国际上治疗心血管病及其相关疾病新药的开发与研究

©1994-2009ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(17)160520091817[],,,:[phone],E2mail:duhz168@sina1com,,,(,100039)[](PhRMA)270,,,,[];;;[]R984;R97911[]A[]100323734(2009)17-1605-10InternationaldevelopmentandresearchofnewmedicinesforcardiovasculardiseasesandrelateddiseasesDUHai2zhou,LIUGui2ling,LIUNa,LBTing(MedicalLibraryoftheChinesePLA,Beijing100039,China)[Abstract]Inthispaper,wedescribedtheinternationalincidenceandtreatmentofcardiovasculardiseasesinthelastfewyears.Morethan270newmedicinesareinternationallydevelopedtotreatandpreventcardiovasculardiseasesandtherelateddiseases.WereviewedandoutlinedthesemedicinesbasedontheMedicinesinDevelop2mentDatabasecreatedbythePharmaceuticalResearchandandManufacturersofAmerica(PhRMA)andrelatedliterature.Thenewmedicinesforthetreatmentofthediseaseswithhigherincidence,suchasacutecoronarysyn2drome(ACS),atherosclerosis,hypertensionandthrombosis,arealsoanalyzedanddiscussed.Inconclusion,thenumberofthenewmedicinesforcardiovasculardiseasesinPhaseIandPhaseIIisless;manyofthenewmedicinesinclinicaldevelopmentareapprovedasmedicinesforotherdiseases;thepercentageofbiotechnologymedicinesisveryhigh.[Keywords]cardiovasculardiseases;heartdisease;stroke,newmedicines1,[1],,25,,20051750,30%;,760,570;80%,20152000(),2030,200417102340Fox[2]19967-20061251411344372,1999814%2005416%,20,,©1994-2009ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(17)160620091817(PhRMA)[3],2771Tauzin[4],277,16277,,,(apixaban)3,3,,,Cardiomever2nakalant(KynapidTM),2007FDA,b,2,357(1)357250,70%,30%16207,:40(42),37(38),32(33),3130(32),226;247220(226),63%64%,,(Aranesp),CardiumVGenerxTM;,(Crestor)FDA1/163766/72414211/13/1736837/38161661144319/2088430/3212137319121061514/1583424515432/331117515/164391976640/42151314267514343/357116134107:2211(acutecoronarysyn2drome,ACS)ACS,,[5]2007,16ACS,417%,6,3(),123(EffientTM),,,P2Y12[6]32007122620082FDA©1994-2009ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(17)160720091817(EMEA)(PCI)ACS,20097102ACS,(Angio2max),20,20001215FDA(PTCA);2007811FDA(sNDA),ACS,ST,2(Arixtra),20011210FDA2006731EMEAFDAACSsN2DA,EMEA200793,FDA[7],(MillenniumPharmaceuticals,Inc1)(Integrilin)CVTherapeuticsInc1(RanexaTM)b/a,;,2008116FDA,ACS212(atherosclerosis,AS)AS,,2007,37(38)AS,1018%37,6,/(MK20524A)2007625TredaptiveEMEA,8CordaptiveTMFDAEMEA200871127[8]2008428FDACordaptiveTM,FDACordaptiveTM,[9]620,FDA[10],FDA,MK20524A,(LDL2C),(HDL2C)AS,2(Acomplia)56I(CB1),AS21320%40%59%[11],,,31,9%10FDA(Avalide)sNDA,20071119[12]ForestMy2lan(BystolicTM)200712FDA2,qd,,65;[13],(CleveloxTM)20077FDA,2008812002,20033,,[14]/(Azor)2007926©1994-2009ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(17)160820091817,ScieleAddrenex(CoregCR),214,,:,40(42),1117%,14,2(Lovenox)(LMWH),1993329FDA,967(),Q(ST)(DVT)[15]2007,FDA,[4],Xa(Xarelto)200710EMEA,2008730(HealthCanada)FDA[16-17]2008916[18],200810EMEA[19]FDA322//(prasugrel,CS2747,EffientTM)c;2009710(bivalirudin,Angiomax)b(fondaparinux,Arixtra);AdolarCorporation(eptifibatide,Integrilin)(ranolazine,RanexaTM)CVTherapeuticsInc./(ezetimibe/simvastatin,Vytorin);MC21c(CABG)(ranolazine,RanexaTM)CVTherapeutics,Inc1()2008115(azimilide)cpexelizumabAlexionPharmaceuticalsInc1;(abciximab,ReoPro)Centocor,Inc1;(enoxaparinsodium,Lovenox)2a(erythropoietinsodium,Lovenox)22007516©1994-2009ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(17)160920091817(2)//\anacetrapib(MK20859)cb(azimilide)c,,,darapladib(Lp2PLA2)c(dronedarone,SR33589,Multaq)c2;200971succinobucol(AGI21067)c;AtheroGenics,Inc1tecadenosoncCVTherapeutics,Inc1(tedisamil,Pulzium)cSolvayPharmaceuticals,Inc1avernakalant(KynapidTM)cCardiomePharmaCorp1()a(idrapar2inux)2anacetrapib(MK20859)cbdarapladib(Lp2PLA2)csuccinobucol(AGI21067)c;AtheroGenics,Inc1(rimanobant,SR141716,Acomplia)2(rosuvastatincalcium,Crestor)/(niacin/laropiprant,MK20524A,Tredaptive)a//(niacin/laropiprant/simvastatin,MK20524B)(everolimus,Certican)zotarolimus(EndeavorTM)Medtronic,Inc1200821(paclitaxel,Taxol)ConorMedsystems,LLCalferminogenetadenovec(GenerxTM)cCardiumTherapeutics,Inc1b(bucindolol)caKW23902c()NovaCardia,Inc1(tolvaptan,OPC241061)cCelacadeTM()cVasogen,Inc1(levosimendan,Simdax)c(nebivolol,BystolicTM)cForestLaboratories,Inc1;MylanPharma2ceuticals,Inc1(irbesartan,Avapro);2darbepoetinalfa(Aranesp,)b(rosuvastatincalcium,Crestor)©1994-2009ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(17)161020091817(2)//(levosimendan,Simdax)(spirapril,Renormax)Darusentanc(clonidine,CloniBID)cScielePharma,Inc1;AddrenexPharma2ceuticals,Inc1a(moxonidine)SolvayPharmaceuticals,Inc1(nebivolol,BystolicTM)ForestLaboratories,Inc1;MylanPhar2maceuticals,Inc120071217/(estradiol/drospirenone,Angeliq)(irbesartan,Avalide);220