恶性淋巴瘤患者血清乳酸脱氢酶β-2-微球蛋白测定的临床意义

22(230022)[]2246,22t+LDH(P0.05),22MGLDH(P0.05),22MG,LDH22MG,(P0.05)22[];;22[]R733.1[]B[]1005-8664(2001)02-49-02Clinicalsignificanceofserumlacticdehydrogenaseand22microglobulininmalignantlymphomaHAOJi2qingTheFirstAffiliatedHospitalofAnhuiMedicalUniversity,Hefei230022[Abstract]ObjectiveTodiscusstheclinicalsignificanceofserumlacticdehydrogenaseand22microglobulininmalig2nantlymphoma.MethodsSerumlacticdehydrogenaseand22microglobulinin46patientswithmalignantlymphomawerede2terminedbyspeed2ratiomethodandradioimmunoassaytechniqueandwerestatiscallyanalysed.ResultsComparingwith+stagelymphomapatients,theserumLDHleveloforstagepatientshadnosignificantdifference(P0.05),onthecon2trarytheserum22MGlevelhadsignificantdifference.TheserumLDHlevelhadsignificancedifferencebetweenhighgradeandintermediategradegrouporlowgradegroup(P0.05),andtheserum22MGlevelhadnosignificantdifferencebetweenthem.TheserumLDHand22MGlevelweresignificantlyincreasedinadvancedpatientsanddecreasedinpatientsresponsingtochemotherapy.ConclusionsItwassuggestedthatthelevelofserumLDHand22MGmaybeconsideredasareferencetocor2relatewiththephaseandhistologicaltypeofthedisease,andtoestimatethetherapeuticeffectandprognosis.[Keywords]malignantlymphoma;serumlacticdehydrogenase;serum22microglobulin(ML),,,22:1996119991246,(HD)19,(NHL)2732,1487637:2000-04-10:(1969-),,,,,:22RIA,,LDH80225u/L,22MG1.6150.335mg/L1966Rye,19821971AnnArbor[1]37COPPCHOPWHO[2]()()94200182©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(P0.05),22MG2LDH(P0.05),22MG3,LDH22MG4,LDH22MG(P0.01)1LDH22MGnLDH(u/L)22MG(mg/L)+13216.89101.973.960.5912276.58111.324.490.6721303.17154.545.170.99P0.050.05:+2LDH22MGnLDH(u/L)22MG(mg/L)11498.95197.185.391.1720357.01158.244.660.7615265.84143.895.411.58P0.050.05:3LDH22MGnLDH(u/L)22MG(mg/L)37317.43121.383.041.199210.5590.791.980.57P0.050.054LDH22MGnLDH(u/L)22MG(mg/L)24229.91100.342.360.8413360.76151.465.492.67P0.010.01,,1992Shipp(AnnArborLDH,IPI),LDH,LDHAnnArbor[3]LDH[4],,,LDHIPI,22[1]22MG,,,22MGSwanLDH22MG,24100%54%19%,CR93%69%44%CR,22MG[5]22MG,,[6]+LDH(P0.05),22MGLDH(P0.05),22MG,LDH22MGLDHAnnArbor,22MG,,LDH22MG,,LDH22MG[1],,.[M].:,1997:48-54,105-112,133.[2].[M].:,1999:33-35.[3],.LDH[J].,1999;18(2):216-217.[4].[M].:,1997:126-127.[5],.[J]..,1996;19(1):53.[6],,.22[J]..,1990;11(2):20-23.05200182©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.