多发性单神经病

multiplemononeuropathy1.NeurolNeuroimmunolNeuroinflamm.2015Nov12;3(1):e180.doi:10.1212/NXI.0000000000000180.eCollection2016.Vasculiticneuropathyfollowingexposuretominocycline.BarattaJM(1),DyckPJ(1),BrandP(1),ThaisetthawatkulP(1),DyckPJ(1),EngelstadJK(1),GoodmanB(1),KaramC(1).Authorinformation:(1)DepartmentsofPhysicalMedicine&Rehabilitation(J.M.B.)andNeurology(C.K.),TheUniversityofNorthCarolina,ChapelHill;theDepartmentofNeurology(P.J.B.D.,P.B.,P.J.D.,J.K.E.),MayoClinic,Rochester,MN;theDepartmentofNeurologicalSciences(P.T.),UniversityofNebraskaMedicalCenter,Omaha;andtheDepartmentofNeurology(B.G.),MayoClinic,Scottsdale,AZ.OBJECTIVE:Toreport3patientswithminocycline-inducedautoimmunityresultinginperipheralnervevasculitis.METHODS:Wereport3patientswho,duringminocyclinetreatmentforacnevulgaris,developedsubacuteonsetofpainandweaknesscausedbyvasculitisinsingleandmultiplemononeuropathypatterns.RESULTS:Eachpatientunderwenteitheranerveormusclebiopsythatconfirmedvasculitis.Onepatientadditionallydevelopedsystemicsymptoms(includingfever,fatigue,andnightsweats)andanotherhadaposteriorcirculationstroke.Symptomsdevelopedwitheitherearlyorprolongeduseofminocycline.Despitewithdrawalofminocycline,patientsneededlong-termimmunotherapytogainneurologicimprovement.CONCLUSIONS:Ourfindingssuggestthatthetypicalneuropathyassociatedwithminocyclineuseispainfulsingleormultiplemononeuropathyduetoperipheralnervevasculitis,whichmayalsobeaccompaniedbypresumedCNSvasculitis(presentingasstroke).PMCID:PMC4645168PMID:26601119[PubMed]2.JAMANeurol.2015Dec1;72(12):1510-8.doi:10.1001/jamaneurol.2015.2347.TheImportanceofRareSubtypesinDiagnosisandTreatmentofPeripheralNeuropathy:AReview.CallaghanBC(1),PriceRS(2),ChenKS(3),FeldmanEL(1).Authorinformation:(1)DepartmentofNeurology,UniversityofMichigan,AnnArbor.(2)DepartmentofNeurology,UniversityofPennsylvania,Philadelphia.(3)DepartmentofNeurosurgery,UniversityofMichigan,AnnArbor.IMPORTANCE:Peripheralneuropathyisaprevalentconditionthatusuallywarrantsathoroughhistoryandexaminationbuthaslimiteddiagnosticevaluation.However,rarelocalizationsofperipheralneuropathyoftenrequiremoreextensivediagnostictestinganddifferenttreatments.OBJECTIVE:Todescriberarelocalizationsofperipheralneuropathy,includingtheappropriatediagnosticevaluationandavailabletreatments.EVIDENCEREVIEW:ReferenceswereidentifiedfromPubMedsearchesconductedonMay29,2015,withanemphasisonsystematicreviewsandrandomizedclinicaltrials.Articleswerealsoidentifiedthroughtheuseoftheauthors'ownfiles.Searchtermsincludedcommonrareneuropathylocalizationsandtheircauses,aswellasepidemiology,pathophysiology,diagnosis,andtreatment.FINDINGS:Diffuse,nonlength-dependentneuropathies,multiplemononeuropathies,polyradiculopathies,plexopathies,andradiculoplexusneuropathiesarerareperipheralneuropathylocalizationsthatoftenrequireextensivediagnostictesting.Atypicalneuropathyfeatures,suchasacute/subacuteonset,asymmetry,and/ormotorpredominantsigns,arefrequentlypresent.Themostcommondiffuse,nonlength-dependentneuropathiesareGuillain-Barrésyndrome,chronicinflammatorydemyelinatingpolyneuropathy,multifocalmotorneuropathy,andamyotrophiclateralsclerosis.Effectivedisease-modifyingtherapiesexistformanydiffuse,nonlength-dependentneuropathiesincludingGuillain-Barrésyndrome,chronicinflammatorydemyelinatingpolyneuropathy,multifocalmotorneuropathy,andsomeparaprotein-associateddemyelinatingneuropathies.Vasculiticneuropathy(multiplemononeuropathy)alsohasefficacioustreatmentoptions,butdefinitiveevidenceofatreatmenteffectforIgManti-MAGneuropathyanddiabeticamyotrophy(radiculoplexusneuropathy)islacking.CONCLUSIONSANDRELEVANCE:Recognitionofrarelocalizationsofperipheralneuropathyisessentialgiventheimplicationsfordiagnostictestingandtreatment.Electrodiagnosticstudiesareanimportantearlystepinthediagnosticevaluationandprovideinformationonthelocalizationandpathophysiologyofnerveinjury.PMID:26437251[PubMed-inprocess]3.AnnRehabilMed.2015Oct;39(5):833-7.doi:10.5535/arm.2015.39.5.833.Epub2015Oct26.MultipleLowerExtremityMononeuropathiesbySegmentalSchwannomatosis:ACaseReport.KwonNY(1),OhHM(1),KoYJ(1).Authorinformation:(1)DepartmentofRehabilitationMedicine,CollegeofMedicine,TheCatholicUniversityofKorea,Seoul,Korea.Schwannomaisanencapsulatednervesheathtumorthatisdistinctfromneurofibromatosis.Itisdefinedastheoccurrenceofmultipleschwannomaswithoutanybilateralvestibularschwannomas.A46-year-oldmanwithmultipleschwannomasinvolvingperipheralnervesoftheipsilaterallowerextremitypresentedwithneurologicsymptoms.Electrodiagnosticstudiesrevealedmultiplemononeuropathiesinvolvingtheleftsciatic,commonperoneal,tibial,femoralandsuperiorglutealnerves.Histologicfindingsconfirmedthediagnosisofschwannoma.Wereportedthisrarecaseofsegmentalschwannomatosisthatpresentedwithneurologicsymptomsincludingmotorweakness,whichwasconfirmedasmultiplemononeuropathiesbyelectrodiagnosticstudies.PMCID:PMC4654091PMID:26605183[PubMed]4.MuscleNerve.2015Jul;52(1):151-2.doi:10.1002/mus.24617.Brachioplasty-associatedmultiplemononeuropathies.ThawaniSP(1),BieriP(2),Hersk