白癜风治疗进展

44JournalofPracticalDermatology,Feb.,Vol.No.1DOI10.11786/sypfbxzz.1674-1293.20150115100053E-mail:[e-mail]-mail:[e-mail][]2009(TNF)-α[][]R75841[]A[]1674-1293(2015)01-0044-04ThedevelopmentoftreatmentforvitiligoZHOUTian-tianZHANGHai-pingDepartmentofDermatology,XuanwuHospital,Beijing100053,China[Abstract]Vitiligoisonekindofskindiseasecharacterizedbydepigmentation,whichiseasytobediagnosedbutdifficulttobetreated.Forthegeneraltreatmentofthedisease,wecanrefertothenationalcommonviewforvitiligotreatmentof2009.Combinedtreatmenthasbecomethemostcommonlyusedmoderecentyears,forexample,phototherapycombinedwithtopicalapplications,surgerycombinedwithphototherapyandsoon.Newtreatments,suchastheimprovedsurgery,unconventionaloralmedicineandexternalapplications,genetherapyandbiologicalagents,arelessusedinclinicnowadays,theirefficacyneedtobefurtherproved.[Keywords]VitiligoCombinedtreatmentSurgeryNewtechniques[JPractDermatol,2015,8(1):44-47]D[1]2009[2]12009[2][3]1.1NB-UVBLotti[4]458NB-UVBNB-UVB90.2%96.9%[5]NB-UVB390.05%NB-UVBNB-UVB43.6%69.2%NB-UVB[6]NB-UVB160380NB-UVB40NB-45JournalofPracticalDermatology,Feb.,Vol.No.1UVB40NB-UVB81.58%55%NB-UVB75.68%Norda[7]NB-UVB400.1%27NB-UVB42.1%29%NB-UVB[8]NB-UVB1583A51B52NB-UVBC55NB-UVBC81.13%A56.00%B50.00%Gamil[9]NB-UVB20NB-UVBNB-UVB0.5mg/gNB-UVBYuksel[10]NB-UVBvitix30115NB-UVB215NB-UVBvitix1152176%100%51%75%2152114Akdeniz[11]453151NB-UVB2NB-UVB3NB-UVB13NB-UVBNB-UVBZhang[12]48NB-UVB45NB-UVB79.2%48.9%1.2308nm308nm[13]308nm137308nm308nm97.8%84.7%47.7%24.8%[14]308nm50ABA68.4%B41.8%AB16A75.4%B69.1%[15]308nm360308nm308nm56.4%36.1%27.5%35%83.9%70.1%[16]308nm0.03%73.80%308nm47.61%17.07%[17]308nm0.1%1803A57308nmB56C54308nmA75.43%B48.21%C14.81%NB-UVB308nm(PUVA)PUVANB-UVB308nmNB-UVB200PUVA150[18]1.382%91%3Majid[19]402NB-UVB11d83%90%90%50%75%75%100%46JournalofPracticalDermatology,Feb.,Vol.No.1Lee[20-22]1164d10dNB-UVB375%15213NB-UVB775%920mg/d22NB-UVB4890%22.1Krishnan[23]262PUVA90%2.2Li[24]110022720.6%56851.6%50%2.31/32/3Mohanty[25]FUE14975%11Singh[26]NCES3047124NCES223NCORSHFS4NCES83%90%100%NCORSHFS65%NCES92%75%NCORSHFS78%2.4[27]94.3%100%100%98.6%[28]-133.1E2PGE23Parsad[29]32293Noël[30]1Baktash[31]Kapoor[32]5640682275%33.2Manosroi[33-35](M5)B(16)F(10)M51.661.50B(16)F(10)6.814.37Manosroi[25]pAH7/TyrPTatTETPE47JournalofPracticalDermatology,Feb.,Vol.No.1PPETP7.675.076.298.465.366.58Manosroi3.3TNF-TNF-αAlghamdi[35]TNF-α622216TNF-α6[1]ColucciR,LottiT,MorettiS.Vitiligo:anupdateoncurrentpharmacotherapyandfuturedirections[J].ExpertOpinPharmacother,2012,13(13):1885-1899.