您好,欢迎访问三七文档
当前位置:首页 > 商业/管理/HR > 人事档案/员工关系 > 类风湿关节炎相关机制研究进展
91294.[2].[J].,2002,40(2):1202121.[3]HiroJ,HibiS,AndohT,etal.Highlevelsofcirculatinginterleukin24aninterleukin210inKawasakidisease[J].IntArchAllergyImmunol,1997,112(2):1522156.[4],,,.Th1/Th2[J].,2002,40(2):75277.[5]VagliasindiC,SpinoziF,SensiL,etal.SolubleCD30serumantigeninKawasakidisease[J].ActaPadiatr,1997,86(4):3172318.[6]HorieR,WatanabeT.CD30:expressionandfunctioninhealthanddis2ease[J].SeminImmunol,1998,10(6):4572470.[7],,,.[J].,2002,40(2):1082109.[8].[J].,2001,16(11):6432644.[9]RowleyAH,ShulmanST.Kawasakidisease[A].BehrmanRE,Klieg2manRM,ArvinAM,Eds.Nelsontextbookofpediatrics[M].Philadei2phia:Saunders,2000,7252727.[10].[J].,2002,40(2):65267.[11]NohGW,LeeWG,LeeW,etal.Effectsofintravenousimmunoglobulinonplasmainterluekin210levelsinKawasakidisease[J].ImmunolLett,1998,62(1):19224.[12]KatoH,IchinoseE,KawasakiT.MyocardialInfarctioninKawasakidis2ease:clinicalanalysesof195cases[J].JPediatr,1986,108(11):9232927.:2002205218:2003206221(,400038):;;:R593.22:A:100622084(2003)1020619203(RA),,,,,TB,,,(CD),,Th1PTh21,T,,1.1IL21TNF2IL21TNF2,,RA,,,,[1]Arend,RA,IL21,IL21[2]1.2IL215IL217,IL215,IL22T,TNF2RuchatzIL215DBA,IL215RDBARA,IL215RRAT,IL215R[3]Ziclkowka,RAIL215IL217IL217:IL26IL28GM2CSFPGE2IL215IL217,,IL215,A,RAIL217[4]1.3IL26IL26,IL21TNF[5]FeldmannRAA,IL26IL22[6]IL26,IgGRFIgG,IL26RAMasahikoIL26,[7],IL261.4IL210IL210,IL210PGE2,,IL210PIL21ra,RA,IL210[8](MTX)RA,Rudwaleit,TTNF2IL210[9],IL210RA2mRNA(calpain)(calpastatin)mRNARAcalpastatin,calpaincalpastatinRARAcalpainmRNAcalpastatin,calpainRA(OA)calpastatinC2:calpaincalpastatinRA;RAcalpastatin,9162003910MedicalRecapitulate2003,Vol.9,No.10calpastatinRA[10]3Th1PTh2Th1PTh2,RA,RATh1Th1,Th1PTh2RA,Th1[11]T,B721B722,Th1PTh2,B721T,Th0Th1,B722Th2,B7CD28PCTLA24T,CTLA24IgIL22,RA[12]4CD4.1CD3BergRATCD3,RATCD3CD3,T,TTCR[13]4.2CD30GerlisCD30RA,CD+30TsCD30RA,RAsCD30CD30mRNACD30CD+30TRA,CD+30TIFN2IL24,CD30TIL24,CD+30TIL210,CD+30[14]4.3CD49PCD292CD106RAB,HayashidaBRAa(stromalcellline,SCL),Bcl22,BRASCLSCLB,RASCLRASCL,Bcl2xlB,Bcl22B,CD49PCD292CD106,Bcl2xlB,RASCLB[15]4.4VCAMRA,,VCAMTokuhiraVACM21,VLA24sVCAM,sVCAMVLA24RA,VCAM21,sVCAMRA[16]5RA3RA,RARA,(RF),,Th1Th2,ThIL22,NKRA6RARA2,126bp,122bp,RA,[17]:[1]DinarelloCA.Proinflammatorycytokines[J].Chest,2000,118(2):5032508.[2]ArendW.Cytokineimbalanceinthepathogenesisofrheumatoidarthri2tis:theroleofinterleukin21receptorantagonist[J].ArthritisRhrum,2001,30[5Suppl2]:126.[3]RuchatzH,LeungBP,WeiXQ,etal.SolubleIL215receptoralpha2chainadministrationpreventsmurinecollagen2inducedarthritis:aroleforIL215indevelopmentofantigen2inducedimmunopathology[J].JImmunol,1998,160(11):565425660.