孙秀发教授论：酒精与糖尿病的关系

POBox2345Bejiing100023,ChinaFax:[phone]Emial:[e-mail]~w·wjgn.etcomWOrldChinJDigestol2005Februaryl:13(3):290293ISSN10093079CN141260lR2005。C0MMEN’UJ“..430030,.1945。4,,、.、,,,,、`.、’“.“p.、“.、.“’、“’、“’.,.:},43003013,、sunxiufhaoo·com:02783653307:02783653307:20041230:2005011270,,,,,.,,.,、.:;..20053(3):290293(2002),、、.,“”,,、..,..,[’」.,,、、LZJ.,.、、,.11.1,.,ld1298%[5].`OJ.(“,’),,〔“,.,,L’3`5〕.:“U”.1.2`,U”`,J”(、,).,2..weieta,1Q(161.89/wk,5/wk),QZ(61.9122.79/wk,510/wk),Q3(122.8-276.69/wk,1022/wk)Q4()276.69/wk,22/wk).,QZ,Q3、Q4QZ2.22.4,QlQZ1.81.4.U、、、BM、、、、HDL、[’6J.,”`”〕,BMILZ。,“」.,,,23[」.,UJ.,,..29122.1,.、,NADH/NA+D.、,NADH(),NADH/NAD`,H+[241.NADH/NAD`tp,.NADH/NA+D/.489,45%[2“1.,,,.,12%,,,.,L26]..,,23h[,7〕.p.,,sz[291`〔3“」.,,,.C,〔3’32j.2.2、2.2.1.50%,(p),,,,.Kok。、p、、p,p、〔’3〕.2.2.2、.、pL.、,,:35[37〕.p,〔36].,,(0,50,100,200,400nlnIolL/)NIT1(p)6,12,24h,NIT1、,(6h),(12,24h);,,.,t:`”〕,〔3””},p(HITT15),30%,4[`〕.、.2.2.3:(1),(G)K(HK)、(PFK)(P)K,PFK.GKHK,p.,GK,.GKPFK,L`2」,NT1GKmRNA.,,,(2),(eraCtiVeoxy-genSpecieS,ROS)ROS,(oxidativestress)..,50%(TSO)D,NO、(MD)A36[」.,,p.,24h,,NT-1MDA,SOD、GSHPx,GSH292ISSN10093709CN142160/R200521313,Caspase3,,,Caspase3.NT1,,.、Caspases〔`3」,Caspase3caspase,aCspase3,caspase345[J.NH1CaspaseS,Caspase3NITl,CasaPse3.,,,.(3):,46[47].TNFa、ILlpL-6〔37〕.,、p,..2.3p,,,,(RS),,SHZSH3,3(PI3kinase),,../,.;1(ISR1),,DNA、(PCN)A3(GAPD)H,(MAP)K48[50].RSmNRA,J,LS’.,,.,、、、、,.、.,,.:,、、;,,.U,.,,.,.、.2000;4:5659LuehsingerJA,TangMX,SiddiquiM,hSeaS,MayeuxR.AI-eoholtakeandriskofdemenita.JAGeriatrSoe2004;52:540546..2003;11:689,,,.53.2003;12:746747MayerNeWan.BQesenbenyCPJr,irFemanGD,eSlbyW.Alcoho!eosnumPitonandinsuilneocnentraitosn.Rofeofinsluininassodaitosnofalehoolintakewihtihhgdensiyt11-PoPorteincholesetrolanditrglyeeridse.Cicrula1001993;88:21902197RazayG,HeatonKW.iAeoholeonsumPitonandeardiovas-eularriskfactosrinddleagedmen.aCiO”aseRiskaFctosr19955:200205hi5,WmeitJ,POeweW,EggerG,OberhollenzerF,Mugg〕M,BonoraE.InsulinsensitivityandregularalcoholconsumPiton:large,ProsPecitve,erossseetionalPoPulaitonstUdy(Bruneekstudy).BrMed11996;323:10401044KonratC,MennenLl,CaeesE,LePinayp,RakotozafyF,FohtanA,BalkauB;D.E.5.1.R.StUdyGrouP.Aleoholinatkeandafs9insulininFrenchmenand~en.hTeD.E.5.1.R.Study.DiabetesMeatb2002;28:116123FlanaganDE,MooreVM,GodslandIF,CoekingtonRA,RobinsonJS,hPilliPsDl.AlcoholeonsumPtionandinsulinresistanceinyoungadulis.EurJClinlnest2000;50:297302DaviesMJ,BaerDJ,Judd,BrownED,CamPbellws,Tay-lorPR.EffeetsofmoderatealeoholintakeonfastinginsulinandglueoseconcentraitonsandinsulinsensiitviytinPost-menoPausalwomen:arandomizedeontrolledtrial.IAM2002;287:25592562FaeehiF,ChenYDI,eRavenGM.Lihgtotmoderaetaleoholintake15associaetdwihtehnaneedinsulinsensiitviyt.Diabe-tesCae199417:115119GoudeD,FagebrergB,HultheJ·AleoholeonsumPtion,themeatboilesyndromeandinsulinersistaneein58earldeilin-eallyhealthymen(AIRstUdy).Cli”Sci2002;102:345352.29313RazaGy,HeatonKW.AleoholeonsumPtionandeardiovas-cularriskfaetorsinmiddleagedmen.aCrd。scRisketors321995;5:20020514LazarusR,sParrowD,WeissST.Alcoholintakeandinsu-linlevels·ThenormaitveaigngstUdy.AJEidemiol1997;145:90991615416j3àBellRA,MayerDavisEJ,MaritnMA,D’AgosintoRB,HaflnerSM.AssodiatonsbeheenalcoholconsumPitonandinsulinsen-isitviytandcaridvoasCtJlaridseaseisrkfacot:nsIulResistanceandAtheroselerosisSutdy.DtesCaer2000;23:1。16WeiM,GibbonsLW,tchellLT,KamPertJB,BlairsN.Aleo-holintakeandinddeneeofytPe2diabeetsinmen.DabetesCe2000:23:1822331617183719deVegtF,DekkerJM,GroeneveldWJ,NijPelsG,StehouwerCD,BouterLM,HeineRJ.ModeratealeoholeonsumPiton15assoicatediwhtlowerirskforincidentidabeetsandmoratliyt:theHoonrStUdy.DiabetesReshCiniParct2002;57:5360HolbrookTL,BarrettonnorE,Wingardl)L.AProsPectivePoPulationbaseds-tUdyofaleoholandnoninsulindePen-dentdiabetesmelliuts.AmJEPidemiol1990;132:902909BalkauB,RandrianjohanyA,paPozL,EsehwegeE.Re:`’AProsPeeitvePoPulaitonasedstudyofaleoholuseandnon-insuldePendentdiabetesmellitus”.AJEPidemiol1991;134:1469147038904320sTumuraK,HayashiT,Suematsuc,EndoG,FujiiS,okadaK.DailyaleoholeonsumPitonandhteriskoftyPe2diabetesinJaPanesemen:hteOsakaHealhtSuvrey.DiahetaCre1999;22:14321437Cli”EndoerinolMetab2002;87:12331238ChrisitansenC,ThomsenC,Rasmusseno,HauerslevC,BalleM,HansenC,HermansenK.Effeetofaleoholonglueose,insulin,freefattyLaeidanditracylglycerolresPonsestoalightmealinnoninsulindePendentdiabeitesubjeets.BrJNutr1994;71:449454KokoV,TodorvoieV,NikoileJA,GlisieR,CaikeM,LaekovieV,petroinjevieL,StojkovieM,VaraigeJ,JaincB.RatPancre-aiteBeellsafterehrocrualeoholfeeding.Amohomeitreandifnestrueturalstudy.HistolHistoPathol1995;10:325337.p.2001;21:225227,,..2002;31:8890,,,,,,,.2004;33:440443,,,,,,,..2004;20:11741175TiengoA,ValerioA,MolinariM,MeneghelA,LaPollaA.Effeetofethanol,aeetaldehydeandaeetateoninsulinandglueagonsseeretioninthePerfusedratPanereas.Diabetes198130:705709WalshCH,O`SullivanDJ,Corkl,Effeetofmoderatealeoholintakeoneontrolofdiabetes.Dbetes197423:440442HolleyDc,BagbyGJ,CurryDL.Ethanolinsulininterrela-itonsihPsinhteratstUdiesinvitroandinvivo:eviden