[2].(2009)[J].,2009,42(9):591-592.[3],.[J].,2012,38(4):251-254.[4]LottiT,BuggianiG,TroianoM,etal.Targetedandcombinationtreatmentsforvitiligo.Comparativeevaluationofdifferentcurrentmodalitiesin458subjects[J].DermatolTher,2008,21(Suppl1):S20-S26.[5],.UVB[J].,2004,25(8):858.[6].80[J].,2013,34(1):96-97.[7]NordalEJ,GulengGE,RönnevigJR.Treatmentofvitiligowithnarrowband-UVB(TL01)combinedwithtacrolimusointment(0.1%)vs.placeboointment,arandomizedright/leftdouble-blindcomparativestudy[J].JEurAcadDermatolVenereol,2011,25(12):1440-1443.[8],,,.NB-UVB[J].,2009,23(4):1-3[9]GamilH,AttwaE,GhonemyS.NarrowbandultravioletBasmonotherapyandincombinationwithtopicalcalcipotriolinthetreatmentofgeneralizedvitiligo[J].ClinExpDermatol,201035(8):919-921.[10]YukselEP,AydinF,SenturkN,etal.ComparisonoftheefficacyofnarrowbandultravioletBandnarrowbandultravioletBplustopicalcatalase-superoxidedismutasetreatmentinvitiligopatients[J].EurJDermatol,2009,19(4):341-314.[11]AkdenizN,YavuzIH,GunesBilgiliS,etal.ComparisonofefficacyofnarrowbandUVBtherapieswithUVBalone,incombinationwithcalcipotriol,andwithbetamethasoneandcalcipotriolinvitiligo[J].JDermatologTreat,2014,25(3):196-199.[12]ZhangY,ChenCT,HuangS,etal.Efficacyobservationoffireneedlecombinedwithnarrowbandultraviolet-B(NB-UVB)forvitiligo[J].ZhongguoZhenJiu,2013,33(2):121-124.[13],,,.308nm[J].,2012,21(8):1358-1360.[14],,,.308nm[J].,2012,26(5):465-466.[15].308nm[J].,2013,6(2):102-104.[16],,,.308nm0.03%[J].,2012,6(6):343-345.[17],,,.308nm0.1%[J].,2012,21(9):1561-1564.[18]GawkrodgerDJ,OrmerodAD,ShawL,etal.Guidelineforthediagnosisandmanagementofvitiligo[J].BrJDermatol,2008,159(5):1051-1076.[19]MajidI,ImranS.Ultrathinsplit-thicknessskingraftingfollowedbynarrowbandUVBtherapyforstablevitiligo:aneffectiveandcosmeticallysatisfyingtreatmentoption[J].IndianJDermatolVenereolLeprol,2012,78(2):159-164.[20]LeeKJ,ChoiYL,KimJA,etal.Combinationtherapyofepidermalgraftandsystemiccorticosteroidforvitiligo[J].DermatolSurg,2007,33(8):1002-1003.[21]LeeDY,ChoiSC,LeeJH.Generalizedvitiligotreatedbycombinationtherapyofepidermalgraftandsystemiccorticosteroid[J].ClinExpDermatol,2009,34(7):838.[22]LeeDY,LeeKJ,ChoiSC,etal.Segmentalvitiligotreatedbythecombinationofepidermalgraftingandsystemiccorticosteroids[J].DermatolSurg,2010,36(4):575-576.[23]KrishnanA,KarS.Smashedskingraftingorsmashgrafting-anovelmethodofvitiligosurgery[J].IntJDermatol,2012,51(10):1242-1247.[24]LiJ1,FuWW,ZhengZZ,etal.Suctionblisterepidermalgraftingusingamodifiedsuctionmeth