92第二节 抗结核药物

234z–––z5z–zzzz6zzz–z7NOHNNH2zzNNONHOOOHOOHOOHOHOHONO89zzNOHNNH2NOHO10zzNOHNNH211zzOHOHOH2N12z–z–NNHSNH2HNOOHNNNHSNH213zzNOHNNH2NNNHSNH21415NHNONH2NNOOHNH2NH2O2,V2O5H2O16zzzzNOHNNH21,42,317z––ONNHNH2OCuNNHH2NONNHNH2Cu18z–z–H2NNH219NOOMNOONH2NHNONHNNNOHH20z––NHNONH2NOOH+HBr+N221zzz22zz–NOOHNOHO23z–z24NHNONH2NHNONH2NOO-NOOPO3HOHOONNNNNH2OPOPOOOOOOHOHO+isonicotinicacidCellWallCellWall25NNONR3R2R1H26NHNONOHOOHOOHONHNONOHNHNONOCaNHNONO27zz–zz28NHNONOOHNHNONH2NHNONOHOOHONHNONHONOO-+NH2NH2H2NNHOHNNHOON-29zz––z–zNHNONHO30zz–zNOO-+NH2NH231zz–zNHNHOOH2NNHO32zzzNSNH2NNONH2OHOONa.H2OH2N3334zzNNONHOOOHOOHOOHOHOHONO35zNNONHOOOHOOHOOHOHOHONO36zzzNNONHOOOHOOHOOHOHOHONO37ONHOOHOHOOHOHHHHOHHHOOHOHOHROOOHOHOHOOO*********38zz–39zzz–ONHOOOHOOHOOHOHOOOOHO123456789101112131921242540zz–––ONHOOOHOOHOOHOHOHOO123456789101112131921242541zz––NNONHOOOHOOHOOHOHOHONO42zONHOOOHOOHOOHOHOHOO1234567891011121319212425NNNONHOOOHOOHOOHOHOHOO1234567891011121319212425NNN43zzNNONHOOOHOOHOOHOHOHONO44z–NNONHOOOHOOHOOHOHOHONO45z–zNNONHOOOHOOHOOHOHOHONO46z––z47zz4849zz–––50zz–zONHOOOHOOHOOHOHOHOON1234567891011121319212425NN51zzzzONHOOOHOOHOOHOHOHOON1234567891011121319212425NN52zz–5354zzzNNONHOOHOHOOHOOHOHOHON123456789101112131921242555z–ONHOOOHOOHOOHOHOHOOO123456789101112131921242556zz––57z–NNONHOOOHOOHOOHOHOHONO5859z–z60z