脑小血管病诊治专家共识-脑小血管病诊治专家共识组

CSVD。CSVD。CSVD、、、1－2CSVD。《》、《》CS-VD、、、CSVD。、40～200μm、。CS-VD、、1。。CSVD、、LI、lacune、WML、CMB1－3。、LI4－51。3～15mm。LI3～20mmMＲI。2LI“”。“”。3lacunarsyndrome。LIlacunarischemicstroke6。4、、“”、“”。CSVDCSVD。、CSVD。OCSP7442．3%825%～30%。TOAST92007～2008SAO17．2%1025%。5～6。8%～28%2%～3%6。WMLCMBWML50%～98%67%～98%AD28．9%～100%2。CMB11%～25%11。CSVD、、、、TIA2。CSVD。DOI10．3760/[e-mail]4884《》2014421、1－41．arteriolosclerosismicroatheroma、、。、、。2．CAA、CADA-SILCSVD、、FabryCSVD。1－41．2～5、、、、、。LI。2．WML。1μ20．2～2．9mm。3．CMB。、、CAA、。4．WMLCSVD。、CSVD12CSVD3。3。1234、、125β。。CSVD。、、、。、。、1．CSVD。LI、、、。。CS-VDWMLWML。LI13－14。、WMLCMB15－17。2．CSVD、、。CSVDVCI12VaMCI12VaD36%～67%18。。WML19。CSVD、、vasculardepression。3．CSVD、。、、、、、20。WML、、。LADIS600WMLWML、19%、15%26%WML220。、1．WML。MＲIT1、FLAIＲT2。5885《》2014421MＲI“”WMHWML。WML。2．LI－、、、21。MＲIT1、T2DWI1。3．CMBCMBMＲIT2。、、122。。4．MＲI、＜3mmT1、T2、FLAIＲ。、1．CSVDLI。MＲI。2．CSVDVCI12。。CSVD。CSVD。、、、、CSVDWML、CSVD。3．CSVDWML、LI、CMBCSVD14CSVDWML2434CSVD。CTCSVDCT“”。。CSVDCS-VD。、1．CSVD、、。WMLCMBLI。2．CSVD、。CSVD12。23。。。。SPS32423。、CSVD。25。CSVD。VaD26。VaD6886《》201442127。28。VCI、、。5－。。。WMLCMBWML。1300WML4WML29。WML30。CMBCSVD。CMB31。、、、、、CS-VDCSVDVCI312。、、、、B。、CSVD、、。。。CSVD、、、。。。1WardlawJMSmithCDichgansM．Mechanismsofsporadiccerebralsmallvesseldiseaseinsightsfromneuroimaging．LancetNeurol201312∶483－497．2MoranCPhanTGSrikanthVK．Cerebralsmallvesseldiseaseare-viewofclinicalradiologicalandhistopathologicalphenotypes．IntJStroke20127∶36－46．3PantoniL．Cerebralsmallvesseldiseasefrompathogenesisandclini-calcharacteristicstotherapeuticchallenges．LancetNeurol20109∶689－701．4BaileyELSmithCSudlowCLeta1．Pathologyoflacunarischemicstrokeinhumans-asystematicreview．BrainPathol201222∶583－591．5WardlawJM．Whatisalacune．Stroke200839∶2921－2922．6SaccoＲLKasnerSEBrodenckJPeta1．Anupdateddefinitionofstrokeforthe21stcenturyastatementforhealthcareprofessionalsfromtheAmericanHcartAssociation/AmefieanStrokeAssociation．Stroke201344∶2064－2089．7BamfordJSandercockP．JonesLeta1．ThenaturalhistoryofIacu-narinfarctiontheOxfordshireCommunityStrokeProject．Stroke198718∶545－551．8WuBLinSHaoZeta1．Proportionriskfaetorsandoutcomeofla-cunarinfaretionahospital-basedstudyinaChinesepopulation．Ce-rebrovascDis201029∶181－187．9AdamsHPJrBendixenBH．KappelleLJeta1．Classificationofsub-typeofacuteischenficstroke．Definitionsforuseinanmltieenterclinicaltrial．TOAST．TrialofOrg10172inAcuteStrokeTreatment．Stroke．199324∶35－41．10XuJLiuLWangYeta1．TOASTsubtypesitsinfluenceupondoc-tors’decisionsofantihypenensiv8prescriptionatdischargeforische-micstrokepatients．