单克隆抗体技术历史与发展简述

陈　光(100037)1(monoclonalantibody,shortforMcAb)(),,1975KohlerMilstein,,1984,,,(polyclonalantilymphocyteantibody),,,,T,,B,,,,(antilympho-cyteserum,ALS);(antitymphocyteserum,ATS)ALSATS(antilymphocyteglobulin,ALG)(antithymocyteglobulin,ATG),,,B;,KohlerMilstein:(B),,,,,(2002,66)23:1)B,,,,B,B2)B,();,,,3)HAT(H-A-T-)DNAGln()DNA;HGPRT()TK()DNAHAT,DNABHGPRTTK,HATBB,HGPRTTK,HAT2,33.13.1.11),,,,,2),2436h,(LH)58200338924hLH,3),,10%,,4),,,,,300ng/mL,3.1.2A,,,[131I]-,,,()120003.1.3,HIV:l);2)HIV;3)HIV;4)HIV:5):HIVHIV,HIV,33,3.1.4,:CD3I;;;,;clenoliximab;3.2,,,,,:,,,,,,,,,,,,,,,,4,2002101415::1);2);3):;4),,,;5):;6),,,592003389(1)郭晓强(050081)　从拉斯克奖的获奖者来简要看一下20世纪下半个世纪以来生命科学的发展趋势,一方面对拉斯克奖有一了解,另一方面对生命科学的历史及现在的热点有一大致了解。　拉斯克奖　生命科学(,LaskerMedi-calResearchAwards)(1946),200247,3:(1997),56,,20(,),DNA(1947)DNA(1960)(1968)(1981)(1988)(1980),(1952)(1959)(1962)(1977)(1984)(1987)TMHC(1995),,,,,196250%(),66(,90%),,1995,MHC(1995)(1997)(1999)(2000)(2002),1995,2002197119462002,()()()(),,,,,,,,,,,Ig,,,,,,,,,:,,!1,,..:,2002.2..:,2002.(BH)602003389