姜的药理作用研究进展_朱路

　[]20060303　[](1978),,,。　　　,　(,434000)[]姜具有明显的抗炎、镇吐、抗癌、抗氧化和抗菌作用,延缓神经病变性疾病的发生与发展,对抗体内和体外血管生成以及降血糖、降血脂和降血压作用。[]姜;药理作用[]R285.1[]A　　[]16731409(2006)01032104　　(ZingiberofficinaleRoscoe),,、。、、、,、、。、,,、。。1　抗炎作用1970,(PG)。(NSAIDs),-1(COX-1)-2(COX-2)PG。COX5-,NSAID。,、COX-2[1]。,COX-2iNOS。MurakamiA[2],。ICR5%1。1、(COX-2),2。ELISAIL-1α、IL-1β、TNF-α、PGE2PGF2,。IL-1β、TNF-α、PGE2,,,,。Phan[3]。4,、、,37℃5%CO21h,1hTNF-α,-1(MCP-1)γ-10(IP-10),(RT-PCR)mRNA,ELISAMCP-1IP-10。4,mRNA,,。。COX-2PG,。NF-kappaBCOX-2。kimso[4]6-12-O-+-13NF-kappaB。,COX-2,NF-kappaBDNA,p38,COX-2NF-kappaB。·321·()　2006331JournalofYangtzeUniversity(NatSciEdit)　Mar.2006,Vol.3No.1MedicineV6-NF-kappaB,NF-kappaB,IkappaBalpha,6-p38-NF-kappaB[5]。2　镇吐作用,、[6]、[7],。,,,,。SripramoteM[8],B6,,B6。[9],,,33,,。、,,。。,6,8,10-6-。Abdel-AzizH6,8,10-6-5-HT3[10]。[11],35-HT3,14CN1E-115(5-HT3),,5-HT3。,6,8,10-6-14C5-HT3,6-、8-、10-、6-,5-HT3,6,8,10-6-5-HT3———PM,5-HT3,。。3　抗氧化作用,、。[12～14]。50,2,,-OH。MASU-DA[15]:α,αβ(DP-PH)、AAPH。,,AAPH。,。4　对中枢神经系统的作用,、,。GrzannaR[16]THP-1()、β-()。、、β-,TNF-a、IL-1β、COX-2、MIP-a、MCP-1、IP-10。THP-1,,()。5　对心血管系统的作用[17]6-。6-·322·　:31(VEGF)(bFGF),DNA。,。,6-,。[18],。,、、,、、,,,,6-。VermaSK[19]。Ghayur[20],MCa2+,。6　抗癌作用,。Manju[21]Wistar。,(20mg/mL),,15。,50mg/kg。,,(,-S-,,)(,VitC,VitEVitA),,,。β-,。,β-caspase-3,-7,-9,B,C,C[22]。。Murakami[23],。Takada[24]NF-kap-paB,。7　抗菌作用O'mahonyR[25],,。Mahady[26],6-,8-,10-19,5CagA+,19,MIC=6.25～50μg/mL,19,MIC=0.78～12.5μg/mL,。[27][28]。,,,,,[29]。[][1]GrzannaB,LindmarkL,FrondozaCG.Ginger———anherbalmedicinalproductwithbroadanti-inflammatoryactions[J].JMedFood,2005,8(2):125～132.[2]MurakamiA,HayashiR,TanakaT,etal.Suppressionofdextransodiumsulfate-inducedcolitisinmicebyzerumbone,asubtropicalgingersesquiterpene,andnimesulide:separatelyandincombination[J].BiochemPharmacol,2003,66(7):1253～1261.[3]PhanPV,SohrabiA,PolotskyA,etal.Gingerextractcomponentssuppressinductionofchemokineexpressioninhumansynovio-cytes[J].JAlternComplementMed,2005,11(1):149～154.[4]KimSO,ChunKS,KunduJK,etal.Inhibitoryeffectsof[6]-gingerolonPMA-inducedCOX-2expressionandactivationofNF-kappaBandp38MAPKinmouseskin[J].Biofactors,2004,21(1-4):27～31.[5]KimSO,KunduJK,ShinYK,etal.[6]-GingerolinhibitsCOX-2expressionbyblockingtheactivationofp38MAPkinaseandNF-kappaBinphorbolester-stimulatedmouseskin[J].Oncogene,2005,24(15):2558～2567.·323·20063()　[6]PongrojpawD,ChiamchanyaC.Theefficacyofgingerinpreventionofpost-operativenauseaandvomitingafteroutpatientgynecologicallaparoscopy[J].JMedAssocThai,2003,86(3):244～250.