PatientPreferAdherence20126∶911－914．11PodsMMIkramMAvanderLugtAeta1．IncidenceofcerebralmicrobleedsinthegeneralpopulationtheＲotterdamScanStudy．Stroke201142∶656－661．12GorelickPBScutefiABlackSEeta1．Vascularcontributionstocognitiveimpairmentanddementiaastatementforhealthcareprofes-sionalsfromtheAmericanHcartAssociation/AmeficanStrokeAsso-ciation．Stroke201142∶2672－2713．13VermeerSELongstrethWTJrKoudstaalPJ．Silentbraininfarctsasystematicreview．LancetNeurol20076∶611－619．14ArboixAMartl-VilallaJL．Lacunarstroke．ExpenＲevNeurother20099∶179－196．15FuJHChenYKChenXYeta1．Coexistingsmallvesseldiseasepredictspoorlong-termoutcomeinstrokepatientswithintracraniallargearteryatherosclerosis．CerebrovascDis201030∶433－439．16DebetteSMarkusHS．Ttleclinicalimportanceofwhitematterhyper-intensitiesonbrainmagneticresonanceimagingsystematicreviewandmeta-analysis．BMJ2010341∶c3666．907887《》2014421。SDAVF、。1ＲodeschGHurthMAlvarezHetal．Angio－architectureofspinalcordarteriovenousshuntsatpresentation．Clinicalcorrelationsinadultsandchildren．TheBicêtreexperienceon155consecutivepatientsseenbetween1981－1999J．ActaNeurochirWien20041463∶217－226．2MuraszkoKMOldfieldEH．VascularmalformationsofthespinalcordandduraJ．NeurosurgClinNorthAm19901∶631－652．3QuencerＲMDonovanPostMJ．SpinalcordlesionsinpatientswithAIDSJ．NeuroimagingClinNorthAm19977∶359－373．4WillinskyＲTerBruggeKLasjauniasPetal．Thevariablepresenta-tio．ofcraniocervicalandcervicalmalformationsJ．SurgNeurol199034∶118－123．5．DSAJ．2003221∶61－63．6YasargilMGSymonLTeddyPJ．Arteriovenousmalformationsofspi-nalcordJ．AdvTechStandNeurosurg19847∶6－102．2013－10－21··。《》、《》、。10、。SCI2。“”、2。8717LovelockCECordonnierCNakaHeta1．Antithromboticdrugusecerebralmicrobleedsandintracerehralhemorrhageasystem-aticreviewofpublishedandunpublishedstudies．Stroke201041∶1222－1228．18ＲektorIＲektorovdIKubováD．Vascularparkinsonism-anup-date．JNeurolSci2006248∶185－191．19ChuiH．Dementiaduetosubcorticalischemicvasculardisease．ClinCornerstone20013∶40－51．20LADISStudyGroup．2001－2011adecadeoftheLADISLeuko-araiosisAndDISabilityStudywhathavewelearnedaboutwhitenlatterchangesandsmall-vesseldisease．CerebrovascDis201132∶577－588．21ZhuYCDufouilCTzourioCetal．SilentbraininfarctsareviewofMＲIdiagnosticcriteria．Stroke201142∶1140－1145．22GreenbergSMVernooijMWCordonnierCeta1．Cerebralmicrob-leedsaguidetodetectionandinterpretation．LancetNeurol20098∶165－174．23FurieKLKasnerSEAdamsＲJeta1．Guidelinesforthepreven-tionofstrokeinpatientswithstrokeortransientischemicattackagu