原发性青光眼流行病学研究进展

··1210100592010017、。、[e-mail]2011-11-292012-03-08ProgressinepidemiologicalstudiesofprimaryglaucomainChinaJunWang1WeiCui21OphthalmologyMajorGraduateSchoolofInnerMongoliaMedicalCollegeHohhot010059InnerMongoliaAutonomousRegionChina2DepartmentofOphthalmologyInnerMongoliaPeople'sHospitalHohhot010017InnerMongoliaAutonomousRegionChinaCorrespondencetoWeiCui．DepartmentofOphthalmologyInnerMongoliaPeople'sHospit[e-mail]2011-11-29Accepted2012-03-08AbstractGlaucomaistheprimarycauseofinreversibleblindness．Asthechangeofsocietyeconomyandenvironmentandtheimprovementofthewaysofdiagnosisandtreatmentofglaucomatheepidemiologicalfeatureisalsochangingincessantly．Sincedifferentdiagnosticstandardandclassificationsystemofglaucomaleadtodifferentsurveyresultofepidemiologyandtheepidemiologicalfeaturegivesdirectiontotheclinicalinterveningmeasurethesituationofglaucomaepidemiologyisofgreatimportancetoprophylaxisandtreatmentofglaucoma．ThisthesisgivesanoverviewoftheprogressinresearchfieldofprimaryglaucomaepidemiologyinChina．KEYWORDSepidemiologyglaucomaprevalencerateriskfactorsWangJCuiW．ProgressinepidemiologicalstudiesofprimaryglaucomainChina．GuojiYankeZazhiIntEyeSci2012124667-670。、、。。。。DOI10．3969/j．issn．1672-5123．2012．04．20．．2012124667-6700。。Quigley1202020207960600。、、。1、、。。primaryangleclosureglaucomaPACG1987“”5《》PACGPACG、、、。“”internationalsocietyofgeographicalandepidemiologicalophthalmologyISGEOPACG。PACG321primaryangleclosuresuspectPACS。2primaryangleclosurePACPACS、、、PAC。PAC。3PACGPACPACG。ISGEO1ISGEOglaucomatousopticneuropathyGONPACG。2ISGEOPACG766IntEyeSciV[e-mail]。3ISGEOPACPACPACG。POAG。331。2。3。retinalnervefiberlayerRNFLPOAG4。POAG。31、。2。3。4。5。。POAG。POAG。22．12．1．1PACG199655555PACG1．66%198550PACG1．99%61997750PACG1．0%。20038、38500≥502125PACG1.63%。2006950PACG1．5%。PACG。PACG1、、。2。3。2．1．2POAGPOAGPOAG、。1985104722151085110414POAG0．11%19965＞504888POAG0．29%POAG11。198712POAG0．07%。20011353404451POAG1．97%2．07%POAG1．04%1．42%。1504POAG2．1%14。200915405158579POAG1．73%。POAGPACG。POAG1、、2。2．22．2．1PACG2．2．1．11101985PACG1294058±10。145089．68%。PACG。1695%50。17。21245310．13%0．47%。7199750PACG0．8%1．2%。13PACGPACG1．7%0．8%。PACGPACG。3PACG。199018、、20、20PACG0．08%400．15%0．62%1．37%。199819PACG3．02。201020PACG、、PACG。2．2．1．2PACG、、、[e-mail]。。17PACGPACG。21APACG1．780±0．328mm2．067±0．261mm2．457±0．296mmPACG。PACG。222AlconA/BA10．84±0．428mm11．64±0．513mm21．85±1．019mm23．15±16．215mm。-。321UBMAPACG582±208μm650±125μmP＜0．05。PACG。2．2．1．3PACGPACG。23PACG7．10%2．33%。300．96%24P＜0．001。2．2．1．42515682．1%、。2613851A、AATHCHTH+CHP＜0.05P＜0．01EPQNLP＜0．05P＜0．01。AA。2．2．2POAG2．2．2．1271995/2000POAG107POAG149logisticPOAG。POAG。1mmHgPOAG12.5%～52．9%。2．2．2．2。285050、、C/D、1502550．0%2383503570．0%2550．0%1734．0%1734．0%76．0%。。2．2．2．329182355219163。210．4%。304%～11%3。311692008-10/2010-1012060、60A、A、2h3．3%A13．3%AP＜0．01。POAG。。。2．2．2．432R2038POAGPOAG、、、、EAIKP＜0．050．01。POAGEAIPOAG。2．2．2．5highmyopiaHM。33HMPOAG1．20%0．12%。3478．72%62．22%P=0．0140。966IntEyeSciV[e-mail]35、。HM。2．2．2．62009405158POAG1．73%15。362008501743POAG0．40%200914419140POAG0．26%37。POAGPOAGPOAG。2．2．2．738422∶=1∶1。POAGPOAGPOAGPOAGMYOC/TIGROPTNWDR36CYP1B1POAG39POAGMYOC/TIGR2%～4%POAGMYOC/TIGRPOAGMYOC/TIGR、40。3。POAG。。。。1QuigleyHABromanAT．Thenumberofpeoplewithglaucomaworld-widein2010and2020．BrJOphthalmol2006903262-2692．ISGEO．200848181073．．2010315682-6844．．200682-835．50．2002386335-3396．．2005256573-5757．．2000213212-2148．．2005551037-10429．50．2007209774-77610．．1989252115-11911．．200618471-7512．．1995312149-15113．．20044011726-73214HeMFosterPJGeJetal．PrevalenceandclinicalcharacteristicsofglaucomainadultChineseapopulation-basedstudyinLiwanDistrictGuangzhou．InvestOphthalmolVisSci20064772782-278815．．2010427817-81916．5．201143121-2317LeskeMCHusseinMBengtssonBetal．Factorsforglaucomaprogressionandtheeffectoftreatmenttheearlymanifestglaucomatrial．ArchOphthalmol2003121148-5618．．199026247-5019．．1998102269-27120．．2010287454-45821．．1998345365-36822．．2002204284-28523．．198521295-10124．40．2005238782-78425．．199819158-5926．A．200133174-17627．．2002234293-29628．．20039320229．2．200830121941-194230．．1．200450131．．201122493-9432．．200010293-9433．．1986226349-35234．．2010482523-2435．．20094229-3236．50．20093222079-208137．．20102119169-17338．．2010501899-10039AllinghamRRLiuYRheeDJ．Thegeneticsofprimaryopen-angleglaucomaareview．ExpEyeRes20098811837-84440．MYOC/TIGR．[e-mail]