强效镇痛药舒芬太尼的合成-中国医药工业杂志

phramaeeutiealIndutsry1956,16(6)·1(241)·…(Sulfentanyl,)IN{41「2(2)〕4}N〔`〕。、。(Fentanyl,11)。_:、/CH20cH3QcHZcHZNX。\—/\NCcHS`5CHczHZVCOCZHSCOCZHSEP。。0.71gk/g(i·v·),4,521,363「2,3,。,8~15「`,`〕。,0.7gk/g,60~70r6〕。:/、KCN。C;H、NH,/、/HSCHZN)O—--C5CHZNX、/、/、HZSQ;.NC6HSjHC5CHZCONHZNC6HS!HHCI,NaOH—CH3OH,HZSQ4/COZCH3c6HScHZ_、_,、NHLIAIH-/-、/CHZOHC6HS`HZNX\\NC6HSM50—”cHZlHCHZOCH3NC6HS}H(C3CHZCO)20--qHScHZGHZOCH3NC15}CQCZH`H3COCZHCHZCHZS03CH3(19,)————I-·HZ`47“,2(2),,,50~70oC24h,47。2(2)2,〔7〕2(2),a(2)。.1(2).Phamr`ceuti1Induy1985,16(6)、N(4)N『(),111。、2(2)150ml,3.89,30210950ml,Zh。30ml250ml。,,,。,138~139℃/80mmHg,2(2)59(),n1.6482,66.6(〔7,:bPI1~i16oC/7mmHg)。。〔”2(2),n1.5801,42。、(I)X39(0.0011mol)、2(2)29(0.0011mol)、1.59(0.015mol)30ml,3h,50~70℃24h。50ml,,。,(15)。,30~60℃,,,,29,mp65~96OC,47。(:mp96.6“C)。(C22HsoNZOZS):C、H、N、S0.3。:,(=C-O)1646em`,M+386。:al:al:al[1]JassnenPAJetal:ArzneimFosreh1976,26:1621[,」idem:ibid1976,26:1661[3〕NoaehEL:AnaesthesiaandPharmaeology,edbyJ.hSpiedijik,1976,ppg,~111,LeidenUniversityPressHenklerGKalenda2etKubickiSTGiumaniniAG,Phannazie1979,34:609Anaesthesist1976,25:380ibid1977,26:333etal:JOrgChem1976,41:,J,.JJesJ465óIrJ.`rL.LJSYNTHESISOFPOTENTANAIJGESICSSULFENTANYLYangZhiiie,andZhangJinbao(I、s`i、toofChe,fcolDfee,e`,A)ABSTRACTAnimPrvoedySnthetiemethdoofZ(2thienyl)bromoethaneandN「4(methxymetilyl)4PIPeridinyl」~NPhenylPrOPOInamidein47yield.〔19841115〕