废用性肌萎缩的治疗方法综述

200241、。。G804.55A1007－6204200902－0046－02LIAONINGSPORTSCIENCEANDTECHNOLOGYVol．31No．2Apr．200931220094。、。、、[1]。、。。1。。1.1。[2]F“”、。。1.2。。[3]。。。[4]1.3。,、。、。。。、、ROS、[5][6]。22.1。ATP[7]。2008-10-172009-02-101983-。AnoverviewonthetherapeuticmethodofmuscularatrophyofdisuseZHANGNan-nanLIShi-changSportsandHealthSchoolofHuadongNormalUniversity,Shanghai200241AbstractThemostsignificantchangingofmusculatureisthemuscularatrophyunderthedisusedsituation,whichobvious－lychangesnotonlyinitsshapeandstructure,butalsoinmetabolicandfunction;butitsmechanismisnotclearnow.So,itisverynecessarytoquestthemechanismofthemuscularatrophyofdisuse,andtofindoutanefficientmethodofcuringandpreventingthemuscularatrophy.Keywordsskeletalmuscle;disuse;muscularatrophy;recovery;kinesitherapy46··。、。2.1.1、。[7]、、、。[8]、。[9]。[10]、。[11]。2．1．2。。[1213]2．1．3。。[7]2．2。。、、。、。[9]2．2．1、。[7]。[2]2．2．2。[9]2．2．3。2．2．4[14]352。、、、。2．3。1IGF-I[9]2rhGH[15]3E[16]4[17]5Ca2+nifedipine[18]6[19]72CRF2R[20]8ND[21]9[9]1、、、[22]2、[23]3、[24]4EGb761[25]5、、[26]。3。、、。[1]MachaelK.Relationshipofskeletalmuscleatrophytofunctionalsta－tusasystematicresearchreview．BiolReaNurs200222117-31.[2].[J]．．2004204145-150[3]Williams．Microsurgery19961711589-596[4]QinLetal．ArchPhysMedRehabil1997785512-517.[5]MalcolmJ．Jackson．FreeradicalsgeneratedbycontractingmuscleBy-productsofmetabolismorkeyregulatorsofmusclefunction?FreeRadicalBiology[J].Medicine2008442132-141．[6]L.J.S.GreenlundK．S．Nair．Sarcopenia-consequencesmechanismsandpotentialtherapies[J]．MechAgingDev2003124287-299．[7]．[J]．200375710-714.[8]．[J]．199720133-5.[9]．[J].20048358060-8063.[10]SakakimaHYoshidaYSakaeKeta1．Differentfrequencytreadmillrunninginimmobilization-inducedmuscleatrophyandanklejoint－contractureOfrats．Scand[J].MedSciSports2004143186-92.[11]．[J].2002212166-9.[12]．[M].1996150.491522009247··47[13].68[J].2000471074.[14]JOURNALOFTAISHANMEDICALCOLLEGE1996173[15]VandenburghH,DelTattoM,ShanskyJ,etal.Attenuationofskeletalmusclewastingwithrecombinanthumangrowthhormonese－cretedfromatissue-engineeredbioartificialmuscle[J].HumGeneTher19989172555-64.[16]AppellHJetal.IntJsportsMed1997183157-160.[17]Op’tEijndeBUrsoBRichterEAetal.EffectoforalcreatenesupplementationonhumanmuscleGLUT4proteincontentafterim－mobileization.Diabetes200150118-23.[18]SoaresJMetal.IntJSportsMed1993148437-439.[19]AboudrarSetal.JApplPhysiol19937562767-2773.[20]HinkleRTDonnellyECodyDBetal.ActionoftheCRT2re－ceptormodulatesskeletallmusclemassunderphysicalogicalandpathologyicalconditions.AmJPhysiolEndocrinolMetab20032854E889-98.[21]BouhlelAJoumaaWHleotyC.Nandrolonedecanoatereduceschangesinducedbyhindlimbsuspendsioninvoltage-dependenttensionofratsoleusmuscleJpnJPhysiol2003,53277-87.[22].[J].1999124281-283.[23].[D].20051148-57.[24].[J].2002154250-254.[25].、[J].20001611681-684.[26].[J].20051814423-424.。2.65。P0.01。、。。2.75。P0.05。。33.13.1.1、、、。3.1.25、、、、。3.23．2．13.2．1．1、。3．2．1．2。3．2．1．3。3．2．1．4、。3.2．23．2．2．1。3.2．2．2、、。3.2．2．3。3．2．2．4。[1].[J].20043.[2].[J].20035．[3].[J].20062.[4].SPSS[M].200036-38.[5].[J]．20071．[6].[J].20026．[7].[J].20049.[8].[J].200l1.[9].[J].20013.15220092!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!49··