天然产物中抗艾滋病病毒活性成分的研究进展

天然产物中抗艾滋病病毒活性成分的研究进展田瑛,董俊兴(,100850):介绍具有抗HIV活性的天然产物的研究概况根据国内外资料进行汇总综述具有抗HIV活性的化学成分有多糖类蛋白质和肽类生物碱类香豆素类黄酮类木脂素类酚酸类醌类萜类等天然产物的开发和利用将给AIDS的防治带来希望:艾滋病;抗艾滋病病毒;活性成分:R284;R373:A:1001-2484(2002)06-0401-06:,Tel:[phone](AIDS)1981(CenterforDiseaseControlinAmerican,CDC),20,,,(HIV),,,,HIV1AIDSHIV,100nm,gp41gp120,p17,p24,RNAHIVCD4,:HIV,CD4,,,RNADNA,DNADNA(cDNA)cDNA,,,,,RNA,,mRNA,,HIV,,,2AIDSHIVHIV1,131天然产物中抗HIV活性成分()ASAEHIV-RT1~7911,HIV-RT,-Meretrixpetechialis()RAPRhizophoraapiculatamRNARMPMRA-10HIVp24,MGN-3HIVp24BniphatevirinNipthateserectaCD4gp1208~-,-cowpedHIV-RTHIV-16trichobitacin()RNA,HIVHIVMAP30()DAP30,DAP32PAPGAP31GeloniumMultiflorum()MHLMyrianthusholstii,gp120microspinosamideSidonopsmicrospinosaHIVcirculinsA-FChassaliaparvifoliaHIVC1-methoxycanthinoneLeitneriaforidanaHIVH917~40120026376ChinPharmJ,2002June,Vol.37No.61()CsiamenolMurrayasiamensisHIV21triptonineBHIVkorundamineAAncistrocladuskorupensisHIVmichellaminesB(1)AncistrocladuskorupensisHIV:HIV-RT;HIV(Ancistrocladaceae):,O-Cephaclisipecacuanha---HIV-RTschumannificineSchumanniophytomagnificumgp120HIV,australineHIVDcalanolideA,calanolideBCalophyllumlanigerum()HIV-RTDNADNA22~RNADNA24soulattrolide(2)Calophyllumteysmannii()HIV-RTinophyllumsB,P()HIV-RTpabulenol(3)H9HIVH9suksdorfinHIVHIVglycocoumarinHIV,licopyranocoumarinE(-)Detariummicrocarpumgp120HIV25~(-)-3-O-30(-)CamelliasinensisRNADNA(-)RTHIVp24,HIV-RT,gp120CD4HIV23(4,5)2--O-(6-O-)--D-gp120,,(6)3-O-methylcalopocarpin(7)ErythrinaglaucaWilldHIVsandwicensis(8)3-O--D-(Euphorbiaceae)-7-O--D-HIV-7-O--D--3-O-(2,6-O-)--D-AcerokamotomanumHIV-3-O-(2-)--L-amentoflavone,agathisflavone,robustaflavone,inok-iRhussuccedaneaGarciniamultifloraHIV-RTflavone,morelloflavone,GB-1a,GB-2a(9~15)(16)BidensLeucanthaswertifranchchesideSwertiafranchetiana()HIV-RTDNAliochalconeA,isolicoflavonol,glycyrrhizoflavoneHIVF(-)-arctigeninForsythiaintermediaHIV,31~(-)-trachelogeninDNA32interiotherinAHIVschisantherinDFBI-FB5(17-21)FB2HIVtermillignan(22)HIVthannilignan(23)G3,4,5--O-gp12033~4,5--O-CD4,383,4,5--O-GuierasenegalensisNaKArnebiaeuchoma,HIV(p17/p24)402ChinPharmJ,2002June,Vol.37No.6200263761()GHIVHIVCD4LTR,HIV,HIV-1HIV-2,magnesiumlithospermate(24)Cordiaspinescens(Boraginaceae),,calciumrosmarinate(25)magnesiumrosmarinat(26)peltatolsA,B,CPothomorphapeltataHIVSaniculaenropaeal.