世界健康调查项目中国预调查重测信度分析

*:(GLGLOOSDOOOAS00.999.00):11,200032;21:(1972-),,,,,::1001-0580(2006)03-0282-03:R18113+7:A=*曹阳1,陈洁1,曹建文1,钱军程2:(WHS)Cohen.sKappaWHS,,J01990%80%95%CI(019262,019617)(017742,018178)(016923,017333),WHS,:;(WHS);Tes-tretestreliabilityanalysisonworldhealthsurvey-ChinapilotstudyCAOYang,CHENJie,CAOJianwen,etal.HealthTechnologyAssessmentandResearchCenter,FudanUniversity(Shanghai200032,China)Abstract:ObjectiveToassessthereliabilityofworldhealthsurvey(WHS)questionnairesbeingappliedinaChineseenviron-ment.MethodsCohen.sKappa,concordancecorrelationcoefficientandintraclasscorrelationcoefficientwereusedtocalculatethetest-retestreliabilityofcategorical,rankedandquantitativemeasurements.ANOVAmethodwasusedtocomparethetes-tretestreliabi-litiesofobjectiveitemswithofsubjectiveitems.ResultsHighreliabilitywasfoundinobjectiveitemsandinsel-freliabilitiesofobjec-tiveitems,andtheitemswithaKappalargerthan019inthesetwocategoriesweremorethan90%and80%separately.Theconf-idenceintervalsofreliabilityofobjectiveitems.sel-freportedquestionsandvignettequestionswere(019262,019617),(017742,018178)and(016912,017333)separately,whichshowedastatisticalsignificantdifference.ConclusionWHSquestionnaireshowsahighdependabilityincollectingrealitydata,butisreliabilityneedtobeimprovedinvignettequestions.Keywords:tes-tretestreliability;worldhealthsurvey(HWS);healthmeasurement(worldhealthsurvey,WHS)(WHO),WHO,WHS1111对象WHS10400010%,2,2,WHS,WHS2,,,,;,,,(vignette)3112分析方法WHS(cate-goricalmeasurement)(rankedmeasurement)(quantitativemeasurement)3Cohen.sKappaJ,11,22:J=Po-Pe1-Pe(1)Po2,Pe/(chance)02(concor-dancecorrelationcoefficient,CCC)13~52(intraclasscorrelationcoefficient,ICC)16,72CCC:CCC=2R12R21+R22+(L1-L2)2(2)2L1L22,R1R2R122ICC:ICC=R2AR2A+R2B+R2E(3)3,ijYij,Yij=L+Ai+Bj+Eij,L,Ai,Bj;AiN(0,R),BjN(0,RB),EijN(0,RE),182:R=6mi=1RiS2Ri6mi=11S2Ri(4)4RiiKappaCCC,S2Ri28220063223ChinJPublicHealthMar2006Vol.22No.3113统计分析SPSS1110Stata8122211客观性条目的重测信度WHS1500,600,,,J01990121%:,J01989179%J018,//0/40,WHS212主观性条目的重测信度,,,WHS,,,;,95%CI(019262,019617)(017742,018178)(016923,017333),(F=1531008,P01001),,,018214,017946017423,95%CI(018063,018364)(017714,018178)(017149,017696),(F=231174,P01001)WHS;,,(F=013701,P=015623),11080,50%45%0176017,017252(10),,;,(1)3,Spearman,2/02,,J2,,245b,r1P016766016700017620170600158080100001667801594501097017311016183010010168130160900103601718001689001428017065017102019040167590164760159201695401639901000A01647801605801000B01691401600401003016831016031010000173870182160110701749201799901252016734016352015810163890170470103401672601676301956017310016543013270171540157020120701695301674901641016762018183010170169570171980120601769401725401026WHS24,50%019,3715%019017,1215%017,WHS,,,,,,,(cross-cultural),,,112KvalsethTO.Weightedspecific-categorykappameasureofinterobserveragreement[J].PsycholRep,2003,93(3Pt2):1283-1290.122MassonLF,McNeillG,TomanyJO,etal.Statisticalapproachesforas-sessingtherelativevalidityofafood-frequencyquestionnaire:useofcor-relationcoefficientsandthekappastatistic[J].PublicHealthNutr,28320063223ChinJPublicHealthMar2006Vol.22No.32003,6(3):313-321.132CarrascoJL,JoverL.Estimatingthegeneralizedconcordancecorrelationcoefficientthroughvariancecomponents[J].Biometrics,2003,59(4):849-858.142BarnhartHX,HaberM,SongJ.Overallconcordancecorrelationcoeff-icientforevaluatingagreementcorrelationcoefficientforevaluatingagree-mantamongmultipleobservers[J].Biometrics,2002,58(4):1020-1027.152KingTS,ChinchilliVM.Ageneralizedconcordancecorrelationcoeff-icientforcontinuousandcategoricalcoefficientforcontinuousandcate-goricaldata[J].StatMed,2001,20(14):2131-2147.162CommengesD,JacqminH.Theintraclasscorrelationcoefficient:distribu-tion-freedefinitionandtest[J].Biometrics,1994,50(2):517-526.172ParkHM,JungHW.Evaluatinginterrateragreementwithintraclasscor-relationcoefficientinspice-basedsoftwareprocessassessment[C].ThirdInternationalConferenceOnQualitySoftware,2003:308-314.182FleissJL.Statisticalmethodsforratesandproportions[M].NewYork:JohnWiley&SonsInc,1981:121-134.:2005-06-13()*:(5004774):,510515:(1979-),,,,::1001-0580(2006)03-0284-02:R13513:A=CD14*张培,陈雪梅,罗炳德,谭庆,邹飞,万为人,郭进强:,CD14(5d60mg/kg),PCR(RT-PCR)CD14mRNA,(ELISA)A(TNF-A),CD14mRNATNF-A(P0101),CD14mRNA,TNF-ACD14,TNF-A,:;CD14;;EffectsofartesunateonCD14inLPSsignaltransductionpathwayZHANGPei,CHENXuemei,LUOBingde,etal.DepartmentofThermalEnvironmentMedicine,NanFangMedicalUniversity(Guangzhou510515,China)Abstract:ObjectiveTodiscusstheeffectsofartesunateonCD14expressioninLPSsignaltransductionpathwaywhileheat-strokeendotoxemia.MethodsKun-mingmicewererandomlydividedintonormaltemperaturegroup,hyperthermiagroup,NSgroupandartesunategroup(5dayscontinuousperitonealinjectionartesunatebyadoseof60mg/kg).ThenCD14mRNAexpressionsofper-itonealmacrophagesineachgroupmiceofnormaltemperatureconditionandheatexposurewerequantitatedbyreversetranscription-polymerasechainreaction(RT-PCR).AndcontentsofTNF-AinplasmaweremeasuredbyEnzyme-linkedimmunoadsorbentassay(ELISA).ResultsComparedwithnormaltemperaturegroup,thelevelo