有机硝酸酯类药物的临床应用

235BU;5000IU,2,10:160mg+250ml,,110.1g,1,40mg,3,20mg,1,1.3TIACT(FG)(CT)(BT)(PT)(TT)(KPTT)(PLT)(WBC)1.42t22.124TIA64.7%20.6%,3TIA88.2%58.6%,(P0.01)3(9%),562.2(P0.05),TTKPTT3DF2521243TIA(P0.01)TIA,368.97%,(P0.01)DF2521TIA,DF2521,,,,(t2PA),,22PIPAI,,,,,,,:aVaIXaXa,,,,;Xa,;t2PA,,;,,,,BTCTPT,TTKPTT,CT,,(),:2004-12-13;:2005-04-301,1,2(1.,250022;2.,250021):R972.1:A:1008-1089(2005)09-0035-03191980,,,,2070,1974(ISDN)22(22ISMN)52(52ISMN),52ISMN12050,2060,,,,,,70(AMI),AMIAMI,ISDN,532005339(547)0.5,52ISMN22ISMN,ISMN(5),ISDN,,ISMN,24872,,,(48),,2.1,,,(CA),(AVP)--(RAAS),,,2.2(NO)(-SH),-SH,NO,NO,2.3(NG)NO,[1],(O-),,(NOS)[2],NG,NONO;O-O-NO,NO,,,O-[3]2.4,72,2.5,,NOS[4],33.1(812),,3.2,,,,N2(NAC)L23.3(ACEI)(ARB)RAAS,ACEI,,ACEI-SH,RAAS2C,ARB3.4ECE[5],,3.52,(SNS)RAAS,,3.6,,,3.7,30mg/d,[6]44.1:,,;,63(548)2005339,,,[7];,,[8]4.2,,;,,,,4.3,,,48,,[9]4.4,,[10]4.54.6,[11]55.1,,,5.2;5.3:,,,5.4:8,,,,1,5.5:66.13:NGISDN52ISMN,,[12]52ISMN,,,,,NGISDN52ISMN,,,6.26.2.1NG,,80%6.2.2NGISDN6.2.3ISMN,,100%,45,2,1,NG30%,ISDN20%30%,306.2.4NGISDN,6.2.5NGISDN:[1]BoesgaardS,AldershvileJ,PoulsenHE,etal.Nitratetoleranceinvivoisnotassociatedwithdepletionofarterialorvenousthiollevels[J].CircRes,1994,74115-120.[2]HofmannH,SchmidHH.Thioldependenceofnitricoxidesyn2thase[J].Biochemistry,1995,3413443-13452.[3]ParkerJD,FarrellB,FentonT,etal.Effectsofdiuretictherapyonthedevelopmentoftoleranceduringcontinuoustherapywithni2troglycerin[J].JAmCollCardiol,1992,20616-622.[4]GruhnN,AldershvileJ,BoesgaardS,etal.Tetrahydrobiopterinimprovesendotheliumdependentvasodilationinnitroglycerintoler2antrate[J].EurJPharmacol,2001,416245-249.[5]WatarabeH,KakihanaM,ChtsukaS,etal.ThepreventiveeffectofvitarninEonnitratetolerance[J].Circulation,1996,94(8)501-502.[6],,.[J].,2003,5(4)546.[7]PiekJJ,venLiebergenPA,KochKT,etal.Pharmacologicalmodulationofthehumancollateralvascularresistanceinacuteandchroniccoronaryocclusionassessedbyin2tracoronarybloodflowvelocityanalysisinangioplastymodel[J].Circulation,1997,96106-115.[8].[J].,2002,30(3)187.[9],,.[J].,2004,12(4)492.[10]...,2004,31(1)23[11]TakahasviH,NukiwaT,BassetP,etal.MyelomonocyticcallLineageexpressionofneutrophilelastasegeng[J].JBiolChem,1998,2632543-2547.[12].[J].,2002,22(8)458.:2004-12-20;:2005-06-30732005339(549)