药物制剂开发

20082910MARKETINGINVESTIGATION:R97:D:1006-1533(2008)10-0453-06,50,2002-200539%1(1)1986,,,(2002)1200710()()(%)()Nexium43.567.3/AdvairDiskus33.918.8()Prevacid33.160.3EffexorXR24.649.7()Protonix21.375.7/Vytorin19.3932.0/Hydrocodone/APWP17.367.0Cymbalta17.3359.8AdderallXR12.8913.9OxycodoneER12.5322.6TriCor11.0714.6/DiovanHCT10.5221.4OxyContin10.4452.8Concerta10.3110.1,:20009%201021%(2),22000-20102000(%)2010(%)6237OTC152314199211.1,,10,20074.81,2012801.1.1Cervarix,Cervarix,26,1.1.2DCVax-Brain(Northwest),()35420082910,,DCVax(3),,1.1.3(vitespen)(Antigenics)(:Oncoph2age),,Oncophage1.2,2011201620214108401750,,1.2.1(Epeius)()(:Rexin-G),,Rexin-G100nm,,,,Rexin-G,Rexin-G,,1.2.2(DaburPharma)(:Nanoxel),cremophor,,,,cremophor,Nanoxel,1.2.3(Smith&Neph2ew)ActicoatActicoatSil2cryst,30,NPI3210122008-2010,NME(3),,,2008-201010%-20%32008-2010Fosamax2008.2.6SereventAllenHanburys2008.2.12Camptosar2008.2.20ZemuronAkzo-Organ2008.4.13Zerit2008.6.25ZymarAllergan2008.6.25Depakote2008.6.29Dovonex2008.6.29Kytril2008.6.29Casodex2008.10.1Trusopt2008.10.28Zerit2008.12.24Lamictal2009.1.22VexolAlcon2009.1.22Epivir2009.2.8454200829103Avandia2009.2.28Topamax2009.3.26PrevacidTapPharm2009.5.10Glyset2009.7.27Cozaar2009.10.6Acular2009.11.5Xenical2009.12.18Valtrex2009.12.23Avelox2009.12.30Neurotin2010.1.2Famvir2010.9.21Inverase2010.11.19Ariceot2010.11.25Sigular2010.11.302010,38,,20072011,,2.1(paliperidone)NME,,2.21(Alkermes)(Medisorb)(:RisperdalConsta),,PLG,,,,,,2.3(Alza)OROS(:Invega),12.4,(ADHD)27,201533,,20008,FDA1(:Concerta),ADHDConcerta,,12hConcerta,,ADHD,200710.31,10%20064,FDA(Shire)(:Daytrana),ADHD1,:10152030mg/(Noven)(DOTMatrix),,Daytrana,,(9h),Daytrana9h12h,3(4)554200829104,,11,1/,/,13,,3.1,20101290,(46%),200253%(5):,11%,2007156,2010215,2015362,/(6)520102010(%)46161610846SonoPrep(SontraMedi2cal)/Synera(ZarsPharma)Ionsys-(Janssen-Cilag)Mhi-500(TheMedi2calHousePLC)Vitajet3Biojector2000Estrasorb(Novavxa)EvaMis(Vivus)LoxoninTape-Flector(InstitutBiochimiqueSA)FlexoganUltra(AlphaAP)ExelonPatchDaytranaEmsamOxytrol(Watscon)-(Aveva)654200829103.23.2.1(:Exu2bera)200891,Alkermes/AIRAradigm/(NovoNordisk)AERxKos(7)7(1000IU/5mL)Aradigm(AERxiDMS)/(,204080IU/)Generex(Oralin)/AlkermesEmisphere(Eligen)KosMankindCorpNobexBiocon(HIM-2)Cortecs3.2.2(Cephalon)(:Fentora),Fentora:100200400600800g/Fentora,1998(Cima)OraVescentFentora,,pH,3.33.3.1(ibandronatesodium)12005,1150mg(:Boniva),1112,2006,13mg(:BonivaInjec2tion)1520sec,3060min()3.3.21(:Reclast,Aclasta),:5mg/100mL,115min3.4:(:TriCor),TriCorLDLB,HDL,,,35%48145mg/,50160mg/,3.520071,FDA-/3mg/0.02mg(:Yaz),FDA320063,FDAYaz;10Yaz3.6,3.6.1(Santarus)75420082910/20mg/1100mg40mg/1100mg(:Zegerid)//20mg/600mg/700mg40mg/600mg/700mg(:ZegeridChewableTablets),,(48wk),,Zegerid(),,3.6.2(:Abrax2ane),6,(AmericanBioScience),,50%30minCre2mophor-ELTaxol,3h3.73.7.1//(:Caduet),/5mg/10mg5mg/20mg5mg/40mg5mg/80mg10mg/10mg10mg/20mg10mg/40mg10mg/80mg5mg,10mgCaduet13.7.2(Gilead)(efavirenz)/(emtricitabine)/(tenofovirdisoproxilfumarate)600mg/200mg/300mg/(:Atripla),HIV-1HIV11,(:Sustiva)/(:Truvada)Truvada113.7.3(AxcanPharma)(biskalcitratepotassium)//140mg/125mg/125mg/(:Pylera),NME,Pylera2018275Pylera220mgOAC(20mg/1g/500mg,2),,Pylera(88%)OAC(83%)3.83.8.1(:ImitrexInjection)ImitrexSTATdoseSystem,4mg,6mg3.8.225%(:Buminate)50200510,FDA25%(:Flexbumin),:50mL100mL/Galaxy,2Flexbumin,,3.8.3(:Asmanex),DuPont,,,,,,(:2008-09-02)854