周围神经修复的组织学评价应是完整且合适的

NRR-D-14-00215VíctorCarriel新闻周围神经修复的组织学评价：应是完整且合适的由西班牙的格拉纳达大学和比利时的根特大学研究人员共同撰写了一个关于周围神经再生中组织学评估的综述。在此综述中，作者概述了组织学在准确评估周围神经修复的作用及正确评估的重要性。作者对现有的周围神经再生检测中应用的组织学分析手段进行了优缺点的总结。作者认为，组织化学方法是一个可接受的特异性评估总体参数的方法，而免疫组织化学技术可以执行高度精确的分析，电子投射显微镜是一个合适的演示神经再生亚细胞变化的方法。在综述中，作者概述了关于组织化学、免疫组织化学和超微组织结构的定量和统计分析的有效性。并认为选取一个合适且完整的组织学分析方法并结合临床和功能分析来显示复杂的神经再生过程是很必要的。Article:HistologicalassessmentinperipheralnervetissueengineeringVíctorCarriel1,2,IngridGarzón1,MiguelAlaminos1,MariaCornelissen1,2(1DepartmentofHistology(TissueEngineeringGroup),FacultyofMedicine,UniversityofGranada,andInstitutodeInvestigaciónBiosanitariaibs.Granada,Spain2DepartmentofBasicMedicalSciences(HistologyandTissueEngineeringGroup),FacultyofMedicine,GhentUniversity,Ghent,Belgium)CarrielV,GarzónI,AlaminosM,CornelissenM.Histologicalassessmentinperipheralnervetissueengineering.NeuralRegenRes.2014;9(18):1657-1660.欲获更多资讯：文章全文请见：NeuralRegenRes.TheimportanceofthehistologicalassessmentinperipheralnervetissueengineeringSUMMARYPromoteanefficientperipheralnerveregenerationisoneofthecurrentgoalsofthetissueengineering.Inordertodemonstratethesuccessofthenerveregenerationitisnecessarytoevaluatethisprocesswithanadequatepanelofclinical,functionalandhistologicaltechniques.Thehistologicalanalysisprovidesobjectivesandreliableresults,makingthesetechniquesoneofthemostvaluablestoolstoconfirmthesuccessofthenerveregenerationwithintheclinicalandfunctionalanalysis.NEWSRELEASENRR-D-14-00215VíctorCarriel新闻ResearchersfromthetissueengineeringgroupatboththeUniversityofGranadainSpainandGhentUniversityinBelgiumperformedabriefreviewaboutthecurrenthistologicalassessmentoftheperipheralnerveregenerationintissueengineering.Inthisreviewtheauthorsgiveageneraloverviewandtheaimofthetissueengineeringinperipheralnerverepairandtheimportanceofthecorrectassessmentofthenerveregenerationhighlightingthevalueofthehistologicalanalysis.Regardingtothehistologicalanalysistheauthorsclassifiedthesetechniquesanddiscussedabouttheiradvantages,limitationsandadequateapplicationinnerveregeneration.Thehistochemicaltechniquesofferthepossibilitytoevaluatedgeneralparameterswithanacceptablespecificity,whiletheimmunohistochemicaltechniquesallowperformingahighlyspecificanalysis.Inthecaseofthetransmissionelectronmicroscopy,itisasuitablemethodtodemonstratesubcellularchangesduringnerveregeneration.Inthisreview,theauthorsgiveanoverviewabouttheusefulnessoftheapplicationofquantitativeandstatisticalanalysistohistochemical,immunohistochemicalandultrastructuraltechniques.Thereview,reportedonNeuralRegenerationResearch(Vol.9,No.18,2014),showedtheimportanceofthehistologicalanalysisinperipheralnervetissueengineering.Theauthorsconcludedthatitisnecessarytocombinetheclinicalandfunctionalanalysiswithanadequateandcompletehistologicalanalysisofthecomplexprocessofperipheralnerveregeneration.Article:HistologicalassessmentinperipheralnervetissueengineeringVíctorCarriel1,2,IngridGarzón1,MiguelAlaminos1,MariaCornelissen1,2(1DepartmentofHistology(TissueEngineeringGroup),FacultyofMedicine,UniversityofGranada,andInstitutodeInvestigaciónBiosanitariaibs.Granada,Spain2DepartmentofBasicMedicalSciences(HistologyandTissueEngineeringGroup),FacultyofMedicine,GhentUniversity,Ghent,Belgium)CarrielV,GarzónI,AlaminosM,CornelissenM.Histologicalassessmentinperipheralnervetissueengineering.NeuralRegenRes.2014;9(18):1657-1660.