材料物料衡算......................................................114.4.1内包材料物料衡算...............................................114.4.2外包材料物料衡算...............................................12北京理工大学珠海学院16届本科生课程设计II4.4.3标签说明书物料衡算.............................................124.4.4物料衡算总表...................................................125主要生产设备选型............................................................135.1纯水设备选型..........................................................145.2溶糖锅设备选型........................................................145.3配液罐设备选型........................................................155.4过滤设备选型..........................................................155.5泵设备选型............................................................155.6ph计设备选型.........................................................165.7封口机设备选型........................................................165.8激光打码机设备选型....................................................175.9灯检工作设备选型......................................................175.10洗瓶设备选型.........................................................175.11灭菌设备选型.........................................................185.11印字贴标设备选型.....................................................185.12理瓶设备选型.........................................................196生产工艺流程概述............................................................216.1称量与筛分............................................................216.2配料...................................................错误!未定义书签。6.3过滤...................................................错误!未定义书签。6.5灌封与灭菌.............................................错误!未定义书签。6.6糖浆瓶的洗涤...........................................错误!未定义书签。6.7包装...................................................错误!未定义书签。6.8工艺流程说明...........................................错误!未定义书签。7成本估算....................................................................237.1原辅料及包装材料成本估算..............................................237.1.1原辅料成本估算.................................................237.1.2包装材料成本估算............................................