神经肽Y对大脑皮质神经元的保护

SICENCE新闻发布作者：李琦军稿号：NRR-238-13神经肽Y对大脑皮质神经元的保护神经肽Y具有保护神经元的作用，但其是否通过调节小胶质细胞的免疫活性和减少细胞因子等途径尚不明晰？中国河北医科大学赵文清教授所带领的团队研究证实，神经肽Y可以降低过度激活的小胶质细胞免疫活性，避免过量生成白细胞介素1β和肿瘤坏死因子α，降低了大鼠大脑皮质神经元N-甲基-D-天冬氨酸电流密度，从而抑制皮质神经元过度兴奋，起到保护神经元的作用。相关文献发表于《中国神经再生研究（英文版）》杂志2014年5月第9期。免疫组化染色结果显示，原代培养的神经元具有轴突和长的树突，并表达微管相关蛋白2（箭头）Article:NeuropeptideYprotectscerebralcorticalneuronsbyregulatingmicroglialimmunefunction,byQijunLi1,ChangzhengDong2,WenlingLi2,WeiBu3,JiangWu2,WenqingZhao1,2(1GraduateSchool,HebeiMedicalUniversity,Shijiazhuang,HebeiProvince,China;2DepartmentofFunctionalNeurosurgery,HebeiGeneralHospital,Shijiazhuang,HebeiProvince,China;3DepartmentofNeurosurgery,ThirdHospital,HebeiMedicalUniversity,Shijiazhuang,HebeiProvince,China)LiQJ,DongCZ,LiWL,BuW,WuJ,ZhaoWQ.NeuropeptideYprotectscerebralcorticalneuronsbyregulatingmicroglialimmunefunction.NeuralRegenRes.2014;9(9):959-967.欲获更多资讯：NeuralRegenResSICENCE新闻发布作者：李琦军稿号：NRR-238-13NeuropeptideYprotectscerebralcorticalneuronsNeuropeptideYexhibitsneuroprotectiveeffects.Whethertheneuroprotectiveeffectsaremediatedbythepathwaysincludingregulatingtheimmunologicalactivityofreactivemicrogliaandreducingcytokinesremainsunclear.Prof.WenqingZhao,GraduateSchool,HeibeiMedicalUniversity,ChinaandhisteamconfirmedthatneuropeptideYpreventedexcessiveproductionofinterleukin-1βandtumornecrosisfactor-αbyinhibitingmicroglialreactivity,reducedN-methyl-D-aspartatecurrentinratcorticalneurons,preventingexcitotoxicity,andtherebyprotectingneurons.RelatedresultswerepublishedinNeuralRegenerationResearch(Vol.9,No.9,2014).Immunohistochemicalstainingrevealsthatprimaryculturedneuronsextendedaxonsandlongdendritesandexpressedmicrotubule-associatedprotein2(arrow).Article:NeuropeptideYprotectscerebralcorticalneuronsbyregulatingmicroglialimmunefunction,byQijunLi1,ChangzhengDong2,WenlingLi2,WeiBu3,JiangWu2,WenqingZhao1,2(1GraduateSchool,HebeiMedicalUniversity,Shijiazhuang,HebeiProvince,China;2DepartmentofFunctionalNeurosurgery,HebeiGeneralHospital,Shijiazhuang,HebeiProvince,China;3DepartmentofNeurosurgery,ThirdHospital,HebeiMedicalUniversity,Shijiazhuang,HebeiProvince,China)LiQJ,DongCZ,LiWL,BuW,WuJ,ZhaoWQ.NeuropeptideYprotectscerebralcorticalneuronsbyregulatingmicroglialimmunefunction.NeuralRegenRes.2014;9(9):959-967.