饮酒、肥胖与脂肪肝关系的流行病学调查

,B31757.62%41.9%20.82%661,92.43%3.48%,3.6(95%CI,1.111.7)11.6(95%CI,8.216.5),17.1(95%CI,9.132.4);4.8(95%CI,1.416.6),(OR=1.5,95%CI,0.92.6),;;;EpidemiologicallysurveyonrelationoffattyliverwithalcoholdrinkingandobesityFANJian2gao3,ZHUJun,LIXing2jian,LIRui,DAIFei,SONGXiao2min,LIUTian2su,LIFeng,CHENShi2yao.3DiseaseCenterforFattyLiver,ShanghaiFirstPeoplesHospitalAffiliatedtoJiaoTongUniversity,Shanghai200080,ChinaAbstractObjectiveToinvestigaterelationoffattyliverwithalcoholdrinkingandobesity.MethodsUsingrandomizedmultistagestratifiedclustersampling,investigationsincludingquestionnaires,physicalexaminations,oralglucosetolerancetests,bloodlipidtests,andreal-timeliverultrasonographicssubjectswereadultsageoverthe16in8residentialareasofShanghaicity.Results3175adultswereenrolledconsistedof1218malesand1426females,withameanageof52.415.1years.Theprevalenceofdrinkingmonthlyandobesitywere7.62%and41.9%,respectively.Ultrasonographydetectedfattyliverin661(20.82%)cases:3.48%werealcoholicfattyliver,and92.43%werenonalcoholicfattyliver.Comparedwithcontrols,theriskforfattyliverwashigherby3.6fold(95%CI,1.1-11.7)inheavydrinkers,11.6fold(95%CI,8.2-16.5)inobesepersons,and17.1fold(95%CI,9.1-32.4)inpersonswhowerebothobeseandheavydrinking.Inheavydrinkers,obesityincreasedtheriskforfattyliverby4.8fold(95%CI,1.4-16.6),butheavydrinkingnotsignificantly(95%CI,0.9-2.6)increasedtheriskforfattyliverinobesesubjects.ConclusionThereisahighprevalenceoffattyliver,predominantlynonalcoholicfattyliver,intheadultpopulationofShanghai.Obesityandassociatedmultiplemetabolicdisordersaremorecloselyrelatedtofattyliverthanexcessivedrinking.KeywordsFattyliver;Epidemiology;Alcoholdrinking;Obesity:200080();();();();(),[1,2],,,,16,,11(30)(26),4,,(500),20021020034,16,B5%B,Kappa97120059103,,,(BMI)P(WHR)1B,12,12(gPd),10gPd1029.99gPd30gPd2000WHO,BMI2325kgPm2,BMI25kgPm22002[3,4],t,22,P0.05(OR)95%(CI)164205,3834,31751218,()1957;1688,(52.415.1),2000,2.26P10000;,(P0.001)3175,242(7.62%),(17.73%1.33%,P0.0001);1331(41.9%),(44.7%40.1%,P=0.011);661(20.82%),(21.18%20.59%,P=0.6908),8.19%35.49%17.29%,(14.51%1.51%,43.16%31.28%,19.30%15.08%,P0.01)(P0.001)3175,2933,55,104,831,,,(P0.01),BMI,,18.07%14.68%(P0.05)32.53%20.50%(P0.0001);(++),25.21%20.46%(P0.01)661611(92.43%)23(3.48%)27(4.08%),88.78%4.53%6.69%,15.35%0.79%1.15%1(gPd)0101029.93029335510483(%)1002(34.2)38(69.1)96(92.3)82(98.8)(%)1931(65.8)17(30.9)8(7.7)1(1.2)()51.115.455.7011.0055.4011.8053.509.90(g)03.300.8019.704.6045.2011.90BMI(kgPm2)24.495.6025.483.0324.303.4625.184.79(cm)80.1010.1081.708.6579.409.4083.709.30(%)431(14.69)8(14.55)15(14.29)15(18.07)(%)600(20.46)13(23.64)21(20.19)27(32.53)3:0,3P0.01081ChineseHepatology,Sep2005,Vol10,No.3WHOBMI,(1049),BMI23kgPm2,10gPd100kg;(25),BMI23kgPm2,30gPd()100kg;(1252),BMI25kgPm2,10gPd100kg;+(35),BMI25kgPm2,30gPd()100kg2,BMI,,3.6,11.6,+17.14.8(P0.05),1.5(P=0.1685),3.2(P0.05)2()BMI()(kgPm2)(gPd)(kg)49.515.421.21.33.51.423.54.152.716.122.11.252.133.73534.1324.8352.917.528.52.134.82.749.742.4+53.615.428.72.8362.342.93732.5541.93:33P0.001,,[5],35.1%;[6]18237(66.0%),26.96%,8.19%,(14.51%1.51%),,35.49%17.29%,,,,,;,,[7],265,72.8%,7.2%[8],,88.78%,4.53%,Bellentani[9],,+3.611.617.1,5;,1.,,,.4009.,1998,6:17219.2...,2002,22:1062107.3...,2003,11:70.4...,2003,11:71.5.,,,..,2002,10:4672468.6.,,,..,2003,11:6472649.7.JquierE.Alcoholintakeandbodyweight:aparadox.AmJClinNutr,1999,69:1732174.8.,,,.265.,1998,21:68270.9.BellentaniS,SaccoccioG,MasuttiF,etal.PrevalenceofriskfactorsforhepaticsteatosisinNorthernItaly.AnnInternMed,2000,132:1122117.(:2005204203)18120059103