[4]ZiclkowkaM,KocA,LuszczykiewiczG,etal.HighlevelsofIL217inrheumatoidarthritispatients:IL215triggersinvitroIL217productionviacyclosporinA2sensitivemechanism[J].Immunology,2000,164(5):42255.[5]GuernePA.SynoviunasasourceofIL26invitrocontributiontolocalandsystemicmanifestationofarthritis[J].JClinInvest,1989,83:585.[6]FeldmannM,MainiRN.Theroleofcytokinesinthepathogenesisofrheumatoidarthritis[J].RheumatolOxford,1999,38[Supple2]:327.[7]MasahikoM,IkutaM,KoishiharaY.Interleukin6inhibitsdelayed2typehypersensitivityandthedevelopmentofadjuvantarthritis[J].EurJIm2munol,1991,21(10):232722331.[8]VoulgariPV,KoliosG,PapadopoulosGK,etal.Roleofcytokinesinthepathogenesisofanemiaofchronicdiseaseinrheumatoidarthritis[J].ClinImmunol,1999,92(2):1532160.[9]RudwaleitM,YinZ,SiegertS,etal.ResponsetomethotrexateinearlyrheumatoidarthritisisassociatedwithadecreaseofTcellderivedtu2mournecrosisfactoralpha,increaseofinterleukin10,andpredictedbytheinitialconcentrationofinterleukin4[J].AnnRheumDis,2000,59(4):3112314.[10],,,.mRNA[J].,2000,4(6):3402343.[11],.Th1PTh2[J].,2000,16(2):1192122.[12]ShimoyamaY,NagafuchiH,SuzukiN.SynoviuminfiltratingTcellsin2duceexcessivesynovialcellfunctionthroughCD28PB7pathwayinpa2tientswithrheumatoidarthritis[J].Rheumatol,1999,26(10):209422101.[13]BergL,RonnelidJ,KlareskogL.Down2regulationoftheTcellreceptorCD3zetachaininrheumatoidarthritis(RA)anditsinfluenceonTcellresponsiveness[J].Immunology,2000,120(1):1742182.[14]GerliR,PitzalisC,BistoniO,etal.CD+30Tcellsinrheumatoidsynovi2tis:mechanismsofrecruitmentandfunctionalrole[J].Immunology,2000,164(8):439924407.[15]HayashidaK,ShimaokaY,OchiT,etal.Rheumatoidarthritissynovialstromalcellsinhibitapoptosisandup2regulateBcl2xLexpressionbyBcellsinaCD49PCD292CD1062dependentmechanism[J].Immunology,2000,164(2):111021116.0262003910MedicalRecapitulate2003,Vol.9,No.10[16]TokuhiraM,HosakaS,VolinV,etal.Solublevascularcelladhesionmolecule1mediationofmonocytechemotaxisinrheumatoidarthritis[J].ArthritisRheum,2000,43(5):112221133.[17]KhaniHA,LacailleD,HoarD,etal.Associationbetweendinucleotiderepeatinnon2codingregionofinterferon2gammageneandsusceptibilityto,andseverityof,rheumatoidarthritis[J].Lancet,2000,356(9232):8202825.:2002209214:2003206202(),()(,830001):;;;:R593.241;R751:A:100622084(2003)10206212022080(AECA),AECA,,AECA,,AECA,,1AECAAECA(VEC)[1],IgGIgMIgA,IgG2AECA[2]1994,DelPapa[3]AECASDS2PAGE10(WG)12SLEAECA,WG5(1801551256825ku),SLE4(20018015525ku)125kuWG,200ku
本文标题:类风湿关节炎相关机制研究进展
链接地址:https://www.777doc.com/doc-4502189 .html