国家发改委医药工业信息中心站上海数图医药科技有限公司

18······················································································································································································································································································································································································································································································································································································1147R&D710182125OMNICEF25FDA272929(200040)021-62473198021-62890581e-mail:[e-mail](valdecoxib)2004Arcoxiaetoricoxib20031230FDAArcoxiaLehmanBrothersArcoxia200442005Arcoxia(CelebrexBextra)RaymondJames&AssociatesArcoxia2EmendaprepitantMK-7672003112006102(NAS)IMS12003NAS3020023616.7%2070IMSNAS197932NAS251NASIMS12003NASNASNAS222003NAS7(targetingdrugdeliverysystemTDDS)8(passivetargetingpreparation)2(activetargetingpreparation)3(Physicalandchemicaltargetingpreparation)6123456319(SolvayPharmaceutical)(10)(Kemstro)1020mgKemstro20mg1.520042(Imitrex)4Imitrex100mg57%,50mg50%266%100mg51%50mg2(432)(1)(313)75%100mg53%50mg2200221620073309%(ADHD)/2003112004131120043FDA(Myfortic),Myfortic()11()70%18700200427212.11313(Zithromax)3714ZithromaxZithromax13Zithromax500mg13(Augmentin/500mg/125mg)310Zithromax500mg1399%82%2.2111000mg(CiproXR)11000mg714CiproXR112(Lupin)1(Ceff-ER750mg)32.41(Biovail)1CardizemLA124120180240300360420540mg/CardizemLA2.51215(Biovail)1FDA(WellbutrinXL)18150300mg/13(ReliantPharmaceuticals)(InnoPranXL)12480120mgInnoPranXL3013(Eurand)Diffucaps2322004/2200810.91//(Caduet)/5mg/10mg5mg/20mg5mg/40mg5mg/80mg10mg/10mg10mg/20mg10mg/40mg10mg/80mg5mg10mgCaduet12()30003700CaduetCaduetCaduet(β)2//(Symbyax)/6mg/25mg6mg/50mg12mg/25mg12mg/50mgSymbyax3(5-)14(Ki=411nmol/L),D1-4(Ki=1131nmol/L),M1-5(Ki=1.925nmol/L),H1(Ki=7nmol/L),α1(Ki=19nmol/L)GABAABZDβ(Ki10µmol/L)5-60mg60mg85mg(16%)-(16%)612mg(25mg)14%3(eprosartan)/(TevetenHCT)22/312634%TevetenHCT1044%FDA(olmesartanmedoxomil)/(BenicarHCT)3/20mg/12.5mg40mg/12.5mg40mg/25mg2414mmHg40.3mg/1.5mg(Prempro)FDAPrempro0.45mg/1.5mg15(aaiPharma)(500mg)100mg(DarvocetA500)5Stalevo3Stalevo(Ranbaxy)(Raniclor)125187250375mg/FDA125187250375mg213027%73%1(ColumbiaLaboratories)(Striant)()()Striant50016()12()StriantIMS199749002003440%2/(DentsplyInternational)25mg/25mg(Oraqix)3020FDA2004GMP2004Oraqix2(bitterblockers)2003(Linguagen)(AMP)FDA200417(NanoCrystal)(AHP)(silolimus)(Rapamune)FDA(Elan)1%1500()()()()()PfizerNeurontin(gabapentin)NaCa218(PHN)Datamonitor(diabeticneuropathicpainDNP)DNPDNPDNPDNPDNP20200311FDApregabalinLyrica-GABAGABA319(ximelagatran)ExantaAF21()2000AF/1IaIcIIIIIIVVOthersIIIVIIIIScheringAGBetapaceAFCordarone2003()3MTambocor(flecainide)Rythmol/Rytmonorm(propafenone)CordaroneTambocor23(theSinusandAllergyHealthPartnership)AbbottOmnicef(cefdinir)(ABRS)2000ABRSOmnicefABRS464646Omnicef48ABRS2(1)46(2)46ABRS1999ABRSOmnicef199712FDAOmnicef61225β-β-/β-β-β-OmnicefOmnicefOmnicefOmnicefOmnicef6Omnicef(8%)(3%