中医方药量_效关系科学问题的探讨

-13,2,1,3,4,1,1,1(1,210046;2,210046;3,300193;4,201203):,,,,(;)----:;;;;;:R289.1:A:1000-5005(2010)01-0001-06AnExplorationintoDose-EffectRelationshipofChineseDrugPrescriptionsDUANJin2ao13,WUMian2hua2,FANXin2sheng1,ZHANGYan2jun3,LIUCheng2hai4,TANGYu2ping1,SHANGEr2xin1,WANGZhong2yue1(1KeyLaboratoryforPrescriptionResearchofJiangsu,NanjingUniversityofChineseMedicine,Nanjing,Jiangsu,210046,China;2FirstClinicalCollegeofNanjingUniversityofChineseMedicine,Nanjing,Jiangsu,210046,China;3PharmacologyCollegeofTianjinUniversityofChineseMedicine,Tianjin,300193,China;4ShanghaiUniversityofChineseMedicine,Shanghai,201203,China)ABSTRACT:Thereisadose-effectrelationshipinChinesedrugprescriptions.Withdifferentcombinationofdrugsintheprescription,thedosageofeachdrugvaries,andthedrugsincombinationsupplementorcounteracteachother.OneofthedifferencesbetweenChinesedrugsandchemicaldrugsisthefactthatChinesemedicinepaysattentiontothesyndromes,whichisalsothebasisforthedose-effectrelationshipinChinesedrugprescriptions.TheeffectofChinesedrugprescriptionsisthemanifestationoftheinteractionbetweencompo2nentsandthehumanbody.Theauthorsputforwardtheviewthatthereexistsdose-effectrelationshipinclassicalprescriptions,i.e.thetwo-phasetwo-periodcharacteristics(theformerreferringtoeffectonsyndromesandeffectondiseases;thelatterreferringtothetwoperiodoftimeofeffectivenesscorrespondingtothetwophases),andthefive-element(disease,structure,dosage,substance,efficacy)correlationregularity.KEYWORDS:Chinesemedicine;drugprescription;dose-effectrelationship;researchmode;basiccharacteristics;two-phasetwo-periodcharacteristics,,-,,,,,,,,-,:2009-10-28;:2009-12-10:(06KJA36022);(2006):(1956-),,,,,3:025-85811116120101261JOURNALOFNANJINGTCMUNIVERSITYVol.26No.1Jan.2010,,-[1]-[2][3],,,,-,1---,,,,,,,,,,,,,,,,,,-109,(/):15;16;18;24;28;0.755;730;14;14[4][4],1133:,;,;,,:,;,,,,-:3200g,11,-3:,,,,,,2,,--,,,[6]:,,,,,,220101261,,[7]5,,,,;,,,,,,,-,,,,;,,-,3--,,,,,,,;:-:,-:,,--,--,,3.1--,,/,---,-2-43.2-,,/,5-7233,:-14--657-3.3,,,,,,,,,Sigmoid,:E=Emax(1-e-t)+(1)E=Emax1+e-kt+t0(2)E,Emax,(1),,(2)Sigmoid,k,t0,,Emax,,:E=d(1-e-dt)+(3)E=d1+e-kt-yd+t0(4)d(1)(2)E2maxd,,(3)(4)td,4-,,-----420101261,,,,,-,------5,,3--,,;--,;--,;--,;--,,,5(1)-,,,,,-,600,,--[8],[9][10][11],,[12](2),--,,--,,,,,,,(3),,-[4,13214],-,[15218],,/,,-,--,--,,/,,-,-,------,:--,,;--5,:-1,;--,;--,;--,6,,,,,,-,,,,--,,/,-,,,/,--,----,,,,,:[1]WangLan,ZhouGB,LiuP,etal.DissectionofmechanismsofChinesemedicinalformulaRealgar2Indigonaturalisasanef2fectivetreatmentforpromyelocyticleukemia[J].PNAS,2008,105(12):4826-4831.[2],.-[J].,2005,3(5):258-261.[3]MuYP,LiuP,DuGL,etal.ActionmechanismofYiGuanJianDecoctiononCCl4inducedcirrhosisinrats[J].J.Ethnopharm,2009,121(1):35-42.[4],,,.[J].,2009,25(1):15-19.[5].[J],,1983,(12):36-38.[6],,,.[J].,2009,25(1):270-274.[7],,.[J].,2009,25(1):5-7.[8],,,.,[J].,2008,33(3):229-232.[9],,,.[J].,1999,6(11):32-34.[10],,.[J].,2006,31(10):829-831.[11],,,.[J].,2008,6(5):377-381.[12],.[J].,2006,23(1):63-64.[13],,,.-[J].,2009,25(1):17-20.[14],,,.[J].,2008,24(6):379-382.[15],,,.[J].,2008,24(2):94-96.[16],,,.-[J].,2009,15(2):64-67.[17],,,.[J].,2009,25(1):50-54.[18]SuSL,HuaYQ,DuanJA,etal.Hypothesisofactivecompo2nentsinvolatileoilfromaChineseherbsformulation,Shao2Fu2Zhu2YuDecoction,usingGC2MSandChemometrics[J].JSepSci,2008,31(6):1085-1091.(:)620101261