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29SpecialForum25mIU/L(subclinicalhypothyroidismSCH)(TT4FT4)(TSH)1%10%2%[1]1/3SCHTSHTSH[2]SCHTSHSCHTSH(TSHR)TSHSCH[2]1SCH3[3]TSHRTSHTSHTSH[4]2Pharmaceuticaltreatmentofsubclinicalhypothyroidisminchildren30SpecialForumSTSH[5]288%TSH2[6]2011Cerbone[7]36TSH4.510mIU/L3BMITSHT46T4T4TSH20%[8]550%[9]TSH9mIU/LFT40.92.3ng/dl[10]TSH925mIU/LTSHFT4TSH25mIU/L1015ug/kg324TSHFT4612632331612FT41/20.82.3ng/dl1.42.3ng/dl12TT41016ug/dl21/2TSH5mIU/L0.52.0mIU/L1412[11][12]20%50%48[13]TSH25mIU/L34SpecialForumSTG(verylow-densitylipoproteincholesterolVLDL-C)VLDL-CTG[9]LT4LDL-C[10][1]BauerDC,EttingerB,BrownerWS.Thyroidfunctionsandserumlipidsinolderwomen:apopulation-basedstudy[J].AmJMed,1998,104(6):546-551.[2]TagamiT,KimuraH,OhtaniS,etal.Multi-centerstudyontheprevalenceofhypothyroidisminpatientswithhypercholesterolemia[J].EndocrJ,2011,58(6):449-557.[3]KrysiakR,OkopienB.Theeffectofsimvastatinonlymphocytesecretoryfunctioninpatientswithimpairedfastingglucose[J].JCardiovascPharmacol,2010,56:491-497.[4]KiernanTJ,RochfordM,McDermottJH.Simvastatininducedrhabdomyolysisandanimportantclinicallinkwithhypothyroidism[J].IntJCardiol,2007,119,374-376.[5]RotondiM,denElzenWP,BauerDC,etal.Subclinicalhypothyroidismandtheriskofcoronaryheartdisease[J].JAmMedAssoc,2010,304:1365-1374.[6]LadensonPW,KristensenJD,RidgwayEC,etal.Useofthethyroidhormoneanalogueeprotiromeinstatin-treateddyslipidemia[J].NEnglJMed,2010,362:906-916.[7]WatanabeH,HoutenSM,MatakiC,etal.Bileacidsinduceenergyexpenditurebypromotingintracellularthyroidhormoneactivation[J].Nature,2006,439:484-489.[8]InsullWJ.Clinicalutilityofbileacidsequestrantsinthetreatmentofdyslipidemia:ascientifcreview[J].SouthMedJ,2006,99:257-273.[9].(1)[M].:,2010.[10]DuntasL,KolovouG.Optionsforthetreatmentofhyperlipidemiaintype2diabetesmellitusandhypothyroidism:loweringthecardiovascularrisk[J].FutureCardiol,2011,7(2):137-144.2012-2-202012-3-15[1]RapaA,MonzaniA,MoiaS,etal.Subclinicalhypothyroidisminchildrenandadolescents:awiderangeofclinical,biochemical,andgeneticfactorsinvolved[J].JClinEndocrinolMetab,2009,94(7)2414-2420.[2]KaplowitzPB.Subclinicalhypothyroidisminchildren:normalvariationorsignofafailingthyroidgland[J]?IntJPediatrEndocrinol,2010:1-8.[3]RagoT,ChiovatoL,GrassoL,etal.Thyroidultrasonographyasatoolfordetectingthyroidautoimmunediseasesandpredictingthyroiddysfunctioninapparentlyhealthysubjects[J].JEndocrinolInvest,2001,24:763-769.[4]RapaA,MonzaniA,MoiaS,etal.Subclinicalhypothyroidisminchildrenandadolescents:awiderangeofclinical,biochemical,andgeneticfactorsinvolved[J].JClinEndocrinolMetab,2009,94(7):2414-2420.[5]O'GradyMJ,CodyD.Subclinicalhypothyroidisminchildhood[J].ArchDisChild,2011,96(3):280-284.[6]DeLucaF,WasniewskaM,ZirilliG,etal.Attheendofatwo-yearfollow-upelevatedTSHlevelsnormalizeorremainunchangedinmostthechildrenwithsubclinicalhypothyroidism[J].ItalJPediatr,2010,30(36):11.[7]CerboneM,BravaccioC,CapalboD,etal.Lineargrowthaintellectualoutcomeinchildrenwithlong-termidiopaticsubclinicalhypothyroidism[J].EurJEndocrinol,2011,164(4):591-597.[8]FavaA,OliverioR,GiulianoS,etal.Clinicalevolutionofautoimmunethyroiditisinchildrenandadolescents[J].Thyroid,2009,19(4):361-367.[9]MarkovicS,KosticG,IqrutinovicZ,etal.Hashimoto'sthyroiditisinchildrenandadolescents[J].SrpArhCelokLek,2008,136(5-6):262-266.[10]LafranchiSH.Approachtothediagnosisandtreatmentofneonatalhypothyroidism[J].JclinEndocrinolMetab,2011,96(10):2959-2967.[11],,,.[J].,2006,41(3):338-340.[12]JensovskyJ,RuzickaE,SpackovaN,etal.Changesofeventrelatedpotentialandcognitiveprocessesinpatientswithsubclinicalhypothyroidismafterthyroxinetreatment[J].EndocrRegul,2002,36(3):115-122.[13]CalaciuraF,MottaRM,MiscioG,etal.Subclinicalhypothyroidisminearlychildhood:afrequentoutcomeoftransientneonatalhyperthyrotropinemia[J].JClinEndocrinolMetab,2002,87(7):3209-3214.2012-3-202012-4-8