乳腺癌前哨淋巴结超声造影的研究进展

··DOI10.3877/cm[e-mail]。sentinellymphnodeSLN。SLN。SLN2090。、、、、SLN1。SLN。1“”2。2SLNSonoVue。SLN。BraccoSF62.5μmSF62～10μl/ml5×108/ml3。、、、15min。Rubaltelli4SonoVue·614·2012864ChinJBreastDisElectronicEditionAugust2012Vol.6No.4。。、、80%、76%78%SonoVue92%、93%93%。SLNSonazoid。200712.4～3.4μm。、5。10～15min、。。SonazoidSLN。Goldberg6、、、SonazoidSonazoid、SonazoidSLNSLN。。。L-7。、。。。3SLN3、·714·2012864ChinJBreastDisElectronicEditionAugust2012Vol.6No.4。mechanicalindexMI。MI0.1～0.2、。SLN8-9coherentcontrastimageCCI。10。、。。4SLNSLN、、、。。SLN11。。12。1387%93%89%。5SLN5.1、、、、。L/T＞2L/T＜2。314123。·814·2012864ChinJBreastDisElectronicEditionAugust2012Vol.6No.4。31511/221/23。。16。5.2colorDopplerflowimagingCDFIpowerDopplerflowimagingPDI。CDFI。PDI。Tschammler17、、。318123。19。5.3SLNSLN。133123。。。QontraXtROIAT、TTP、PI、β-20。21。。、·914·2012864ChinJBreastDisElectronicEditionAugust2012Vol.6No.4、22。23DFY-ⅡGS、dB、。。6SLN。。SLNSLN1SLN234SLN。。【】【】R445.1【】A1YuYLiuJBYinLX．ApplicationprogressoflymphographyinoncologyJ．FrontMedChin20093113-19．2．M．201030-32．3DindyalSKyriakidesC．UltrasoundmicrobubblecontrastandcurrentclinicalapplicationsJ．RecentPatCardiovascDrugDiscov20116127-41．4RubaltelliLKhadiviYTregnaghiAetal．Evaluationoflymphnodeperfusionusingcontinuousmodeharmonicultrasonographywithasecond-generationcontrastagentJ．JUltrasoundMed2004236829-836．5KudoM．Sonazoid-enhancedultrasoundinthediagnosisandtreatmentofhepatictumorsJ．JMedUltrasound2008162130-139．6GoldbergBB．ContrastenhancedsonographicimagingoflymphaticchannelsandsentinellymphnodesJ．UltrasoundMed2005247953-965．7HauffPReinhardtMBrielAetal．MoleculartargetingoflymphnodeswithL-selectionligand-specificUScontrastagentafeasibilitystudyinmiceanddogsJ．Radiology20042313667-673．8VerbeekXALedouxLAWilligesJMeta1．ExperimentalinvestigationofthepulseinversiontechniqueforimagingultrasoundcontrastagentsJ．JAcoustSocAm20001074228-229．9KimAYChoiBIKimTKeta1．Comparisonofcontrast—enhancedfundamentalimagingsecondharmonicimagingandpulse—inversionharmonicimagingJ．InvestRadiol20013610582-588．·024·2012864ChinJBreastDisElectronicEditionAugust2012Vol.6No.410D’OnofrioMFaccioliNMalagòRetal．Standardizeandcomparecontrast-enhancedultrasonographicdigitalimagesobtainedwithdifferenttechnologieshowtoovercomethesubjectivityJ．JDigitImaging2007203256-262．11SeverABroilletASchneiderMetal．Dynamicvisualizationoflymphaticchannelsandsentinellymphnodesusingintradermalmicrobubblesandcontrast-enhancedultrasoundinaswinemodelandpatientswithbreastcancerJ．JUltrasoundMed201029121699-1704．12KlimbergVSRubioITHenryR．SubareolarversusperitumoralinjectionforlocationofthesentinellymphnodeJ．AnnSurg19992296860-864．13．J．20061511849-852．14AyataZApaydinMVarerMetal．DifferentialdiagnosisincervicallymphadenopathiesefficacyofB-modecolorandpowerDopplerultrasonographyJ．KulakBurunBogazIhtisDerg2009194173-178．15BediDGKrishnamurthyRKrishnamurthyS．CorticalmorphologicfeaturesofaxillarylymphnodesasapredictorofmetastasisinbreastcancerinvitrosonographicstudyJ．AJRAmJRoentgenol20081913646-652．16WangYBZhangHGaoWetal．EvaluationoftheultrasonographicfeaturesofaxillarylymphnodemetastasisinbreastcancerJ．ChinJOncol200628165-69．17TscharmmlerAGunzerUReinhartEelal．Thediagnosticassmentofenlargedlymphnodesbythequalitativeandsemiquantitataiveevaluationoflymphnodeperfusionwithcolor-codedduplexsonographyJ．Rofo19911544414-418．18AhujaATYingM．EvaluationofcervicallymphnodevascularityacomparisonofcolourDopplerpowerDopplerand3-DpowerDopplersonographyJ．UltrasoundMedBiol200430121557-1564．19NymanHTKristensenATSkovgaardIMetal．Characterizationofnormalandabnormalcaninesuperficiallymphnodesusinggray-scaleB-modecolorflowmappingpowerandspectralDopplerultrasonographyamultivariatestudyJ．VetRadiolUltrasound2005465404-410．20YuMLiuQSongHP．Clinicalapplicationofcontrast-enhancedultrasonographyindiagnosisofsuperficiallymphadenopathyJ．JUltrasoundMed2010295735-740．21ZhaoHXuROuyangQetal．Contrast-enhancedultrasoundishelpfulinthedifferentiationofmalignantandbenignbreastlesionsJ．EurJRadiol2010732288-893．22ZenkJBozzatoAHornungJetal．NecklymphnodespredictionbyComputer-assistedcontrastmediumanalysisJ．UltrasoundMedBiol2007332246-253．23．DFY-ⅡJ．200575338-340．2011-04-11．J/CD．201264416-421．·124·2012864ChinJBreastDisElectronicEditionAugust2012Vol.6No.4