[7]ManusirivithayaS,Sripramote,TangjitgamolS,etal.Antiemeticeffectofgingeringynecologiconcologypatientsreceivingcisplatin[J].IntJGynecolCancer,2004,14(6):1063～1069.[8]SripramoteM,LekhyanandaN.ArandomizedcomparisonofgingerandvitaminB6inthetreatmentofnauseaandvomitingofpregnan-cy[J].JMedAssocThai,2003,86(9):846～853.[9]BooneSA,ShieldsKM.Treatingpregnancy-relatednauseaandvomitingwithginger[J].AnnPharmacother,2005,39(10):1710～1713.[10]Abdel-AzizH,NahrstedtA,PetereitF,etal.H5-HT3receptorblockingactivityofarylalkanesisolatedfromtherhizomeofZingiberofficinale[J].PlantaMed,2005,71(7):609～616.[11]Abdel-AzizH,WindeckT,PlochM,etal.Modeofactionofgingerolsandshogaolson5-HT(3)receptors:Bindingstudies,cationuptakebythereceptorchannelandcontractionofisolatedguinea-pigileum[J].EurJPharmacol,2006,530(1-2):136～143.[12],,.[J].,1997,(4):16～17.[13].[J].,1995,16(12):35～37.[14],,.[J].1999,27(5):84～86.[15]MasudaY,KikuzakiH,HisamotoM,etal.Antioxidantpropertiesofgingerolrelatedcompoundsfromginger[J].Biofactors,2004,21(1-4):293～296.[16]GrzannaR,PhanP,PolotskyA,etal.Gingerextractinhibitsbeta-amyloidpeptide-inducedcytokineandchemokineexpressioninculturedTHP-1monocytes[J].JAlternComplementMed,2004,10(6):1009～1013.[17]KimEC,MinJK,KimTY,etal.[6]-Gingerol,apungentingredientofginger,inhibitsangiogenesisinvitroandinvivo[J].BiochemBiophysResCommun,2005,335(2):300～308.[18]KadnurSV,GoyalRK.BeneficialeffectsofZingiberofficinaleRoscoeonfructoseinducedhyperlipidemiaandhyperinsulinemiainrats[J].IndianJExpBiol,2005,43(12):1161～1164.[19]VermaSK,SinghM,JainP,etal.Protectiveeffectofginger,ZingiberofficinaleRosconexperimentalatherosclerosisinrabbits[J].IndianJExpBiol,2004,42(7):736～738.[20]GhayurMN,GilaniAH,AfridiMB,etal.Cardiovasculareffectsofgingeraqueousextractanditsphenolicconstituentsaremedia-tedthroughmultiplepathways[J].VasculPharmacol,2005,43(4):234～241.[21]ManjuV,NaliniN.Chemopreventiveefficacyofginger,anaturallyoccurringanticarcinogenduringtheinitiation,post-initiationsta-gesof1,2dimethylhydrazine-inducedcoloncancer[J].ClinChimActa,2005,358(1-2):60～7.[22]WangG,LiX,HuangF,etal.Antitumoreffectofbeta-elemeneinnon-small-celllungcancercellsismediatedviainductionofcellcyclearrestandapoptoticcelldeath[J].CellMolLifeSci,2005,62(7-8):881～893.[23]MurakamiA,TanakaT,LeeJY,etal.Zerumbone,asesquiterpeneinsubtropicalginger,suppressesskintumorinitiationandpromotionstagesinICRmice[J].IntJCancer,2004,110(4):481～490.[24]TakadaY,MurakamiA,AggarwalBB.ZerumboneabolishesNF-kappaBandIkappaBalphakinaseactivationleadingtosuppressionofantiapoptoticandmetastaticgeneexpression