细菌群体感应与细菌生物被膜形成之间的关系-刘琳

Mini-ReviewActaMicrobiologicaSinica523271－2784March2012ISSN0001－6209CN11－1995/Qhttp//journals．im．ac．cn/actamicrocn3117013131070312*。[e-mail]。[e-mail][e-mail]2011-08-302012-01-1312#1#1*12100942518083。80%。。。Q814A0001-6209201203-0271-08。Biofilm、、、1。、。QuorumsensingQS。。、QSQS。Pseudomonasaeruginosa、Escherichiacoli、Staphylococcusaureus。2－3、4、5Klebsiellapneumoniae6QS。。LinLiuetal．/ActaMicrobiologicaSinica20125231QS2070Vibriofisheri。1994Fuqua7。autoinducerAI。AIAI、、、、。。。QSQS。LuxIQSN-N-acylhomoserinelactoneAHLs。AHLsAHLsAHLsLuxR。AHLsN-C-3。LuxIAI3-oxo-C6-HSL3-oxo-C6-HSL7。Antunes83-oxo-C6-HSL18LuxR-3-oxo-C6-HSL。QS9。RNA-seqcDNA10QS。QSAHL-QSlasR-lasIrhlR-rhlI11。LasI3-oxo-C12-HSLLasRLasR-。LasRRhlR-RhlIRhlIC4-HSL12。QSpqs13AI2--3--4-PseudomonasquinolonesignalPQSpqsABCD。PqsRPqsEPQS。PqsErhlPQS。PQS。QSDNA。。。agr。agrDAIPAgrCAgrA14。AgrBAIPAIPAgrCAgrCAgrA。AgrARNAⅢRNAⅢ、。agrAagrBDCA。QS—VibrohaveryiQS。QSAHLAI-1。AI-2。AI-13--C4-HSLLuxLM。AI-2LuxS。AI-1AI-2LuxNLuxQLuxULuxULuxOLuxOLuxCDABE272．/2012523。AI-1AI-2LuxNLuxQLuxNLuxQLuxNLuxQLuxULuxOLuxOLuxOLuxCDABE。217Leeuwenhoek1978Costerton。AnnuRevMicrobiol、、、。。AHL。AHLAHLSDS。AHL。AHL。。15。。65%80%16。。“β-”。。。。17。Rahmati18Candidaalbicans。3QS1991Davies19QS。QS。、。、、。QS20。QS21。22、。、。。QS。1998Davies19SciencelasQS372LinLiuetal．/ActaMicrobiologicaSinica201252321。lasAHL、、20。AHL-QSlasI/RrhlI/R3-oxo-C12-HSLC4-HSL1。rhl1QSFig．1TherelationshipbetweenquorumsensingQSandbiofilmBFofGram-negativebacteriaP．aeruginosaFig．1wasdrawnbyauthorsthemselves．Octagonrepresentssystemroundedrectanglerepresentsgenepentagonrepresentsproteinfoldangleellipserepresentsautoinducercurveedgesquadrilateralrepresentscombinationofautoinducerandreceptorrectanglerepresentsgeneexpression．23las、。DaveyO'Toole24。DaveylasI-lasRDekimpe12rhlABrhlCRhlRrhlABrhlC。DevayDekimpelasRrhlRlasRRhlRLasRlas。las3-oxo-C12-HSLSDSSDS。3-oxo-C12-HSLSDS。QS25。QS—pqsPQSpqsABCD1。QS。BurkholderiacepaciaH111cepI/RQS26。AeromonashydrophilaahyR/Iacyl-HSLQS27。YersiniapseudotuberculosisQSYpsR/IYtbR/I。ypsRypsI28。VibrocholeraeQS472．/2012523vps29。QS。QS。30。S．epidermidis7。。。Kiran31QS。QSSQS1SQS22。SQS1RNAⅢ-RAPTRAP。SQS1SQS2SQS2agr-AgrCmRNARNAⅢ。RAPanti-RAPanti-TRAP、RAP、RNAⅢRIP。TRAP。QS。2QSFig．2TherelationshipbetweenquorumsensingQSandbiofilmBFofGram-positivebacteriaS．aureusFig．2wasdrawnbyauthorsthemselves．Octagonrepresentssystempentagonrepresentsproteinfoldangleellipserepresentsregulatorcurveedgesquadrilateralrepresentscombinationofautoinducerandreceptorrectanglerepresentsgeneexpressionellipserepresentspeptide．