新型疫苗佐剂的研究进展

©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(8):10153(400038),,,,,,,DNA,:2005201220:20052052083:[e-mail](),,,,,,,1,()()T(CTL)[1],,,,,,1.1,,//MF59AS02Montani2deISA251ISA2720,MF59Chiron,Tween80Span85[2]AS02A(MPL)(QS221),Th1CTL,MPLQS221[3]MontanideISA251ISA2720,MontanideISA251,MontanideISA2720,[4],(virosome)©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(8):(PLG)(immuneresponse2stimulatingcomplexes,ISCOMs)DC2Chol,150nm[5]PLG,,,DNAISCOMs,40nm,,[6]DC2Chol,,[7],CpG(CpG2ODN),A(MPL)OM2174(LT)DNA,CpG,(ODN),CpG2ODN[8]MPLOM2174,,6;A,3,,,45[9]LT,,,,,LT,[10]1.2,,,,,,,/,MF59QS21AS02Montanide,,,Th1(IFN2IL22)CTL,,,IL22IL212GM2CSF,,,/,,LTLT,,sIgA,,,,,,,,,,,,,,,,2,(),;,,2.1,,Dubovsky:,DuffyPvR,PvR[11],ISA720,Dubovsky(ICC21132),11©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[12]Stewart(RTS.S)AS01AS022,AS01AS02Th2,AS01CD8+,IFN2,[13],AS05AS08ISA720GM2CSFIL24MSP1242MSP1219PfCP22Pk2CSP;MF59ISA51PcMSP1P19;PLGQS21MF59LSA32729LSA32NNMSP12422.2,,Weiss,,,(CSPSSP2AMA21MSP21.42)DNA;CS,,,,MSP21.p19(QS21AS02MF59ISA51)(M.sinica),(P.cynomolgi),,ISA51,MSP21(MSP21.42),QS221ISA251,IFN2IL24,,,,2.3HIV,SrivastavaHIV2env,envMF59,,,,[14]Mwenda,,,,ISCOMs,,,IL212,,SkeikyAS02(Guineapig),,,MPL2SE,,MPL,MPL.RC2529,3,,,(QS221AS02ISA251)(IL212DC)(LT);(PLGISCOMsDC2chol)(OM2174CpG2ODN),MPL3.13.1.1MontanideISAMontanideISA,ISA51ISA720,4000HIV,,ISA720,[15]21©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(8):,MontanideISA720CS,MontanideISA720,,100gMontanideISA720,300g,2100g1,MontanideISA720,100%()[16]MSP1MSP2MontanideISA720,85%,11%[17]3.1.2DC2CholDC2Chol,DC2Chol,(H.pylori)HIV,H.pylori,HIVtatHIV,DC2Chol,H.pylori,,DC2Chol,DC2Chol,,3.1.32MPLL2,,Th1IgGL2,MPLTh1,L2MPL,,L22MPL,,L22MPL[18,19]3.1.4CpG2ODNCpG2ODN,,Th1,CpG,,CpG2ODNI,CpG,CpGCpGTLR29,,CpG2ODN[20]3.1.5AS02AS02MPLQS221,,Th1CTLHIV/,RTS.SAS02111,[3],,(),,[21],AS02b3.23.2.119451960,1960,,,ISA720ISA51,,,,,,3.2.2,,,????I,31©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.:MF59B(rCTB)AS04MF59Chiron,,,T,MF59(),,37,,()20044,SBLVaccinABDukoral,rCTB,,85%,620051,(rBS2WC),rCTB,,85%,70%,3,86%,(rBS2WC)220052AS04FendrixAS04,,,5,,,:;;,,,[1]MarcianiDJ.Vaccineadjuvant:roleandmechanismsofactioninvaccineimmuogenicty.Drug2Discov2Today,2003,8(20):934943[2]PoddaA,Del2GiudiceG.MF592adjuvantedvaccines:increasedimmunogenicitywithanoptimalsafetyprofile.ExpertRevVaccines,2003,2(2):197203[3]GarconN,HeppnerDG,CohenJ.DevelopmentofRTS,S/AS02:apurifiedsubunit2basedmalariavaccinecandidateformulatedwithanoveladjuvant.ExpertRevVaccines,2003,2(2):231238[4]AucouturierJ,DupuisL,DevilleS,etal.MontanideISA720and51:anewgenerationofwaterinoilemulsionsasadjuvantsforhumanvaccines.ExpertRevVaccines,2002,1(1):111118[5]BungenerL,IdemaJ,Ter2VeerW,etal.Virosomesinvaccinedevelopment:inductionofcytotoxicTlymphocyteactivitywithvirosome2encapsulatedproteinantigens.JLiposomeRes,2002,12(122):155163[6]KerstenGF,CrommelinDJ.LiposomesandISCOMs.Vaccine,2003,21(9210):915920[7]GuyB,PascalN,FranconA,etal.Design,characterizationandpreclinicalefficacyofacationiclipidadjuvantforinfluenzasplitvaccine.Vaccine,2001,19(13214):17941805[8],,,1CpG1,2002,82(8):553556XuHL,WangSHF,GuoF,etal.NatlMedJChina,2002,82(8):553556[9]PajakB,GarzeV,DaviesG,etal.TheadjuvantOM2174inducesboththemigrationandmaturationofmurinedendriticcellsinvivo.Vaccine,2003,21(9210):836842[10]LemereCA,SpoonerET,LeveroneJF,etal.IntranasalimmunotherapyforthetreatmentofAlzheimersdisease:41©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(8):EscherichiacoliLTandLT(R192G)asmucosaladjuvants.Neurobiol2Aging,2002,23(6):9911000[11]SinghAP,PuriSK,ChitnisCE.Antibodiesraisedagainstreceptor2bindingdomainofPlasmodiumknowlesiDuffybindingproteininhibiterythrocyteinvasion.MolBiochemParasitol,2002,121(1):2131[12]DubovskyF,MoreeM,RabinovichR.Malariavaccines:orphansintransition.DevBiol(Basel),2002,110:4753[13]EngersH,KienyMP,MalhotraP,etal.Meetingreport:thirdmeetingonnoveladjuvantscurrentlyinorclosetoclinicaltesting.Vaccine,2003,21:35033524[14]SinghM,SrivastavaI.Advancesinvaccineadjuvantsforinfectiousdiseases.CurrHIVRes,2003,1(3):309320[15]ToledoH,BalyA,CastroO,etal.AphaseIclinicaltrialofamulti2epitopepolypeptideTAB9combinedwithMontanideISA720adjuvantinnon2HIV21infectedhumanvolunteers.Vaccine,2001,19(30):43284336[16]LawrenceG,ChengQQ,ReedC,etal.Effectofvaccinationwith3recombinantasexual2stagemalariaantigensoninitialgrowthratesofPlasmodiumfalciparuminnon2immunevolunteers.Vaccine,2000,18(18):19251931[17]GentonB,Al2YamanF,BetuelaI,etal.Safetyandimmunogenicityofathree2componentblood2stagemalariavaccine(MSP1,MSP2,RESA)againstPlasmodiumfalciparuminPapuaNewGuineanchildren.Vaccine,2003,22(1):3041[18]DrachenbergKJ,HeinzkillM