第四章《抗体》练习题

第四章《抗体》练习题一、单项选择题1．抗体与抗原结合的结构域是················································（）A、VHB、VLC、CHD、VH和VL2．IgG与C1q结合的结构域是················································（）A、CH1B、CH2C、CH3D、VH和VL3．IgM与C1q结合的结构域是················································（）A、CH1B、CH2C、CH3D、VH和VL4．IgG与吞噬细胞或NK细胞表面FcR结合的结构域是··························（）A、CH1B、CH2C、CH3D、VH和VL5．血清中含量最高的Ig是···················································（）A、IgAB、IgMC、IgGD、IgD6．与抗原结合后激活补体能力最强的Ig是·····································（）A、IgAB、IgMC、IgGD、IgD7．能通过胎盘的Ig是·······················································（）A、IgAB、IgGC、IgMD、IgE8．脐血中含量增高提示胎儿有宫内感染的Ig是·································（）A、IgAB、IgMC、IgGD、IgD9．在初次感染病原微生物后，机体最早产生的抗体是·····························（）A、IgAB、IgMC、IgGD、IgD10．分子量最大的Ig是······················································（）A、IgAB、IgMC、IgGD、IgD11．新生儿从母乳中获得的抗体是·············································（）A、IgAB、IgMC、IgGD、SIgA12．产生抗体的细胞是·······················································（）A、T细胞B、B细胞C、浆细胞D、NK细胞13．sIgA的组成为··························································（）A、二个IgA单体与一个J链B、二个IgA单体与一个J链和一个分泌片C、一个IgA单体与一个J链D、一个IgA单体与一个J链和一个分泌片14．能与肥大细胞表面FcR结合，介导Ⅰ型超敏反应的Ig是·······················（）A、IgAB、IgMC、IgGD、IgE15．天然ABO血型抗体属于··················································（）A、IgAB、IgMC、IgGD、IgD16．具有J链结构的Ig是·····················································（）A、sIgA、IgGB、IgM、sIgAC、IgG、IgDD、IgD、IgE17．J链合成缺陷后受影响的Ig是·············································（）A、IgG和IgEB、IgMC、IgAD、IgM和sIgA18．参与黏膜局部抗感染的Ig是··············································（）A、IgAB、IgMC、sIgAD、IgG19．抗体分子基本结构的组成是···············································（）A、2条重链和2条轻链B、1条重链和1条轻链C、2条相同的重链和2条相同的轻链D、4条相同的肽链20．下列不属于抗体的功能为·················································（）A、与抗原结合B、激活补体C、杀灭细胞D、调理作用21．合成sIgA分泌片的细胞是················································（）A、巨噬细胞B、血管内皮细胞C、浆细胞D、黏膜上皮细胞22．IgG易被蛋白水解酶作用的部位是·········································（）A、铰链区B、VH和VLC、CH1D、CH223．成熟B细胞的BCR的Ig类型是············································（）A、mIgA和mIgMB、mIgM和mIgDC、mIgG和mIgED、mIgE和mIgD24．具有CH4结构域的Ig为··················································（）A、sIgA和IgMB、IgM和IgDC、IgM和IgED、IgE和IgG25．关于抗体，下列描述错误的是··············································（）A、抗体都是球蛋白B、抗体主要存在于体液中C、抗体能与相应抗原特异性结合D、抗体由浆细胞产生26．介导NK细胞等效应细胞产生ADCC效应的Ig主要是·························（）A、IgAB、IgDC、IgGD、IgM27．关于Ig的铰链区，下列表述错误的是·······································（）A、位于CH1和CH2之间B、富含脯氨酸C、易于伸展弯曲D、五类Ig铰链区相同28．sIgA分子中分泌片的主要功能是··········································（）A、连接2个IgA单体B、维持sIgA的立体构象C、保护sIgA免遭蛋白酶的水解D、促进抗体与抗原的结合29．抗体发挥中和毒素作用主要依赖其·········································（）A、C区的作用B、调理作用C、ADCC作用D、V区的作用30．IgM的实际抗原结合价为·················································（）A、1价B、2价C、5价D、10价二、填空题1．抗体分子的基本结构是由两条相同的和两条相同的通过链间__________连接而成的四肽链结构。2．IgA、IgM、IgG、IgE、IgD相应的重链分别为、、、、。3．五类Ig中，血清含量最高的是，具有J链和分泌片的是，分子量最大的是，能介导Ⅰ型超敏反应的是，能通过胎盘的是。4．免疫球蛋白轻链可分为型和型。5．用木瓜蛋白酶水解IgG可得到两个相同的片段和一个片段；用胃蛋白酶水解IgG可获得一个能与抗原结合的片段和无生物学活性的片段。6．IgG铰链区位于与之间的区域，其补体（C1q）结合点位于。7．具有J链结构的免疫球蛋白有和。8．sIgA由二个IgA单体与和组成，主要存在于外分泌液中，在局部黏膜免疫中发挥重要作用。三、名词解释抗体IgCDR独特型（Id）抗体的调理作用ADCC作用单克隆抗体基因工程抗体四、简答题1．简述免疫球蛋白的基本结构。2．简述IgG分子的结构域组成及各结构域分别有何功能。3．试述IgG的主要免疫学特性及功能。4．试述IgM的主要免疫学特性及功能。5．试述sIgA的分子结构组成、分布及主要免疫学功能。五、问答题1．试述抗体的功能。