底物、抑制剂、诱导剂列表

HowtoUseThisTableThistableisanabridgedguidetoP-450druginteractionswhichcanbegreatlyexacerbatedbycommongeneticvariations(presentinhalfofthepopulation).Toappreciatethefullbenefitsofthisinformation,goto(mainpathwayformetabolism)italics=minorpathwaybold=onlypathwayNAT21A22D62C92C193A4,5,7caffeinecaspofungindapsonehydralazineisoniazidnitrazepamprocainamideretigabinesulfadiazinezonisamideSulfonamides:sulfapyridinesulfamethazinesulfadiazinesulfasalazinecarcinogenicaromaticandheterocyclicaminesbenzidinebeta-naphthylamineAnalgesics:acetaminophenAntidepressants:amitriptylinebrofaraminebupropionclomipraminedoxepinfluvoxamineimipraminemaprotlinemirtazapineAnti-epileptics:carbamazepineAntipsychotics:chlorpromazineclozapinefluphenazinehaloperidololanzapineperphenazinepimozidethioridazineCardiovascular:brofaramineflecainidelidocainemexiletinepropafenonepropranololverapamilHIVAntivirals:ritonavirNSAIDs:NaproxenMiscellaneous:caffeinecyclobenzaprineclopidogrelflutamidefrovatriptanmelatoninmetoclopramideondansetronproguanilquininerifabutinriluzoleranitidineropivacainetacrineteniposidetheophyllinewarfarinzileutonzolmitriptanzolpidemAnalgesics:acetaminophenhydrocodonemethadoneoxycodonetramadolAntidepressants:amitriptylinebrofaraminebupropionclomipraminedesipraminedoxepinfluoxetinefluvoxamineimipraminemaprotlinemirtazapinenortriptylineparoxetinetrazodonetrimipraminevenlafaxineAntihistamines:chlorpheniramineAntipsychotics:chlorpromazinefluphenazinehaloperidolmesoridazineolanzapineperphenazinerisperidonethioridazineCardiovascular:alprenololcarvedilolflecainidemetoprololmexiletinepropafenonepropranololverapamilAnti-ADHDamphetaminesatomoxetineHIVAntivirals:amprenavirdelavirdineritonavirHMGCoAReductaseInhibitors:simvastatinMiscellaneous:amphetaminebuspironechloroquinecyclobenzaprinedextromethorphandoxorubicinmetoclopramideondansetronranitidinetacrinetamoxifentimololAnalgesics:methadoneAngiotensinIIBlockers:irbesartanlosartanAntibiotics:rifampinAntidepressants:amitriptylinebupropionfluoxetinesertralinetrimipramineAnti-epileptics:phenytoinCardiovascular:carvedilolquinidinediltiazemHIVAntivirals:amprenavirHormone:progesteroneHMGCoAReductaseInhibitors:fluvastatinlovastatinNSAIDs:celecoxibdiclofenacibuprofenindomethacinmefenamicacidmeloxicamnaproxenpiroxicamsuprofenOralHypoglycemics:glimepirideglipizideglyburidetolbutamideProtonPumpInhibitors:omeprazoleMiscellaneous:cyclophosphamidedextromethorphandapsoneesomeprazolehalofantrinephenobarbitalmephobarbitalsildenafilsulfamethoxazoletorsemidevalproicacidwarfarinzafirlukastzileutonzolpidemAnalgesics:methadoneAntidepressants:amitriptylineclomipraminecitalopramdoxepinfluoxetineimipraminemaclobemidesertralinetrimipramineAnti-epileptics:diazepammephenytoinphenobarbitonephenytoinprimidoneS-mephenytoinAntipsychotics:perphenazinethioridazineBenzodiazepines:alprazolamdiazepamCardiovascular:propranololHIVAntivirals:nelfinavirHormone:progesteroneNSAIDs:IndomethacinOralHypoglycemics:glyburidetolbutamideProtonPumpInhibitors:esomeprazolelansoprazoleomeprazolepantoprazoleMiscellaneous:carisoprodolcyclophosphamidedextromethorphandapsonemephobarbitalnilutamidephenobarbitalproguanilquinineranitidinetamoxifenAnalgesics:acetaminophenfentanylmethadonetramadolAngiotensinIIBlockers:irbesartanlosartanAntibiotics:azithromycinclarithromycindirithromycinerythromycinrifabutinrifampinAntidepressants:bupropionclomipramineimipraminefluoxetinefluvoxaminemirtazapinenefazodonenortriptylinesertralinetrazodonevenlafaxineAnti-epileptics:carbamazepinediazepamethosuximidefelbamatetiagabineAntihistamines:astemizoleterfenadineAntipsychotics:haloperidolperphenazinepimoziderisperidoneBenzodiazepines:alprazolamdiazepamtriazolamCardiovascular:amlodipineamiodaronecarvediloldiltiazemeplerenonefelodipinelercanidipinelidocainenicardipinenifedipinenisoldipinepropafenonequinidineverapamilHIVAntivirals:amprenavirdelavirdineefavirenzindinavirnelfinavirritonavirsaquinavirHMGCoAReductaseInhibitors:atorvastatincerivastatinlovastatinpravastatinsimvastatinHormone:progesteronetestosteroneImmuneModulators:cyclosporinetacrolimusNSAIDs:diclofenacmeloxicamOralHypoglycemics:glyburideProtonPumpInhibitors:esomeprazoleomeprazolepantoprazoleSteroidhydrocortisoneprednisoneMiscellaneous:bromocriptinebuspironecaffeinechloroquinecisaprideclopidogrelcocainecyclobenzaprinecyclophosphamidedapsonedextromethorphandoxorubicinfluconazoleflutamidehalofantrineirinotecanitraconazolemifepristoneketoconazolepioglitazoneproguanilquininerosiglitazonesalmeterolsildenafilsirolimustamoxifentaxolteniposideticlopidinevincristinewarfarinzaleplonzolpidemzileuton877-431-4362©2006GenelexCorporationHowtoUseThisTableThistableisanabridgedguidetoP-450druginteractionswhichcanbegreatlyexacerbatedbycommongeneticvariations(presenti