(apiaceae)HIV-RTmallotojapoin(27)HIV-RTmallotochromeneprotolichesterinicacidCetrariaislandicaAHIVdaphnodorinB(28)dibalanocarpolHopeamalibatobalanocarpolvismiaphenoneDVismiacayennensisHavarolDysideacinerea(dNTP)39~avarone40illimaquinoneSmenospongiaHIV-RTH(RnaseH)conocurvoneConospermumsp.HIVHIV,HIVHIV-macluraxanthoneB(29)MacluratinctoriaHIVmacluraxanthoneCisocyclomulberrinI(30)HIV,41~16beta17-dihydroxy-en-tkauran-19-oicacidHIV48methy-l16alpha-hydro-19-a-len-tkauran-17-oateAnnonaglabraHIV16alpha-17-dihydroxy-en-tkauran-19-oicacidHIV-RT12-O-Acetyphorbo-l13-deanoate12-O-decanoyipiorbo-l13-(-2-methylbutyrate)HIV12-O-teradecanoylphorbo-l13-acetatelancilactoneC(31)kadsuralancilimbaHIVRosawoodsii,prosopisglandulosaHIVH9gandoderiolFHIVganodermanontriolganodericacidBganoderiolBnigranoicacid(32)HIV-RTSyzygiumclaviflorumHIVplatanicacid,HIVCrataeguspinnatifidaescina,b,vc,vd,ve,vfisoescina,b(33~40)CH9HIVgymnocladussaponinGDNARNA(HIV),HIV:A-;B-;C-;D-;E-;F-;G-;H-;I-,HIV:CD4;;;;;HIVHIV,,,:40320026376ChinPharmJ,2002June,Vol.37No.6,AIDS1天然产物中抗艾滋病病毒活性成分的化学结构[1],,,.911HIV-1[J].,2000,19(3):8.[2],,,.911911[J].,2001,20(1):17.[3]AmornrutC,ToidaT,ImanariT,etal.Anewsulfatedbeta-galactanformclamswithant-iHIVactivity[J].CarbohydrRes,1999,321(1-2):121.[4],,,.HIV-1[J].,2000,14(1):56.[5]PremanathanM,ArakakiR,IzumiH,etal.Antiviralpropertiesofamangroveplant,RhizophoraapiculataBlume,againsthumanimmunodeficiencyvirus[J].AntiviralRes,1999,44(2):113.[6]PremanathanM,KathiresanK,YamamotoN,etal.Invitroan-t-ihumanimmunodeficiencyvirusactivityofpolysaccharidefromRhizophoramucronataPoir[J].BiosciBiotechnolBiochem,404ChinPharmJ,2002June,Vol.37No.6200263761999,63(7):1187.[7]GhoneumM.Ant-iHIVactivityinvitroofMGN-3,anactivityarabinovylanfromricebran[J].BiochemBiophysResCommun,1998,243(1):25.[8]OkeefeBR,BeutlerJA,CardellinaJH2nd,etal.Isolationandcharacterizationofnepatevirin,ahuman-immunodeficiency-virus-inhibitoryglycoproteinfromthemarinespongeNiphateserecta[J].EurJBiochem,1997,245(1):47.[9]YeXY,WangHX,NgTB,etal.StructurallydissimiliarproteinswithantiviralandantifungalpotencyfromCowpea(vignaunguic-ulata)seeds[J].LifeSci,2000,67(26):3199.[10]ZhengYT,BenKL,JinSW,etal.Ant-iHIV-1activityoftr-ichobitacin,anovelribosomeinactivatingprotein[J].ActaPhar-macolSini,2000,21(2):179.[11]deClercqE.Currentleadnaturalproductsforthechemotherapyofhumanimmunodeficiencyvirus(HIV)infection[J].MedResRev,2000,20(5):323.[12]RajamohanF,EngstromCR,PentonTJ,etal.High-levelexpres-sionandpurificationofbiologicallyactiverecombinantpokeweedantiviralprotein[J].ProteinExprPurif,1999,16(2):359.[13]AuTk,CollinsRA,LamTL,etal.Theplantribosomeinactivat-ingproteinsluffinandsaporinarepotentinhibitorsofHIV-1inte-grase[J].FEBSLett,2000,471(2-3):169.[14]CharanRD,