氯己定类消毒剂的研究进展

:1001-7658(2010)04-0460-03邱凯(3M中国研发中心,上海200233);;:R187.2:A(chlorhexidine),50!1∀,,,!2,3∀,,,1(),1,6-(-),(-NH-CO-NH-)(=NH),,,11,,,,,,,,,(ChlorhexidineAcetate,CHA);,(Chlorhexidinehydrochloride);,(ChlorhexidineGluconate,CHG),2(20%),(18%)(006%),!4∀,,,221杀菌效果,!5∀,,,,,!6,7∀,,!6∀,,!8,9∀,20g/L,6h!9∀1%CHG,CHG6h20g/L,72h!10∀22杀菌机理,,,,,McLellan!11∀,,,,,23影响因素,1000mg/L,10mg/L,,!2∀,#460#ChineseJournalofDisinfection2010;27(4),,,,,,!12∀3,!13∀,!14~16∀,10,,!12∀,,31醋酸氯己定70!17∀,!18∀90,,,,,!19∀!20∀,,!21∀,,,,,,,,,!19∀,,32葡萄糖酸氯己定,60!22∀1985,!23∀,2002!16∀,1200mg/L,52%,,,,,!24∀,40g/L(Hibiclens)15min,,10g/L33葡萄糖酸氯己定与醋酸氯己定的临床使用比较80,10g/L!25∀,2;,3434葡萄糖酸氯己定与碘伏的临床使用比较!26∀,20g/L70%10g/L30s50,10%,30s40,!27∀,75g/L40g/L!28∀,30s,,3h,,35氯己定消毒剂的临床应用,11-!5∀-10g/L61%!29∀40g/L!30∀40g/L!31∀20g/L!32∀5g/L!5∀3g/L~5g/L!5∀1200mg/L!33∀20g/L!34∀5g/L!5∀2000mg/L!35∀!5∀-5g/L70%!5∀#461#中国消毒学杂志2010年第27卷第4期!1∀DaviesGE,FrancisJ,MartinAR,eta.l1:6-Di-4∃-chlorophenyldiguanidohexane(hibitane);laboratoryinvestigationofanewantibacterialagentofhighpotency[J].Britishjournalofpharmacologyandchemotherapy.1954,9(2):192.!2∀,.[M].:,2004:190.!3∀,.[J].,2008,10(7):44.!4∀ZengP,RaoA,andScottTW.SolubilityPropertiesOfChlorhexidineSalts[J].DrugDevelopmentandIndustrialPharmacy,2009,35(1):172.!5∀.[S].:,2002.!6∀CentersforDiseaseControlandPrevention.GuidelineforHandHygieneinHealth-CareSettings[S].2002:51.!7∀玥,徐冬梅,周丽萍,等.外科手消毒剂的研究进展[J].中,2009,26(1):68.!8∀CharlesEE,GaryRS,JohnsonCP.Comparativeofanewandinnovative2%chlorhexidinegluconate-impregnatedclothwith4%chlorhexidinegluconateastopicalantisepticforpreparationoftheskinpriortosurgery[J].AmericanJournalofInfectionContro.l,2007,35(1):89.!9∀,,.[J].,2007,17(7):789.!10∀WhiteRR,HaysGL,JanerLR.ResidualAntimicrobialActivityAfterCanalIrrigationwithChlorhexidine[J].JournalofEndodontics,1997,23(4):229.!11∀McLellanE,TownsendR,ParsonsHK.EvaluationofChloraPrep(2%chlorhexidinegluconatein70%isopropylalcohol)forskinantisepsisinpreparationforbloodculturecollection[J].JournalofInfection,2008,57(3):459.!12∀,.[J].,1986,11(1):40.!13∀,.[J].,1992,8(1):33.!14∀AliciaJM,TeresaCH,PearsonML,eta.lGuidelineforPreventionofSurgicalSite[J].Infection,Americajounalinfectioncontro,l1999,27(2):97.!15∀PrattRJ,PelloweC,LovedayHP,eta.lTheepicProject:DevelopingNationalEvidence-basedGuidelinesforPreventingHealthcareassociatedInfections[J].JournalofHospitalInfection,2001,47(Suppl):S3.!16∀CentersforDiseaseControlandPrevention.GuidelinesforthePreventionofIntravascularCatheter-RelatedInfections[S].2002:51.!17∀.[J].,1987,15(3):39.!18∀.[J].,1985,5(11):40.!19∀.[J]..1994,13(3):119.!20∀.[J].,1998,30(6):360.!21∀.[J].,2006,13(7):40.!22∀SchiottCR,LoeH,JensenSB,eta.lTheeffectofchlorhexidinemouthrinsesonthehumanoralflora[J].JournalofPeriodontalResearch,1970,5(2):84.!23∀..,1984,7(1):21.!24∀ShippeySH,MalaTK.DesquamatingVaginalMucosaFromChlorhexidineGluconate[J].Obstetrics&Gynecology,2004,103(5):1048.!25∀KnudsenBB,AvnstorpC.Chlorhexidinegluconateandacetateinpatchtesting[J].ContactDermatitis,1991,24(1):45.!26∀AdamsaD,QuayumbM,WorthingtonbT,eta.lEvaluationofa2%chlorhexidinegluconatein70%isopropylalcoholskindisinfectant[J].JournalofHospitalInfection,2005,61(2):287.!27∀FaoagaliJ,FongJ,GeorgeN,eta.lComparisonoftheimmediate,residua,landcumulativeantibacterialeffectsofNovaderm,Novascrub,BetadineSurgicalScrub,Hibiclens,andliquidsoap[J].AmericanJournalofInfectionContro,l1995,23(6):337.!28∀ChaiyakunaprukN,DavidLV,LipskyBA,eta.lVascularCatheterSiteCare:TheClinicalandEconomicBenefitsofChlorhexidineGluconateComparedwithPovidoneIodine[J].ClinicalInfectiousDiseases,2003,37(6)::764.!29∀MulberrryG,SnyderAT,HeilmanJ,eta.lEvaluationofawaterless,scrublesschlorhexidinegluconate/ethanolsurgicalscrubforantimicrobialefficacy[J].AmericanJournalofInfectionContro,l29(6):377.!30∀,,.[J].,2007,17(10):247.!31∀PaulsonDS.Efficacyevaluationofa4%chlorhexidinegluconateasafull-bodyshowerwash[J].AmericanJournalInfecttionContro,l1993,21(4):205.!32∀BleasdaleSC,TrickWE,GonzalezIM,eta.lEffectivenessofChlorhexidineBathingtoReduceCatheter-AssociatedBloodstreamInfectionsinMedicalIntensiveCareUnitPatients[J].ArchivesofInternalMedicine,2007,167(19):2073.!33∀HoustonS,HouglandP,AndersonJ.Effectivenessof0.12%chlorhexidinegluconateoralrinseinreducingprevalenceofnosocomialpneumoniainpatientsundergoingheartsurgery[J].AmericanJournalofCriticalCare,2002,11(6):567.!34∀LeonardoMR,FilhoMT,SilvaLAB,eta.lInVivoAntimicrobialActivityof2%ChlorhexidineUsedasaRootCanalIrrigatingSolution[J].JournalofEndodontics,1999,25(3):167.!35∀BabillSP,TomB,AnneH.Vaginaldisinfectionwithchlorhexidineduringchildbirth[J].InternationalJournalofAntimicrobialAgents,1999,12(2):245.(:2009-11-24)#462#ChineseJournalofDisinfection2010;27(4)