醋酸亮丙瑞林治疗女童真性性早熟

100%2,,148h(Hb145g/L)3(%)30%50%100%65(58.33)1(16.66)0(0)1411(78.58)2(14.28)1(7.14)86(75.00)1(12.50)1(12.50)2822(78.57)4(14.28)2(7.15)3,,,,,,72h(7816%)30%50%,24h,,,,,,Hct0180,,,,,,,1,,,,,3:;;,212h24h,1,,,..3.:,2003.6982,,..:,1999.98100(:2004-10-08:)(528000),1860100g/kg,2830d1,6,,:BA/CA();3,6,,BA/CA,;,;4;,,,(leuprorelinacetate)(GnRH-a),(),,,111120001200438(),(GnRH-a)618,6,26,516815,(7165013),(CA)711917,(7198115);Tanner,3,913;3MRI8622GuangdongMedicalJournalFeb.2005,Vol.26,No.2112[1]:8,Tanner10;BACA2,2;,3mm,,4mm;(E2)38pmol/L,(T)018nmol/L;LHRH(LH)12mU/L11318,:A()8100g/kg(3175mg),2830d,10g/kg7080g/kg;B10():100g/kg,3100g/kg,260g/kg,2830d6,26,1131141;LHFSHE2B1Tanner[1]CHN(),,;(BA)/(CA)BA/CA;(BA)/(CA)BA/CA[1]11511511GnRHLHRH()100g/m2,1hLH,FSHE21.5.2B-250(SI-250),V=()1/2,014cm115131985;-(B-P):=(+-13)/2116t,t221118,BA/CA(),3(8151013),(90100g/kg),012cm,,4,1,416kg/312126,LH,FSH,E2T,;LH,FSH,E2(P0105)2118€xstP(cm)126.3219131.33112.580.05(kg)2321826.12182.510.05()7.981158.5411472.40.05(cm/)4.360162.301433.20.01()9.87015410.0801362.280.05BA/CA1.3401211.120112.310.05(cm)155.8318158.96152.040.052(n=11)€xstPLH(mIU/ml)18.67.25.12.12.210.05FSH(mIU/ml)12.83.453.01.12.470.05E2(pg/ml)53.28.78.74.23.610.0121318,13,(417112)cm,;12,44014cm,,33(€xs)cm2tP4.11.72.81.13.190.012.31.41.61.42.330.052.21.51.51.22.540.052143,18,;618,943215,,(GV),AGVB(P0105),A,B(P0105)LHFSH(P0105),B,444GVLHFSHA81.90.319.970.544.83.13.011.025.92.4B102.30.4310.060.464.72.12.90.526.11.9P0.050.050.050.050.05722200522622.69,,,,,93(CPP)--(HPGA),9,810CPPN[1]:,,,GnRH,GnRH,GnRH,,FSH,LH,,,BA/CA,[2]18,:,,,BA/CA()(P0105)(PAH),,/,:6,LH,LH/FSH,E2,,;,,,[3],3(8151013)(90100g/kg),012cm,,4,60g/kgGH,,GnRH:GnRH,,,,(12)[5];GnRHGHGH,,GH[4];[6],3:,B102(10010g/kg),60g/kg,9,;A8(10010g/kg)10g/kg60g/kg26,,A,(B4B5)21,(60g/kg)(015cm/),LH,LH/FS,,,,0158kg/,Palmert[7],,,,,,,,1,..:,2001.1252TanakaT,SatohM,YasunagaT,etal.GHandGnRHanalogtreatmeatinchildwhoenterpuberatshortstature.JPediatrEndocrinolMetab,1997,10(6):6233,,,.10.,2003,21(9):5734MeirLM,AvrahamG,HadassahG,etal.Estrogenmini-dosereplace2mentduringGnRHagonisttherapyincentralprecociouspuberty:apilotstudy.ClinEndocrinolMetab,2002,87(2):6875LaronZ,KauliR.Experiencewithcyproteroneacetateinthetreatmentofprecociouspuberty.JPediatrEndocrinolMetab,2000,13(1):8056KleinKO,BarnesKM,JonesJV,etal.Increasedfinalhightinpreco2ciouspubertyafterlong-termtreatmentwithLHRHagonists:thenatuinalinstitutesofhealthexperience.JClinEndocrnolMetab,2001,86(10):47117PalmertMR,MansfieldMJ,GrowleyWF,etal.Isobesityanoutcomeofgonadotropin-releasinghormoneagonistadministration?Analysisofgrowthandbodycompositionin110patientswithGnRHanalogtreatmeatinchildwhoenterpuber.JPediatr,2001,134(5):812(:2004-10-16:)822GuangdongMedicalJournalFeb.2005,Vol.26,No.2