生物信息学及其相关数据库检索

••••NCBI(Bioinformatics)RNARNADNA•••1.2.(-DNA)3.4.5.6.1•GenBankNucleotideSequencedatabase(NCBI)*•EMBLNucleotidesequencedatabase(EBI)*•DDBJ-DNADataBankofJapan*•BIOSINO•dbEST-DatabaseofExpressedSequenceTags(NCBI)•dbSTS-DatabaseofSequenceTaggedSites(NCBI)•NDB-NucleicAcidDatabank(3Dstructures)•BNASDB-NucleicacidstructuredbfromUniversityofPune•SWISS-PROT-proteinsequence•PIR-ProteinInformationResource•PDB-ProteinDataBank[MirrorsinEBI]•SCOP-StructuralClassificationofProteins•CATH-ClassArchitectureTopologyHomology•GDB•MDB•DICTYDBDictyosteliumdiscoideum•EcoGeneEscherichiacoliK12•FLYBASEDrosophila•MAIZEDB•SGDSaccharomyces•STYGENESalmonellatyphimuriumLT2•SUBTILISTBacillussubtilis168•WORMPEPCaenorhabditiselegans•BLAST•PRIMER3•HMGD-HumanGeneMutationdb•dbSNP-Humansinglenucleotidepolymorphism(SNP)db•PAHdb-Humanphenylalaninehydroxylase(PAH)mutationdb•AsthmaandAllergygenedb•BIOMDB-Dbofmutationscausingtetrahydrobiopterindeficiencies•ClustersofOrthologousGroups(COG)-Phylogeneticclassificationofproteinsfrom21completegenomes•XREFdb-Cross-referencingofmodelorganismgeneticswithmammalianphenotypes•TreeBASE-Relationaldbofphylogeneticinformation•TheTreeoflife-Collectionof•Bioinformatics()1985•BioInformer()1997•GenomeResearch()(CSHLPress)1995•JournalofBiomedicalInformatics•NucleicAcidResearch()1973•2000•DBCat19975001.NCBI(TheNationalCenterBiotechnologyInformation)2.EBI(TheEuropeanBioinformationIntitute)3.ExPASy(ExpertProteinAnalysisSystem)4.BioSino5.CBINCBIGenBankElectronicPCRClustersoforthologousgroupsGeneexpressionomnibus(GEO)dbMHCMalariagenetics&genomicsMapViewerHumangenomeresourcesORFfinderRatgenomeresourcesReferencesequenceprojectMousegenomeresourcesRetrovirusresourcesSAGEmapSKY/CGHdatabaseVecScreenNCI-CGAPEntrez•GenBankNCBINCBI199210GenBankGenBankDDBJDNADataBankJapanEMBLEuropeanMolecularBiologyLaboratory200461514000403553170026%ESTs20%GenBankLOCUSIdentifierACCESSIONAccessionnumberDEFINITIONDescriptionKEYWORDSKeywordsSOURCEOrganism(species)ORGANISMOrganism(classification)REFERENCEReferencenumberAUTHORSReferenceauthorsTITLEReferencetitleJOURNALReferencelocationCOMMENTSDatabasecross-referenceMEDLINEMedlinenumberMEDLINEFEATURESFeaturetableheaderdataBASECOUNTORIGIN//Terminationline•••••••BLAST(BasicLocalAlignmentsTool)5BLASTNBLASTPBLASTXTBLASTNTBLASTX•Bit•EECKLF(chemokine-likefactor)CKLF2(1)EntrezCKLF2mRNA(2)BLAST(3)TaxonomySARS(PAH)PAHPAHPAH()PAH1.HCCA2mRNABLAST2.PDCD5