QS。QSQS、、、、。。QS。21QSQS。QS。QS。QS。4QS。QSQS。QSAIAIQS。5。TUE1、TUE2、RES1、RES2、RES3572LinLiuetal．/ActaMicrobiologicaSinica20125235TUE1TUE22。QS1QS。AHL。DKPs32－342。、、。35。QS3QSAIAIQSQS。36QS。Jin-HyungLee373-O157H7。Kiran32QSRNAⅢ。MethicillinresistantS．aureusMRSAMRSE。4“”。QS“”。1．．JournalofMicrobiology201030180-83．2HentzerMRiedelKRasmussenTBHeydornAAndersenJBParsekMRRiceSAEberLMolinSHibyNKjellebergSGivskovM．InhibitionofquorumsensinginPseudomonasaeruginosabiofilmbacteriabyahalogenatedfuranonecompound．Microbiology2002148187-102．3PiletskaEVStavroulakisGLarcombeLDWhitcombeMJSharmaAPrimroseSRobinsonGKPiletskySA．PassivecontrolofquorumsensingpreventionofPseudomonasaeruginosabiofilmformationbyimprintedpolymers．Biomacromolecules20111241067-1071．4LeeJMaedaTHongSHWoodTK．Reconfiguringthequorum-sensingregulatorSdiAofEscherichiacolitocontrolbiofilmformationviaindoleandN-AcylhomoserineLactones．AppliedandEnvironmentalMicrobiology20097561703-1716．5KongKFVuongaCOttoM．Staphylococcusquorumsensinginbiofilmformationandinfection．InternationalJournalofMedicalMicrobiology20062962-3133-139．6AraujoCDBalestrinoDRothLCharbonnelNForestierC．QuorumsensingaffectsbiofilmformationthroughlipopolysaccharidesynthesisinKlebsiellapneumoniae．ResearchinMicrobiology20101617595-603．7Brelles-MarioGBedmarEJ．Detectionpurificationandcharacterisationofquorum-sensingsignalmoleculesinplant-associatedbacteria．JournalofBiotechnology2001912-3197-209．8AntunesLCMSchaeferALFerreiraRBRQinNStevensAMRubyEGGreenbergEP．TranscriptomeAnalysisoftheVibriofischeriLuxR-LuxIRegulon．JournalofBacteriology2007189228387-8391．9QinNCallahanSMDunlapPVStevensAM．AnalysisofLuxRRegulonGeneExpressionduringQuorumSensinginVibriofischeri．JournalofBacteriology2007189114127-4134．672．/201252310．．ActaMicrobiologicaSinica2011514445-457．11RudrappaTBaisHP．CurcumnaknownPhenolicfromCurcumalongaAttenuatestheVirulenceofPseudomonasaeruginosalPAO1inwholePlantandAnimalPathogenicitymodels．JournalofAgriculturalandFoodChemistry20085661955-1962．12DekimpeVDe'zielE．Revisitingthequorum-sensinghierarchyinPseudomonasaeruginosathetranscriptionalregulatorRhlRregulatesLasR-specificfactors．Microbiology20091553712-723．13AntunesLCMFerreiaRBRBucknerMMCFinlayBB．Quorumsensinginbacterialvirulence．Microbiology201015682271-2282．14GeorgeEANovickRPMuirTW．CyclicPeptideInhibitorsofStaphylococcalVirulencePreparedbyFmoc-BasedThiolactonePeptideSynthesis．JournaloftheAmericanChemicalSociety2008130144914-4924．15．．JournalofClinicalRehabilitative