紫草次生代谢物生物学活性研究进展

*650224、、、、。S567．9A0517－6611201028－15592－02ResearchProgressontheBiologicalActivitiesofBoraginaceaeSecondaryMetabolitesHUANGWen-huetalFacultyofLifeScienceandTechnologyKunmingUniversityofScienceandTechnologyKunmingYunnan650224AbstractFromtheaspectsofanti-tumoranti-inflammatoryanti-microbeanti-oxidationanti-fertilityandsoonnewprogressesanddis-coveriesofsomebiologicalactivitiesofBoraginaceaesecondarymetabolitesweresummarized．AndthefutureresearchanddevelopmentofBor-aginaceaesecondarymetaboliteswerepredicted．KeywordsBoraginaceaeBiologicalactivitySecondarymetabolitesAnti-tumorShikonin2009ZC046M07C40780。1985－。*[e-mail]．。2010-07-08、、、、、、、、1。2005《》Boraginaceae2ArnebiaForsk．ArnebiaeuchromaRoyleJohnst．ArnebiaguttataBge．。2LithospermumLinn．LithospermumerythrorhizonSieb．etZucc．OnosmaLinn．OnosmapaniculatumBur．etFranch．2。、、3－4。。。1、、、、、。、、shikoninalkanin、isobutvaleryl-shikonin、acetylshikonin、deoxyshikoonin、β-β-hydroxyo-sovalerylshkonin、isobutyryl-shikonin、ββ-ββ-dim-ethyacrylshikonin、58--14-58-dihydroxy-14-naphthoquinone、58-O-58-O-dimethylacetylshikonin、teracrylshikonin、methyl-acr-ylshikonin。、4-hydroxy-3-methoxycinnamicacid4-hydroxy-3-me-thoxybenzoicacid5－9。22．1。1011。K56212。NF-zBp509。SGC-790113。14。sun-rivin、Bcl-2JAR/MTXMTX15。2．2、PGE216。3－4。UVB1718。RAW264．7NONO5。TlThlT-betIFN-γBIL-1、TNF-α、IL-12MMPs、、E219。CIAThl20。2．3、JournalofAnhuiAgri．Sci．2010382815592－1559316074、、、、、21。、、7。22。HPV23。HPVCA24。2．46SSOD。。。TBHQTB-HQ25。11--2DPPH·β-/26。2．5。27。SD28。－－HPGA－29。FSHLH。HCG30。2．6。。4、、3-－58-O-6。31。2．7AEJ-IAEJ-II2D-D-GalND-Ga1NALT、AST、MDASOD、GSH-PxCCl4。、32－33。2．82．8．1。PtdIns-345-P3BPKB34。2．8．2。、β-3A--1hA-CAT-1A--2hA-CAT-2。IC50120.057．5μmol/L35。A-、β-。2．8．3。。。3020～3036。SPT37。2．8．4。AEJ-I、AEJ-II。38。3。。、、、。。。1．2005M．2005238－239．2．J．20033496－10．3KUNDAKOVICTFOKIALAKISNDOBRICSetal．Evaluationofthean-ti-inflammatoryandcytotoxicactivitiesofnaphthazarinederivativesfromOnosmaleptanthaJ．Phytomedicine200613290－294．4ALEVTESRAKAZLEMBetal．Evaluationofanti-inflammatoryandantinociceptiveactivitiesofsomeOnosmaL．speciesgrowinginTurkeyJ．JournalofEthnopharmacology2008120378－381．5CHENGYWCHANGCYLINKLetal．ShikoninderivativesinhibitedLPS-inducedNOSinRAW264．7cellsviadownregulationofMAPK/NF-kappaBsignalingJ．JournalofEthnopharmacology2008120264－271．160743955138285Fig．5Shortmessageprocessingflow、。1．J．20098106－108．2．STCJ．2009S1420－421．3．ARMJ．20093724檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪11723－11724．155936ELIFCHALISSHULYAAetal．EffectsofOnosmaarmeniacumrootex-tractonethanol-inducedoxidativestressinstomachtissueofratsJ．ChemicoBiologicalInteractions200717040－48．7SHAHINANSAMIAASHEIKHARetal．AntibacterialactivitydirectedisolationofcompoundsfromOnosmahispidumJ．MicrobiologicalRe-search200616143－48．8OZGENUIKBALMHACIMUFTUOGLUAetal．Fibroblastgrowthstim-ulationbyextractsandcompoundsofOnosmaargentatumrootsJ．Jour-nalofEthnopharmacology2006104100－103．9．J．2009243241－243．10．J．20077163727－3728．11．J．200722253585－3587．12．K562J．2009172209－211．13ZENGYLIUGZHOULM．InhibitoryeffectofacetylshikoninonhumangastriccarcinomacelllineSGC-7901invitroandinvivoJ．WorldJGastroenterol200915151816－1820．14XUANYYHUX．Naturallyoccurringshikoninanalogues-Aclassofnec-roptoticinducersthatcircumventcancerdrugresistanceJ．CancerLet-ters2009274233－242．15．JAR/MTXsurvivinBcl-2J．200729191880－1882．16．J．200729191892－1893．17TAKAHIROIIKUYOS．ProtectionofhumankeratinocytesfromUVB-in-ducedinflammationusingrootextractofLithospermumerythrorhizonJ．BiolPharmBull2007305928－934．18KYONGNNSONMSPARKJHetal．ShikoninsattenuatemicroglialinflammatoryresponsesbyinhibitionofERKAktandNF-kBneuropro-tectiveimplicationsJ．Neuropharmacology200855819－825．19MENDOZAL．AnetworkmodelforthecontrolofthedifferentiationprocessinThcellsJ．Biosystems2006842101－14．20．J．200943148－51．21．J．20071892217．22．J．20071971603－1605．23．DNAJ．200629452－54．24．D．2007．25．J．2009301252－254．26．J．2007255490－493．27．J．20073091120－1122．28．J．200833202378－2381．29．J．2008193169－172．30YINZFHUYZSUYH．InfluenceofLithospermumonpregnancyJ．JournalofChineseInteg-rativeMedicine200755494－496．31PEIXWWANGKZBAICYetal．Clinicalexperi-mentalstudyofArnebiarootoilpromotinghistologicalchangeandup-regulatingbFGFex-pressioninthewoundJ．JournalofCollegesofPLA200621155－59．32··．D-J．200631191646－1649．33··．J．20061791676－1678．34KIYOMINKYOKOYTOMOSetal．Anaphthoquinonederivativeshikoninhasinsulin-likeactionsbyinhibitingbothphosphataseandten-sinhomologdeletedonchromosome10andtyrosinephosphatasesJ．MolPharmacol2006701143－1149．35SOJINAYONGDPYOUNGKPetal．HumanACATinhibitoryeffectsofshikoninderivativesfromLithospermumerythrorhizonJ．Bioorganic＆MedicinalChemistryLetters2007171112－1116．36MANJCHUEYCHHSIENCCetal．Cosmeticformulationscontai-ningLithospermumerythrorhizonrootextractshowmoisturizingeffectsonhumanskinJ．ArchDermatolRes2008300317－323．37PHUONGTTKEONWKJEONGKKetal．Lithospermicacidderive-ativesfromLithospermumerythrorhizonincreasedexpressionofserinepalmitoyltransferaseinhumanHaCaTcellsJ．Bioorganic＆MedicinalChemistryLetters2009191815－1817．38·．J．2007303228－229．39KANGJHWUHLYANGJetal．Studyontherelationshipbetwe