基质金属蛋白酶9可成为颅内外动脉支架置入后发生再狭窄的干预靶标

SICENCE新闻发布作者：刘君鹏稿号：NRR_334_14基质金属蛋白酶9可成为颅内外动脉支架置入后发生再狭窄的干预靶标来自中国福建医科大学省立临床学院刘君鹏所在研究团队发现，颅内外动脉血管内支架置入后3d基质金属蛋白酶9＞正常参考值2.5倍，可能作为预测和干预再狭窄发生，早期进行神经保护的有效指标。颅内外动脉血管内支架置入是有效安全降低发生缺血性卒中风险的方法，已在全世界广泛的应用。但支架置入后支架内发生的再狭窄是影响疗效的一个重要因素。在动脉支架再狭窄部位，基质金属蛋白酶特别是基质金属蛋白酶9的活性和表达显著提高，调节细胞外基质的降解和沉积，有利于血管壁平滑肌细胞从中膜向内膜迁移并进行增殖，进而再次发生动脉狭窄。刘君鹏所在研究团队发现，接受颅内外动脉支架置入3d后，患者血清基质金属蛋白酶9水平＞正常参考值2.5倍时，有30%的患者出现再狭窄。作者认为这一指标可作为预测颅内外动脉血管内支架置入后再狭窄以及此时需实施干预性神经保护措施的有效指标。相关文献发表于《中国神经再生研究（英文版）》杂志2015年4月第4期。颅内外动脉血管内支架置入1年后患者又出现再狭窄Article:Matrixmetalloproteinase9levelasanindicatorforrestenosisfollowingcervicalandintracranialangioplastyandstenting,byJun-pengLiu,Yin-zhouWang,Yong-kunLi,QiongCheng,ZhengZheng(DepartmentofNeurology,FujianProvincialHospital,ProvincialClinicalDepartmentofFujianMedicalUniversity,Fuzhou,FujianProvince,China)LiuJP,WangYZ,LiYK,ChengQ,ZhengZ(2015)Matrixmetalloproteinase9levelasanindicatorforrestenosisfollowingcervicalandintracranialangioplastyandstenting.NeuralRegenRes10(4):631-635.欲获更多资讯：NeuralRegenResMMP-9levelreflectsrestenosisaftercervicalandintracranialangioplastyandstentingSICENCE新闻发布作者：刘君鹏稿号：NRR_334_14ArecentstudybyateamofscientistsledbyJun-pengLiu,ClinicalCollegeofFujianMedicalUniversity,Chinafoundthatwhentheserumlevelofmatrixmetalloproteinase9(MMP-9)is2.5timeshigherthanpreoperationallevelat3daysaftercervicalandintra-cranialangioplastyandstenting,itmayserveasapredictorofin-stentrestenosis.Cervicalandintracranialangioplastyandstentingisaneffectiveandsafemethodofreducingtheriskofischemicstroke,butitmaybeaffectedbyin-stentrestenosis.ArecentstudyhasfoundthatMMPs,especiallyMMP-9,arehighlyactiveandexpressedatthesiteofarteryin-stentrestenosis.MMP-9regulatesthedegradationanddepositionofextracellularmatrixandpromotessmoothmusclecellmigrationinvesselwallsfromthemediatotheintima,therebycontributingtoarteryrestenosis.Jun-pengLiuetal.foundthatrestenosisoccurredin30%ofpatientswhentheserumlevelofMMP-93daysaftersurgerywas2.5timeshigherthanpreoperativelevels.Theyconsideredthatthisindexcanbeusedasaneffectiveindicatorforrestenosisfollowingcervicalandintracranialangioplastyandstenting.NeuralRegenerationResearchhasrecentlyreportedthisdiscovery.Restenosisoccurred1yearaftercervicalandintracranialangioplastyandstenting.Article:Matrixmetalloproteinase9levelasanindicatorforrestenosisfollowingcervicalandintracranialangioplastyandstenting,byJun-pengLiu,Yin-zhouWang,Yong-kunLi,QiongCheng,ZhengZheng(DepartmentofNeurology,FujianProvincialHospital,ProvincialClinicalDepartmentofFujianMedicalUniversity,Fuzhou,FujianProvince,China)LiuJP,WangYZ,LiYK,ChengQ,ZhengZ(2015)Matrixmetalloproteinase9levelasanindicatorforrestenosisfollowingcervicalandintracranialangioplastyandstenting.NeuralRegenRes10(4):631-635.