中药有效成分提取技术及其应用

:1004-9533(2005)06-0450-06,,(,300072):,,,:;;:TQ46016:AExtractTechniqueofChineseMedicineEfficaciousIngredientandItsApplicationLIZhen,JIALiang,JIAShao2yi(SchoolofChemicalEngineering,TianjinUniversity,Tianjin300072,China)Abstract:TheextractandseparationofefficaciousingredientisaveryimportantstepintheindustryproductionofChinesemedicinepreparation,anditdirectlyrelatewiththequantity,curativeeffectandoutputofChinesemedicinepreparation.InrecentyearsmanyscientistsfocusonthedevelopmentofseparationofChinesemedicineefficaciousingredientcombinewithitscharacteristic.ThispaperdetailyintroducesthenewtechniqueandapplicationofextractandseparationofChinesemedicine.Keywords:Chinesemedicine;efficaciousingredient;separationtechnique,,,,;,;:;;[1],,,,,,,,,,2000,1979,30%[2]:2004-09-21:(1980-),,,,:,:[phone],E2mail:[e-mail]200511Nov.2005CHEMICALINDUSTRYANDENGINEERING226Vol.22No.6©1995-2006TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.1,,,[2]:::[3]111,199019,1945,826,4215%[4],,(),,112,,(),()(),(),,,,[5],,,,,2211(SFE)[6],()(),[1],,,,,,,,[2]SFE[7],,,[8],,[9],[10]212(SBE)[1811],,,SBE,(),pH,,,,,,,,SBEpH;SBE,154226:©1995-2006TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.(SBESBE+)HPLC,SBEM[12]SBE,,,,,213(UF)[1281314]60,,:,(),,,[15]::;;,,;,;,,,,,,,,,(),[16],,,214[12817],70,,,,215[1281819],,,,,,,,,,,:;;;:,[20]216(ME)[28182122],,,,,,,,254200511©1995-2006TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.,,,,,,:,,,,,,,,,,,,,,,,,,[23],,[24]217[6],,,,,,,,,,,,,pH[25]218,5m10m,95%,,,,,,:[26],,219[1],,,,,,2110[1],,2111,,,()([27]),,,,[28]2112,,,,354226:©1995-2006TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.,[29]80,[30]2113(ATPE),,,,,,AlfredATPE[31]3,,,,,,,,,,,,,,,,,,,!:[1],.[J].,2001,24(6):60-62.[2].[J].,2000,25(11):826-828.[3].[M].:,1998.[4].[M].:,1997.[5].[M].:,1999.[6]HAUTHALWH.Advanceswithsupercriticalfluids[J].Chemsphere,2001,43(1):123-127.[7]SMITHRM.Supercriticalfluidsinseparationsciencedream,therealityandthefuture[J].JChormatogrA,1999,856(1):83-85.[8].[J].,2000,15(4):64-67.[9].[J].,2003,17(1):22.[10],.(SFE)[J].,2001,20(1):34-35.[11],,.()[J].,2002,30(4):239-240.[12].[J].,2000,2(1):35-37.[13],,,.[J].,2000,16(1):13-14.[14],.[J].,2002,18(2):183-192.[15],.[J].,1994,16(1):4-16.[16].[J].,2002,18(6):22-24.[17],,.[J].,2001,17(4):379-384.[18],,.[J].,2003,18(12):32-33.[19].[J].,2002,14(3):245-249.[20].[J].,1994,21(6):500-502.[21].[J].,1998,15(1):691-692.[22].[J].,2002,24(4):38-39.[23].[J].,2002,33(1):23-26.[24],,,.[J].,2004,25(1):35-38.[25].[J].,2002,31(2):103-104.454200511©1995-2006TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.[26].[J].,1998,20(2):17-19.[27].[J].,1996,18(12):7-9.[28].[J].,1998,18(1):60-62.[29]CAOX,TIANY,ZHANGTY,etal.Semi2preparativeseparationandpurificationoftaxolanalogsbyhigh2speedcountercurrentchromatography[J].PrepBiotechnol,1998,28(1):79-83.[30].[J].,1998,49(1):92-96.[31]ALFREDPA,TJERNELDF,MODLINRF.Partitioningofecdysteroidsusingtemperature2inducesphaseseparation[J].Chormatogr,1993,628:205-209.554226:©1995-2006TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.