磁性药物-无机纳米复合材料的结构设计与表征

4924200412*DavidG.Evans*(,100029.*,E-mail:[e-mail],[e-mail]),,(Captopril:Cpl)5-(5-aminosalicylicacid:5-ASA),5-Cpl-LDHs/MgFe2O45-ASA-LDHs/MgFe2O4.,,Cpl-LDHs5-ASA-LDHsZn-O-MgAl-O-MgMgFe2O4,-.5-,,,(targeteddrugdeliverysystem)[1].,,.,,,.,[2].(Fe3O4),,,.Widder[3]Fe3O4,.(MgFe2O4).,[4][5].[6]-[7][8],;[9].[10,11]MgFe2O4NiFe2O4MgAl-OH-LDH/MgFe2O4(NiFe2O4),MgFe2O4(Fe3O4),,.LDHs(Layereddoublehydroxides),:[M1−x2+-Mx3+(OH)2]·An-x/n·yH2O.M2+,M3+,x,x=M3+/(M2++M3+),An-,,LDHs[12].LDHs[13],.O’Hare[14]LiAl-LDHs,pH=7.(Captopril:Cpl),[15].5-(5-aminosalicylicacid:5-ASA)[16].,,[17].,.,(ZnAl-LDHs),5-,(Cpl-LDHs/MgFe2O4)5-(5-ASA-LDHs/MgFe2O4),.-,.49242004122526[9]MgFe2O4.Mg(NO3)2·6H2O(0.033mol)Fe(NO3)3·9H2O(0.067mol)(Mg/Fe=12());NaOHNa2CO3([NaOH]=1.6{[Mg2+]+[Fe3+]},[CO32−]=2.0[Fe3+]).[18]2min,1006h,,7024hMgFe-LDHs.MgFe-LDHs,10/min9002h,,MgFe2O4.1.2-(1)Cpl-LDHs/MgFe2O4.Zn(NO3)2·6H2O(0.0142mol)Al(NO3)3·9H2O(0.0035mol)CO2;NaOH(0.0497mol)(0.0142mol)CO2;N2100mLCO2MgFe2O4{Zn(NO3)2·6H2O/MgFe2O427()},,pH9.2548h,,72h,Cpl-LDHs/MgFe2O4.(2)5-ASA-LDHs/MgFe2O4.Zn(NO3)2·6H2O(0.012mol),Al(NO3)3·9H2O(0.003mol)MgFe2O4{Zn(NO3)2·6H2O/MgFe2O4=18()},CO2;5-ASA(0.008mol)NaOH(0.038mol)CO2;N2,,,0.1mol/LNaOHpH8.4.6048h,,CO2,7012h,5-ASA-LDHs/MgFe2O4.(3).,Cpl-LDHs5-ASA-LDHs(1)(2),MgFe2O4.ZnAlCO3-LDHs/[19]:NaOH(0.038mol)Na2CO3(0.006mol);Zn(NO3)2·6H2O(0.012mol)Al(NO3)3·9H2O(0.003mol).2min,1006h,,7024hZnAlCO3-LDHs(CO3-LDHs).1.3XRD-6000X(CuKα,λ=1.5418Å,40kV,30mA,5°/min,2~70°).HITACHI-800,.VGMK,AlKα(1486.6eV),1s,3×10−7Pa.BrukerVector-22(/KBr=1/100,2cm−1,4000~400cm−1).PCT-IA(,10°/min,10mg,DTA100µV,TG10mg,1000ms).ICPS-7500(0.7L/min,14L/min,1.2L/min)Zn,Mg,FeAl.Elementarvario(200mL/min,20mL/min,950,550)C,H,N.JSM-13(VSM)(25,50mg,15kOe(1A/m=4π10−3Oe),20emu).22.1MgFe2O41MgFe-LDHs(a)MgFe2O4(b)XRD,MgFe-LDHs(1(a))LDHs(003),(006),(009)(110)[13].900,MgFe2O4(1(b))(220),(311),(400),(511)(440),JCPDS(17-0464),MgFe2O4,[11]18.7nm.2MgFe2O4[20],23.3emu/g(1emu/g=1A·m2/kg),,MgFe2O4.49242004121MgFe-LDHs(a)MgFe2O4(b)XRD2MgFe2O42.2-3Cpl-LDHs/MgFe2O4,Cpl-LDHs,5-ASA-LDHs/MgFe2O4,5-ASA-LDHsCO3-LDHsXRD,1XRD.3(a)3(c),Cpl-LDHs/MgFe2O45-ASA-LDHs/MgFe2O4LDHs,(003)d.Cpl-LDHs/MgFe2O42θ=4.05°(003),d003=2.180nm;5-ASA-LDHs/MgFe2O42θ=6.46°(003),d003=1.350nm;CO3-LDHs(2θ=1Cpl-LDHs/MgFe2O4,5-ASA-LDHs/MgFe2O4CO3-LDHsXRDCpl-LDHs/MgFe2O4ASA-LDHs/MgFe2O4CO3-LDHsd003/nm2.1801.3500.751d006/nm1.1350.8290.377d110/nm0.1520.1530.153c/nma)6.5404.0502.253a/nma)0.3040.3060.306Zn/Alb)1.5503.3003.400xc)0.3920.2300.227),acc=3d003a=2d110[15].b)ICP.c)x=Al/(Zn+Al)3Cpl-LDHs/MgFe2O4(a),Cpl-LDHs(b),5-ASA-LDHs/MgFe2O4(c),5-ASA-LDHs(d)CO3-LDHs(e)XRD*MgFe2O411.79°,d003=0.751nm),2θ,d003,Cpl5-ASALDHs[12],2θ30.36°,35.68°,43.33°,57.23°62.82°MgFe2O4,,-,Cpl-LDHs(5-ASA-LDHs)MgFe2O4,Cpl-LDHs(3(b))5-ASA-LDHs(3(d))-.4Cpl-LDHs/MgFe2O4,5-ASA-LDHs/MgFe2O4MgFe2O4IR.,Cpl-LDHs/MgFe2O4(4(a))5-ASA-LDHs/MgFe2O4(4(b))3400~3500cm−1,−OH;1595cm−1,1400cm−1–COO-,Cpl[21],,Cpl–COO-,1625cm−1,1378cm−1–COO−,49242004125-ASA1),,5-ASA–COO−,pH(~8.4)5-ASA(pka1=2.74,pka2=5.84)[22],5-ASA−COO,−NH2.N2,CO2,IRCpl-LDHs/MgFe2O41400cm−1,5-ASA-LDHs/MgFe2O41378cm1.Cpl-LDHs/MgFe2O45-ASA-LDHs/MgFe2O4578cm−1MgFe2O4(4(c)),Cpl5-ASALDHs2040cm−1,,MgFe2O4Cpl-LDHs5-ASA-LDHs.5Cpl-LDHs/MgFe2O4(a)5-ASA-LDHs/MgFe2O4(b)TG-DTAN2,CO2,Cpl-LDHs/MgFe2O45-ASA-LDHs/MgFe2O4(006).TG,Cpl-LDHs/MgFe2O45-ASA-LDHs/MgFe2O4:[Zn0.608Al0.392(OH)2](C9H13NO3S−)0.214-(CO32−)0.089·0.6H2O;[Zn0.767Al0.233(OH)2](C7H6NO3−)0.135-(CO32)0.049·0.5H2O.LDHs(2).4Cpl-LDHs/MgFe2O4(a),5-ASA-LDHs/MgFe2O4(b)MgFe2O4(c)IR2Cpl-LDHs/MgFe2O45-ASA-LDHs/MgFe2O4ICPC,H,N2.35Cpl-LDHs/MgFe2O45-ASA-LDHs/MgFe2O4TG-DTA.5(a),Cpl-LDHs/gFe2O4104,M,338534,53411.6%.5(b),5-ASA-LDHs/MgFe2O43114105-,41018.3%.ZnAlCHNS/%/%27.807.3815.063.974.782.0332.4Cpl-LDHs/MgFe2O4/%27.017.2316.544.244.692.0531.5/%40.685.129.853.081.52−17.05-ASA-LDHs/MgFe2O4/%41.695.269.973.191.5816.72.4X-Cpl-LDHs/MgFe2O45-ASA-LDHs/MgFe2O4,3.XPSXRDIR,1)SadtlerStandardSpectra.IR.33100k2528−−531.3284.55-ASA-LDHs/MgFe2O41021.974.550.0710.7535.2284.65-ASA-LDHs1021.874.3−532.6284.6MgFe2O4−48.8710.9529.9284.6[23],.FeZnAlMg,-ZnAlMgZn-O-MgAl-O-Mg,Mg2p.,-MgFe2O4Zn-O-MgAl-O-Mg,-.,5-ASA-LDHs/MgFe2O4XPS,6.5minAr+(1nm/min),5nm,Fe2p,,20minFe2p,30minFe2p3/2Fe2p1/2,.6Fe2p3/2XPS30nm,30nm.2.57Cpl-LDHs/MgFe2O4(a)5-ASA-LDHs/MgFe2O4(b)TEM.,Cpl-LDHs/MgFe2O45-ASA-LDHs/MgFe2O4LDHs.,(LDHs),MgFe2O4,.7Cpl-LDHs/MgFe2O4(a)5-ASA-LDHs/MgFe2O4(b)TEMCpl-LDHs/MgFe2O4(a)5-ASA-LDHs/MgFe2O4(b)(VSM),8.1.231.53emu/g,,.MgFe2O4,Cpl5-ASALDHsMgFe2O4,Cpl-LDHs5-ASA-LDHsMgFe2O4,Cpl-LDHs5-ASA-LDHsMgFe2O4,MgFe2O4MgFe2O4.49242004128Cpl-LDHs/MgFe2O4(a)5-ASA-LDHs/MgFe2O4(b)3(1),18.7nm.(2),5-,,5-.-MgFe2O4Zn-O-MgAl-O-Mg,.(3)Cpl-LDHs/