急性白血病长期生存患者生命质量调查

:100426194(2001)03205202132031,1,2,1(11,200040;21,200032):(AL)198411111994112131291379595FACT2G,85,6050%,1216%,,,:;;:R73231:R733171:AAStudyontheQualityofLife(QOL)inLong-termSurvivorswithAcuteLeukemiaWANGXiao2qin,etal;DepartmentofClinicalEpidemiology,FudanUniversityMedicalCollege,Shanghai200040,ChinaAbstract:ObjectiveToassessthequalityoflife(QOL)inlong2termsurvivorswithAL.MethodsTherewere95long2termsurvivorswithALdrawnfrom29hospitalsinShanghaiduring1984to1994.QuestionnaireFACT2Gwascompletedinordertoas2sesstheQOLforlong2termsurvivorswithAL.ResultsandConclusionQuestionnaireswerefilledinby95long2termsurvivorswithAL.ThemajorityofsurvivorshadnormalQOL.TheaverageQOLscorewas85.Patients,beingilliterateandagedover60yearsold,hadhigherQOLscore.About50%patientsreturnedtofull2timejoborschool.12.6%patientshadsecondarydiseasesduetochemotherapy.Inmarriedpatients,nearlyhalfofthepatientswerenotsatisfiedwithsexuallife.Therefore,thepreventionofse2condarydiseasesandtheprotectionofsexualfunctionmustbetakenseriouslyduringchemotherapy.Themostworryingproblemswererelapseandtreatmentexpenses.So,theestablishmentofmedicineinsurancesystemwasveryimportantforthesepatients.Keywords:Acuteleukemia;Long2termsurvival;Qualityoflife(QOL),,,,AL5QOL1111198419945AL95,95AML53(5518%),ALL42(4412%),M11,M210,M327,M46,M57,M62,L120,L220,L32:2001201212;:2001203215:(19682),,,,,112CellaFACT2G1,,AL,,30AL,CronbachA,012,A016,11395AL,114Stata,t,2211CronbachA,CronbachA0188,CronbachA0190,ö0177,0177,0168,01662125,31220011095©1995-2004TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.2139532(1071),48,4745(4714%),,8(814%),27(2814%),15(1518%)2214QOL95QOL85,(014)(60)QOL,(1)QOL82,QOL871QOL()(%)QOL(xs)P01422(23.2)87.022.8153938(40.0)83.618.00.05405926(27.4)80.017.9609(9.4)98.54.00215QOLQOL,5100QOL(2)2QOL(%)QOL(xs)P5(5.3)100.00.026(27.4)87.620.532(33.7)83.221.00.05()20(21.0)79.215.112(12.6)86.710.3216,,,12,2,3,3,1,1,2217ö60%,,46,5413%,,4113%2189618%,,90%21960%,,,:43(4513%),20(2110%),5(513%)2110,,90%3,,,QOL,,QOL,QOL:QOL,QOL,CellaFACT2G,,,,955,QOL,,,,,,,QOL85Stalfelt2Yau3ALCR1,,,12,,,,,,,,,,QOL,QOL,QOL,QOL,5412ChinJContrChronNon2communDis,Octaber2001,Vol9,No.5©1995-2004TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.100,,2,,4113%,Greenberg33%4,:,,,;,,21QOL,QOL,,51216%,,,,AL,,:1CellaDF,TulskyDS,GrayG,etal.Thefunctionalassessmentofcancertherapyscale:developmentandvalidationofthegen2eralmeasureJ.JClinOncol,1993,11(3)570.2StalfeltAM.QualityoflifeofpatientswithacutemyeloidleukaemiaJ.LeukemiaRes,1994,18(4)2572267.3YauE,RohatinerAZS,ListerTA,etal.Longtermprognosisandqualityoflifefollowingintensivecareforlife2threateningcomplicationsofhaematologicalmalignancyJ.BrJCancer,1991,64938.4GreenbergDB,KornblithAB,HerndonJE,etal.QualityoflifeforadultleukemiasurvivorstreatedonclinicaltrialsofCancerandleukemiaGroupBduringtheperiod197121988:predictorsforlaterpsychologicdistressJ.Cancer,1997,80(10)193621944.5,,,1J1,1994,15(12)6382640.(202)TCLDL2CDBP,TGHDL2C6,,TGTCHDL2CLDL2C,TGTC,TC,,,,,Bonaa,,,,BMI,,,TG,HDL2C,TG,LDL2C,HDL2CTG,HDL2C,,1103mmolöL5,(P0101),TGLDL,TGHDLLDL,,TGLDL,LDL7,,,,,:1,,,1J1,1997,25(3)169217512,1A1:,1M1:,1997,6627213KestelootH,GeboerJ,JoossensTV.Onthewithinpopulationrelationshipbetweennutritionandserumlipids,theBIRHStudyJ.EurHeartJ,1989,10,196.4,,,1J11990,4200220515,,,1J1,1991,5317231916BonaaKH,ThelleDS.AssociationbetweenbloodpressureandserumlipidsinapopulationJ.TheTromsStudyCirculation,1991,831305.7AustinMA,KingMC.VanizanKM,etal.Atherogeniclipopro2teinphenotype.AproposedgeneticMarkerforcoronaryheartdiseaseJ.Circulation,1990,82495.51220011095©1995-2004TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.