壳聚糖支架在组织工程中的应用

:100129731(2002)0520459203X,,,,(,300072):,:;;:R318.08:A1,[1],3,,,,2,,,,,2,,,,[2](14)D2N2,N2(ECMs)(GAGs),,,,pH5,,GAGs(PECs)pH,PECs,pH,DNAGAGs,,,N2,2,;,;;,;,,ECMs,ECMsECMsGAGsGAGs,,,,,,;[35],,,,0.10.5MPa,3060kPa[6],P[7],22[8]33.1Lu[9],9542002,33(5)X:(G1999054305):2001209211,Matthew[6]24PECs,,Sechriest[10]2,,,,2pH,Chenite[11](GP),,pH,(CSPGP)CSPGP,3,,,,3.2,,,,BB(PDGF2BB)[12](2TCP),,,Zhang[13]2TCP2TCP,,2TCPLee[14]P2TCP,,28,(ALP)P2TCP,,,,,(BB(PDGF2BB)),Park[1517]PDGF2BBP2TCP2,,,,PDGF2BB,,,,PDGF2BB,,,,ALP[18]3.3,,2,,,,,,,Francois[19],,,,Vaissiere[20],22(CS2GAG2Col)(DPPA2Col),,,55%,45%,CS2GAG2ColDPPA2Col;,,CS2GAG2Col,DPPA2Col,,CS2GAG2Col,CS2GAG2ColDPPA2Col,,,,;,,,,[21,22]Mi[23],,,,2,,2170%,,35,3.4,Elcin[24],,PP,0642002,33(5)P,,,2,,[25,26]P,,,Elcin[27],,,4,,,,,,DNAN2DNA,DNA,DNA,[28],,,,:[1]LangerR,VacantiJP.[J].Science,1993,260:9202926.[2],,.[J].,2000,14(10):8210.[3]MadihallyS,MatthewH.[J].Biomaterials,1999,20:111321142.[4]CarenCL,BerndWM.[J].InternationalJournalofPharmaceutics,2000,194:2292237.[5]SeongH,BackHT.[J].PolymerPreprints,2000,41:168721688.[6]FrancisSuhJK,MatrhewH.[J].Biomaterials,2000,21:258922598.[7]ShenF,CuiYL,YaoKD.[J].PolymerInternational,2000,49:159621599.[8]MaoJS,WangXH,YaoKD.[J].ChineseJournalofBiomedicalEngi2neering,2001,10(2):66269.[9]LuJX,ProdhommeauxF,MeunierA,etal.[J].Biomaterials,1999,20:193721944.[10]SechriestFV,MiaoYJ.[J].JournalofBiomedicalMaterialResearch,2000,49:5342541.[11]ChieniteA,ChaputC,WangD,etal.[J].Biomaterials,2000,21:215522161.[12]BurgK,PorterS,KellanJ.[J].Biomaterils,2000,21:234722359.[13]ZhangY,ZhangMQ.[J].JournalofNon2CrystallineSolids,2001,282:1592164.[14]LeeYM,ParkYJ.[J].JournalofPeriodontal,2000,71:4102417.[15]ParkYJ,LeeYM.[J].Biomaterials,2000,21:1532159.[16]LeeYM,ParkYJ.[J].JournalofPeriodontal,2000,71:4182424.[17]ParkYJ,LeeYM.[J].JournalofControlledRelease,2000,67:3852394.[18]CaiKY,LinSB,YaoKD.[J].JournalofBiomedicalMaterialRe2search,inpress.[19]FrancoisB,DanyH.[J].Biomaterials,1993,14:7492754.[20]VaissiereG,ChevallayB.[J].Medical&BiologicalEngineering&Computing,2000,38:2052210.[21]LokeWK,LauSK.[J].JournalofBiomedicalMaterialResearch,2000,53:8217.[22]MaJB,WangHJ.[J].Biomaterials,2001,22:3312336.[23]MiFL,ShyuSS.[J].Biomaterials,2001,22:1652173.[24]ElcinAE,ElcinYM.[J].NeurologyResearch,1998,20:6482654.[25]KawaseM,MichibayashiN.[J].BiologicalPharmaceuticsBulletin,1997,20:7082710.[26]YagiK,MichibayashiN.[J].BiologicalPharmaceuticsBulletin,1997,20:129021294.[27]ElcinYM,DixitV.[J].ArtificialOrgans,1999,23:1462152.[28]LiuWG,YaoKD,LiuQG.[J].JournalofAppliedPolymerScience,inpress.:(1978-),,,,,TheapplicationsofchitosanscaffoldsfortissueengineeringYEFen,YINYu2ji,SUNGuang2jie,SONGXue2feng,YAOKang2de(ResearchInstituteofPolymericMaterials,TianjinUniversity,Tianjin300072,China)Abstract:Theadvancesintheresearchesandapplicationsofchitosanbasedscaffoldsfortissueengineeringincludingcartilage,bone,skinetc.arereviewed.Resultsprovedthatchitosanisapromisingbiomaterialsfortissueengineering.Keywords:chitosan;tissueengineering;three2dimensionalscaffolds1642002,33(5)