细菌生物膜的研究进展

:100083:(E2mail:[e-mail])(),,(biofilm,BF),(planktonic)BF,BFBF,,BF1,2,BF,,,,BF2030,Gib2bonsvanHoute2BF,BF,BF,BF,,,()BF,BF,,,65%BF325BF,207090,BF,BF1990,,(NIH)3,4,BF,BF,BF(BF),,1,2,6BF97%,BF,BFDNARNABF,BF,BF():BF7(adhesin)(receptor),,,,,,,,(Actinomycesnaeslundii),18,BF,,,()BF:,,(ex2opolysaccharide,EPS)EPS,(microcolony)BF,,EPSBF1,6,EPS,,34320025223ChinJMicrobiolImmunol,May2002,Vol22,No.3,BF()BF:BF,(confocalscanninglasermi2croscope,CSLM)BF,(heterogeneity),,,9,BF,BFBF,EPS,(quorumsensingsystem)10,(Pseudomonasaeruginosa),,BF,,,BF,N2(N2acylhomoserinelactones,AHL),AHL,AHL,,AHL10BF,,BFBF,,,BF,BFRNApH,,BF,9,BF,,BF,,BF,,BF,()BF,BFBF,pH,BF,BF,(Escherichiacoli)K212(Vibriocholerae)BF,,O517H7BF,BF,BF,,BF,,BFBF,BF,,BF11,(Streptococcus)BF,,,(Fusobacteri2um)(coaggregation),(pH),,,,,BF():,BF101000BF12,13:(1)BFEPS,,;(2)BF,,,,,BFBF,;(3),BFBF,;(4)BF,244320025223ChinJMicrobiolImmunol,May2002,Vol22,No.3():BF14217:(1)(cy2tokine),(Staphylococcusepidermidis)BF816;(2);(3)BF;(4)BF,BF,BF,;(5)BF,BF,,BF,,BF()BF,BF,,BF,181999Schneewind19(S.aureus)(sor2tase),,20,,,EPS,EPSAHL,EPSAHL,BF,,()BF,,BF,,BF,,,4,:(probiotics),;(prebiotics),;(synbiotics),21(),BFBF22,23;(Candi2da)24(),BF,Yamasaki25BF,BFBF,BF,BF,BF26,,,BF,BF,,,,BF,,BF;BF;BF,BF,1CostertonJW,LewandowskiZ,CaldwellDE,etal.Microbialbiofilms.An2nuRevMicrobiol,1995,49:7112745.2CostertonJW.Introductiontobiofilm.IntJAntimicrobAgents,1999,11:2172221.3CostertonJW,StewartPS,GreenbergEP.Bacterialbiofilms:acommoncauseofpersistentinfections.Science,1999,284:131821322.4PoteraC.Forgingalinkbetweenbiofilmsanddisease.Science,1999,283:183721839.5ChicurelM.Bacterialbiofilmsandinfections2slimebusters.Nature,2000,54320025223ChinJMicrobiolImmunol,May2002,Vol22,No.3408:2842286.6SutherlandIW.Thebiofilmmatrix2animmobilizedbutdynamicmicrobialenvironment.TrendsMicrobiol,2001,9:2222227.7FinlayBB,FalkowS.Commonthemesinmicrobialpathogenicityrevisited.MicrobiolMolBiolRev,1997,61:1362169.8LiT,JohanssonI,HayD,etal.StrainsofActinomycesnaeslundiiandActinomycesviscosusexhibitstructuralvariantfimbrialsubunitproteinsandbindtodifferentpeptidemotifsinsalivaryproteins.InfectImmun,1999,67:205322059.9WimpennyJ,ManzW,SzewzykU.Heterogeneityinbiofilms.FEMSMicro2biolRev,2000,24:6612671.10DeKievitTR,IglewskiBH.Quorumsensing,geneexpression,andPseu2domonasbiofilms.MethodsEnzymol,1999,310:1172128.11KolenbranderPE.Oralmicrobialcommunities:biofilms,interactions,andgeneticsystems.AnnuRevMicrobiol,2000,54:4132437.12MahT2FC,OTooleGA.Mechanismsofbiofilmresistancetoantimicrobialagents.TrendsMicrobiol,2001,9:34239.13StewartPS,CostertonJW.Antibioticresistanceofbacteriainbiofilms.Lancet,2001,358:1352138.14PedersenSS.Lunginfectionwithalginate2producing,mucoidPseudomonasaeruginosaincysticfibrosis.APMISSuppl,1992,28:1279.15DasguptaMK.Biofilmcausesdecreasedproductionofinterferon2gamma.JAmSocNephrol,1996,7:8772882.16FletcherJ,NairS,PooleS,etal.CytokinedegradationbybiofilmsofPor2phyromonasgingivalis.CurrMicrobiol,1998,36:2162219.17ShiauAL,WuCL.TheinhibitoryeffectofStaphylococcusepidermidisslimeonthephagocytosisofmurineperitonealmacrophagesisinterferon2indepen2dent.MicrobiolImmunol,1998,42:33240.18CostertonJW,StewartPS.Battlingbiofilms.SciAm,2001,258:74281.19MazmanianSK,LiuG,JensenER,etal.Staphylococcusaureussortasemutantsdefectiveinthedisplayofsurfaceproteinsandinthepathogenesisofanimalinfections.ProcNatlAcadSciUSA,2000,97:551025515.20PallenM,LamA,AntonioM,etal.Anembarrassmentofsortases2arich2nessofsubstrates?TrendsMicrobiol,2001,9:972101.21CollinsMD,GibsonGR.Probiotics,prebiotics,andsynbiotics:approachesformodulatingthemicrobialecologyofthegut.AmJClinNutr,1999,69:1052S21057S.22LiedbergH,LundebergT.Silvercoatingofurinarycatheterspreventsadher2enceandgrowthofPseudomonasaeruginosa.UrolRes,1989,17:3572358.23KluehU,WagnerV,KellyS,etal.Efficacyofsilver2coatedfabrictopre2ventbacterialcolonizationandsubsequentdevice2basedbiofilmformation.JBiomedMaterRes,2000,53:6212631.24Arweiler2HarbeckD,SandersA,HeldM,etal.Doesmetalcoatingim2provethedurabilityofsiliconevoiceprostheses?ActaOtolaryngol,2001,121:6432646.25YamasakiO,AkiyamaH,ToiY,etal.AcombinationofroxithromycinandimipenemasanantimicrobialstrategyagainstbiofilmsformedbyStaphylo2coccusaureus.JAntimicrobChemother,2001,48:5732577.26,,,..,1999,79:7572760.(:2001211205)20021981,:,()(CA)(BA)(EM)Medline:,16,96,11100,11,(),(,:100024,:010265756595E2mail:[e-mail]):2255:BM50764320025223ChinJMicrobiolImmunol,May2002,Vol22,No.3