个体化药物治疗及其基因诊断

:410078,,60%,40%[1],,,617%,0132%,46[2],,70%80%,,,,,,,40,,,,,1/3500,,,,50,,,P450CYP2D6CYP2C19CYP2C9N2(NAT2)(thiopurinemethyltransferase,TPMT),P(P2glycoprotein,PGP)OATP2C52(52HT),,,P450CYP2D6,CYP2D64,7%40%50%3%,CYP2D61%10%,1%2%CYP2D640,,,440%80%120%180%,,[3],CYP2C19,CYP2C9,NAT2,TPMT,72212005122812ChinJLabMed,December2005,Vol28,No112©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[4],5,,,,2185Gb,2025[5]159[6],DNA0101%,,,,,,,1999419,,,2005322,(FDA),(SFDA),,,,,,,,(SNP),,CYP2A66,CYP2D6210SNP,PCR,PCR/RFLPSNP,,,,SNP,,DNAPCR,,,,,,,,,,PCRDNAPCR,,,,,,200412,FDAAmplichipp450RocheAffymetrix,2003,82212005122812ChinJLabMed,December2005,Vol28,No112©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.:2012204.2LazarouJ,PomeranzBH,CoreyPN.Incidenceofadversedrugreactionsinhospitalizedpatients:ameta2analysisofprospectivestudies.JAMA,1998,279:120021205.3KirchheinerJ,FuhrU,BrockmollerJ.Pharmacogenetics2basedtherapeuticrecommendations2readyforclinicalpractice?NatRevDrugDiscov,2005,4:6392647.4MurphyGMJr,HollanderSB,RodriguesHE,etal.Effectsoftheserotonintransportergenepromoterpolymorphismonmirtazapineandparoxetineefficacyandadverseeventsingeriatricmajordepression.ArchGenPsychiatry,2004,61:116321169.5InternationalHumanGenomeSequencingConsortium.Finishingtheeuchromaticsequenceofthehumangenome.Nature,2004,431:9312945.6HindsDA,StuveLL,NilsenG,etal.Whole2genomepatternsofcommonDNAvariationinthreehumanpopulations.Science,2005,307:107221079.(:2005209214)(:),,,,,20068,,11:(),21:(1);(2);(3);(4);(5);(6);(7);(8);(9);(10)31:(1),;(2)::800Word,,A4:41:(1):,;:()[e-mail]()[e-mail];(2)(+,):11,()10004451:200643092212005122812ChinJLabMed,December2005,Vol28,No112©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.