常见温度敏感型原位凝胶载体的研究进展

20100903004“”20[e-mail]*[e-mail]11121*1.1007002.330006。、、。407N-R283.6A1005-9903201102-0252-05ResearchProgressionofSeveralCommonTemperature-sensitiveinSituGelCarriersXUJia-yin1YANGHong-jun1XIONGXin12CHENYan-jun1*1.InstituteofChineseMedicineTraditionalChineseAcademyofSciencesBeijing100700China2.JiangxiUniversityofTraditionalChineseMedicineNanchang330006ChinaAbstractTemperature-sensitiveinsitugelisonekindofmacromolecularpolymergelwhichissensitivetotemperaturechange.Itisoneofnewmaterialswhichresponsetoenvironmentvariationandiswidelyusedinintelligentcarriermaterialofdrugdeliverysystem.Thispaperreviewstheaspectsofseveralcommontemperature-sensitiveinsitugelsincludingthecharacteristicsformularatioandclinicalapplicationandprovidesscientificevidenceforfurtherstudyingthissortofmacromolecularpolymerandalsoinvestigatetheirresearchprospects.Keywordstemperature-sensitiveinsitugelspoloxamer407chitosanpolyN-isopropylacrylamidethermosensitiveinsitugelLCSTLCST3。、、。1①2。②2N-、-、-。③、、。3。·252·17220111ChineseJournalofExperimentalTraditionalMedicalFormulaeVol.17No.2Jan.2011407P407、、、N-PNIPAAm32℃。/PVAPVA1、P407P1882。3、N-。1.1poloxamerPEOPPOPEO-PPO-PEO。PPOPPO、PEG。2。P407PEO-PPO-PEO、3。P407P407、、、P407、4。PP0PEO。P188P4071。1P407P4072000525%P4076P4077P4078P4079P40710P40711P407+20%P40712P407+P18823%P407+2%P188－218.2%P407+8.8%P1881320%P407+10%P18814P407+P188+15%P407+15%P188+0.6%1523%P407+7%P188+1.5%MC+10%、1616%P407+6%P188+0.2%HPMC+0.5%+4%g·mL－133℃Higuchi17P407+P407+－、18·352·1P407+P407-g-35.1℃19P407+20-P40721－P407+18%P407+0.3%-32.6℃22P407+P407+、、23P407+P407+P40724P407+P407+P40724P407+P407+24P407++15%P407+17%P188+0.01%+1.6%+2.5%、25P407+P407+P40726P407++P407++0.1%5-27P407+20%P407+P40728P407+P407+P407291.2。①②pHpH6.2pH6.2③pH。。2。1.3N-N-PNIPAAm32℃。PNIPAAmLCST。。38N-。39N-/N-38℃。40N-/、。WuMinghong41N-。42/N-pH/LCST。·452·17220111ChineseJournalofExperimentalTraditionalMedicalFormulaeVol.17No.2Jan.20112+30++BMSCBMSC31++32+N-PNIPAM-COOH30℃1+N-N-NN-pH33+1HBC1+－34/++、35+2000200037℃36+P407+P188P407P18815%15%00.1%～0.6%372LCST。①②-、③④、⑤。、、、、、。。、、、、。ZakiNM7P40713。①②③④。①②③④9。3。、。LCST43。·552·。1.J.2008202/3239.2.J.200918560.3.407J.2009173231.4.J.200931284.5CafaggiSRussoECaviglioliGetal.Poloxamer407asasolubilisingagentfortolfenamicacidandasabaseforagelformulationJ.EurJPharmSci2008351/219.6VeyriesMLCouarrazeGGeigerSetal.ControlledreleaseofvancomycinfromPoloxamer407gelsJ.IntJPharm19991922183.7ZakiNMAwadGAMortadaNDetal.EnhancedbioavailabilityofmetoclopramideHClbyintranasaladministrationofamucoadhesiveinsitugelwithmodulatedrheologicalandmucociliarytransportpropertiesJ.EurJPharmSci2007324/5296.8.J.2006373456.9.407J.2009188699.10.J.2006252107.11.J.2007391074.12MorishitaMBarichelloJMTakayamaKetal.PluronicF-127gelsincorporatinghighlypurifiedunsaturatedfattyacidsforbuccaldeliveryofinsulinJ.IntJPharm20012122289.13.J.2006154280.14.J.2008336628.15RyuJMChungSJLeeMHetal.IncreasedbioavailabilityofpropranololinratsbyretainingthermallygellingliquidsuppositoriesintherectumJ.JControlRelease1999592163.16ElHadySSAMortadaNDAwadGASetal.DevelopmentofinsitugellingandmucoadhesivemebeverinehydrochloridesolutionforrectaladministrationJ.SaudiPharmJ2003114159.17.J.2009341933.18.J.200521126.19MaWDXuHWangCetal.PluronicF127-g-polyacrylicacidcopolymersasinsitugellingvehicleforophthalmicdrugdeliverysystemJ.IntJPharm20083501/2247.20.J.20081191025.21.-PluronicF127J.2007243129.22.-J.2009264249.23.J.200918131237.24.J.200716151195.25JingJXPrabagarBalakrishnan.Rheologicalcharacterizationandinvivoevaluationofthermosensitivepoloxamer-basedhydrogelforintramuscularinjectionofpiroxicamJ.InterJPharm20103951/2317.26TofeeqUrRehmanStaffanTavelinGerhardGrbner.EffectofDMSOonmicellizationgelationanddrugreleaseprofileofpoloxamer407originalresearcharticleJ.InterJPharm20103941/292.27ChungTze-WenLinShyr-YiLiuDer-Zenetal.Sustainedreleaseof5-FUfromPoloxamergelsinterpenetratedbycrosslinkingchitosannetworkJ.InterJPharm20093821/239.28LiuYZhuYYWeiGetal.Effectofcarrageenanonpoloxamer-basedinsitugelforvaginaluseImprovedinvitroandinvivosustained-releasepropertiesJ.EurJPharmSci20093/4306.29.D.2009.·652·17220111ChineseJournalofExperimentalTraditionalMedicalFormulaeVol.17No.2Jan.201130AgrawalAKGuptaPNKhannaAetal.DevelopmentandcharacterizationofinsitugelsystemfornasalinsulindeliveryJ.Pharmazie2010653188.31YanJYangLWangGetal.Biocompatibilityevaluationofchitosan-basedinjectablehydrogelsfortheculturingmicemesenchymalstemcellsinvitroJ.JBiomaterAppl2010247625.32TangYDuYLiYetal.Athermosensitivechitosan/polyvinylalcoholhydrogelcontaininghydroxyapatiteforproteindeliveryJ.JBiomedMaterResA2009914953.33.PNIPAM/CSJ.2009212164.34.-J.2009282300.35./J.2006466843.36.J.2007345535.37.J.200716134.38./N-J.2009454523.39.J.20081261157.40.N-/J.2007238245.41WuMHBaoBRChenJetal.PreparationofthermosensitivehydrogelPP-g-NIPAAmwithonoffswitchingforcontrolledreleaseofdrugsJ.RadPhysChem199956341.42.pH/J.2008245377.43.M.2005.·752·